MLPCN Project Assignments
Chemistry Fast Track • Extended Characterization • Probe Projects
Chemistry Fast Track
Assay Provider |
Screening Center |
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Discovery of Novel Allosteric Modulators of the D2 Dopamine Receptor (Grant #NS064831-01) |
University of New Mexico |
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Optimization of novel mGluR5 negative allosteric modulators that do not interact with the same site as MPEP and related mGluR5 NAMs (Grant # R01 MH062646) VU Chemistry Team Leader: Kyle Emmitte |
Jeff Conn and Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery |
N/A |
Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy (Grant # R01 MH062646) VU Chemistry Team Leader: Shaun Stauffer |
Jeff Conn and Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery |
N/A |
Optimization of novel mGluR3-selective allosteric modulators (Grant # R01 NS031373) VU Chemistry Team Leader: Craig Lindsley |
Jeff Conn and Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery |
N/A |
Developing isoenzyme selective inhibitors of phospholipase D as an antiviral VU Chemistry Team Leader: Craig Lindsley |
Vanderbilt University Medical Center |
N/A |
Developing potent and selective CK2 inhibitors as translational tool forfuture regenerative medicine (Grant # 5U01HL100398-02) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University Medical Center |
N/A |
Developing potent and selective beta-catenin inhibitors as translational tool for future regenerative medicine (Grant # 5U01HL100398-02) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University Medical Center |
N/A |
Developing potent and selective BMP inhibitors as translational tool for future regenerative medicine (Grant # 5U01HL100398-02 ) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University Medical Center |
N/A |
Identification of Novel Modulators of GIRK Channel Activity (Grant # 1R21NS057041-01) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University Medical Center |
N/A |
Small molecule inhibitors of fluorogen-FAP tag interactions: case study of non-fluorescent analogs of thiazole orange (Grant # 1R03 DA031668-01) VU Chemistry Team Leader: Shaun Stauffer |
Carnegie Mellon University |
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Optimization and Mechanistic Characterization of Small Molecules that Restore E-cadherin Expression (Grant # 5P50 CA95103-09) VU Chemistry Team Leader: Craig Lindsley |
Vanderbilt University Medical Center |
N/A |
Probe Development for Protease Activated Receptor-4 (Grant # 5P50 HL081009-03) VU Chemistry Team Leader: Mike Wood |
Vanderbilt University Medical Center |
N/A |
Probe Development for FATP2-mediated Fatty Acid Uptake Inhibition (Grant # 2 R01 DK071076) VU Chemistry Team Leader: Shaun Stauffer |
University of Nebraska |
N/A |
Extended Characterization
Assay Provider |
Screening Center |
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Chemical optimization of in vitro pharmacology and DMPK properties of the first highly selective mAChR 5 (M5) Positive Allosteric Modulator (PAM) (Grant # X01 MH077607-1) |
Jeff Conn and Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery
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N/A
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Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (Grant # X01 MH077607-1) VU Chemistry Team Leader: Corey Hopkins |
Jeff Conn and Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery |
N/A |
Structure-Activity Relationship (SAR) and Chemical Optimization of Advanced mGlu4 Lead Candidates as a Potentially New Treatment Option for Parkinson’s Disease (Grant # NS053536-01) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt Center for Neuroscience Drug Discovery |
N/A |
DMPK and in vivo Studies of the First Sub-Micromolar Disruptor of the Menin- |
University of Michigan |
N/A |
DMPK and in vivo Studies of the Highly Selective Non-Covalent SARS main |
Purdue University |
N/A |
Extended Characterization of a Novel Chemical Inhibitor of TRPC4 Channels (Grant # NS056942-01) VU Chemistry Team Leader: Corey Hopkins |
University of Texas Medical School at Houston |
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An Enhanced Small Molecule Inhibitor of the KCNQ2 (Kv7.2) Channel (Grant # 1 R03 DA027716-01) VU Chemistry Team Leader: Corey Hopkins |
John Hopkins Ion Channel Center |
Probe Projects
Assay Provider |
Screening Center |
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Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen (Grant # MH077606-01) |
P. Jeffrey Conn/Colleen Niswender Vanderbilt Center for Neuroscience Drug Discovery |
