VUMC Main Calendar Events

  • 1/24/2018
    12:15 pm - 1:15 pm
    VICB Seminar, Nick Skelton, Genentech, 'Small Molecule Lead Discovery and Optimization at Genentech'

    The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Nick Skelton, Genentech: "Small Molecule Lead Discovery and Optimization at Genentech"

      

    Key Lecture Points
    · Multiple approaches and technologies are needed to successfully identify lead compounds for drug discovery
    · HTS screening and structure-guided optimization to generate potent and selective inhibition of the kinase AKT (an important oncology target)
    · Fragment-based approaches to expand chemical matter for inhibition of NAMPT (a cancer metabolism target)
    · Peptide phage-display used to identify ligands for a cryptic binding site on PCSK9 (a target for treating high cholesterol)

    Contact: Michelle Armstrong


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