The Vanderbilt Institute of Chemical Biology presents Dr. David Cortez, Vanderbilt University, "Genome Maintenance by the DNA Damage Response"
We are interested in how a cell maintains its genome. This simple basic science question has very important implications for human health. Defects in genome maintenance cause cancer and many other diseases including neurodegenerative disorders and premature aging.
Genome maintenance includes many cellular activities. Replicating DNA, detoxifying environmental mutagens, properly building a mitotic spindle to segregate replicated chromosomes, and repairing damaged DNA are only a few of the activities required for genome maintenance. We have focused our attention on the regulation of these diverse biological activities in particular when cells are challenged with DNA damage. Collectively this regulation is called the DNA damage response.
We use a multidisciplinary approach to this research including biochemistry, genetics, cell biology, and structural biology in both mammalian and yeast systems.
Contact: Stephen Doster