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Discovery of Novel Allosteric Agonists of the M4 Muscarinic Receptor: Primary Screen (Grant # MH077607-01) |
Vanderbilt Center for Neuroscience Drug Discovery |
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Discovery of Novel Allosteric Agonists of the M5 Muscarinic Receptor: Primary Screen (Grant # MH077607-01) |
Vanderbilt Center for Neuroscience Drug Discovery |
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A direct assay for HTS of Gi/Go-linked GPCRs: mGluR8 as the prototype (Grant # NS053536-01) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt Center for Neuroscience Drug Discovery |
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Small Molecule Modulators for Redox Regulation in the Mitochondrial Intermembrane (Grant # MH085683-01) VU Chemistry Team Leader: Corey Hopkins |
University of California Los Angeles |
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A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators (Grant #DA028852-01) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University |
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Cell-based Screen for RGS Activators (Grant # 1 R03 MH087441-01A1) VU Chemistry Team Leader: Corey Hopkins |
University of Michigan |
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Discovery of Small Molecule Probes for Influenza NS1A (Grant# MH089536-01) VU Chemistry Team Leader: Kyle Emmitte |
Southern Research Institute |
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Subtype-Specific Small Molecule Chemical Probe for Non-neuronal KCNQ1 Potassium (Grant# R03 MH090837-01) |
John Hopkins Ion Channel Center
|
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High-throughput multiplex microsphere screening for toxin protease inhibitors (Grant# R03 MH093184-01A1) VU Chemistry Team Leader: Kyle Emmitte |
University of New Mexico |
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HTS for non-canonical ligands for beta-2-adrenergic receptor internalization (Grant# R03 DA031668-01) VU Chemistry Team Leader: Shaun Stauffer |
Carnegie Mellon University |
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Flow cytometry HTS of Small Molecules that Regulate V-ATPase Proton Transport (Grant# R03 DA031666-01A1) VU Chemistry Team Leader: Kyle Emmitte |
University of New Mexico |
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Development of Bioactive Chemicals Probes for Ca-CC (Grant# R03 DA031670-01) VU Chemistry Team Leader: Corey Hopkins |
John Hopkins Ion Channel Center
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A screen for small molecule modulators of human GPCR MrgX1 (Grant # R03 MH095512-01) VU Chemistry Team Leader: Corey Hopkins |
Johns Hopkins University |
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Identification of substances that change alternative pre-mRNA splicing of the ser (Grant# R03MH095431-01) |
University of Kentucky |
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Assay for Small-Molecule Antagonists of the TSH Receptor (follow-up on hit identified during assay validation) (Grant# R03 MH090855) VU Chemistry Team Leader: Mike Wood |
National Institute of Diabetes and Digestive and Kidney Diseases |
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Identification of inhibitors of RAD54, an important DNA repair protein (Grant# R03 DA033981-01A1) VU Chemistry Team Leader: Kyle Emmitte |
Drexel University College of Medicine |
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A high-throughput screen of lytic granule exocytosis (Grant# R21 NS066462) |
University of Connecticut |
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Chemical probes of the astroglial potassium channel Kir4.1 (Grant# R21 NS073097) VU Chemistry Team Leader: Corey Hopkins |
Vanderbilt University Medical Center
|
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ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimer’s Disease (Grant# DA034595) |
Robert Mahley J. David Gladstone Institutes
|
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Small molecule modulators of the two-pore-domain potassium channel, TREK-2-Activator and Inhibitors (Grant# R03 MH097494-01) VU Chemistry Team Leader: Shaun Stauffer |
Vanderbilt University Medical Center
|
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Development of RAD52 inhibitors to induce synthetic lethality of BRCA2- deficient (Grant# 1 R03 MH097512-01) VU Chemistry Team Leader: Kyle Emmitte |
Drexel University College of Medicine |
Center Driven Project - Small Molecule PPI Libraries
Click here for a list of Compound Libraries generated from our center.
