Epithelial Biology Center Faculty Candidate Seminar.
David Bryant, Associate Researcher, Department of Anatomy, University of California, San Francisco
Talk title: "Should I stay or should I go? Cracking the molecular code for epithelial
tissue organization and polarity."
Abstract: The formation of glandular epithelial tissues requires the collective co-ordination
of apical-basal polarization of neighboring cells around a common, central lumen.
Though we known the identity of many molecules involved in apical-basal polarity
formation, how this polarity is coordinated between neighboring cells and
oriented in the correct configuration is largely unknown. Using 3-Dimensional
(3D) cyst culture of kidney epithelial cells, we have begun to unravel the
membrane trafficking, apical polarity, and signaling processes that cells
collectively use to generate complex multicellular structures. Notably, we have
recently discovered a molecular switch, dependent on integrin, RhoA and PKC
signaling, that regulates whether epithelial cells organize their apical polarity
around a lumen, or develop collective cell migration and invasive behaviors. I will
discuss our understanding of the molecular mechanisms that underpin
multicellular epithelial tissue organization.
Contact: Meghan O'Loughlin