vanderbilt medical center

MLPCN Project Assignments

Chemistry Fast Track Extended Characterization Probe Projects

 


 

Chemistry Fast Track

Project Title
Assay Provider
Screening Center

Discovery of Novel Allosteric Modulators of the D2 Dopamine Receptor (Grant #NS064831-01) 

VU Chemistry Team Leader: Kyle Emmitte

David Sibley

University of New Mexico

Optimization of novel mGluR5 negative allosteric modulators that do not interact with the same site as MPEP and related mGluR5 NAMs (Grant # R01 MH062646) 

VU Chemistry Team Leader: Kyle Emmitte

Jeff Conn and Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

N/A

Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy (Grant # R01 MH062646) 

VU Chemistry Team Leader: Shaun Stauffer

Jeff Conn and Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

N/A

Optimization of novel mGluR3-selective allosteric modulators (Grant # R01 NS031373) 

VU Chemistry Team Leader: Craig Lindsley

Jeff Conn and Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

N/A

Developing isoenzyme selective inhibitors of phospholipase D as an antiviral
therapeutic (Grant # P01-ES013125) 

VU Chemistry Team Leader: Craig Lindsley

Alex Brown

Vanderbilt University Medical Center

N/A

Developing potent and selective CK2 inhibitors as translational tool forfuture regenerative medicine (Grant # 5U01HL100398-02) 

VU Chemistry Team Leader: Corey Hopkins

Charles Hong

Vanderbilt University Medical Center

N/A

Developing potent and selective beta-catenin inhibitors as translational tool for future regenerative medicine (Grant # 5U01HL100398-02)

VU Chemistry Team Leader:  Corey Hopkins

Charles Hong

Vanderbilt University Medical Center

N/A

Developing potent and selective BMP inhibitors as translational tool for future regenerative medicine (Grant # 5U01HL100398-02 ) 

VU Chemistry Team Leader:  Corey Hopkins

Charles Hong

Vanderbilt University Medical Center

N/A

Identification of Novel Modulators of GIRK Channel Activity (Grant # 1R21NS057041-01) 

VU Chemistry Team Leader:  Corey Hopkins

Jerod Denton

Vanderbilt University Medical Center

N/A

Small molecule inhibitors of fluorogen-FAP tag interactions: case study of non-fluorescent analogs of thiazole orange (Grant # 1R03 DA031668-01) 

VU Chemistry Team Leader: Shaun Stauffer

Jonathan Jarvik

Carnegie Mellon University

Optimization and Mechanistic Characterization of Small Molecules that Restore E-cadherin Expression (Grant # 5P50 CA95103-09) 

VU Chemistry Team Leader: Craig Lindsley

Jon Jarvik

Vanderbilt University Medical Center

N/A

Probe Development for Protease Activated Receptor-4 (Grant # 5P50 HL081009-03) 

VU Chemistry Team Leader: Mike Wood

Heidi Hamm

Vanderbilt University Medical Center

N/A

Probe Development for FATP2-mediated Fatty Acid Uptake Inhibition (Grant # 2 R01 DK071076) 

VU Chemistry Team Leader: Shaun Stauffer

Concetta DiRusso

University of Nebraska

N/A

 

Extended Characterization

Project Title
Assay Provider
Screening Center

Chemical optimization of in vitro pharmacology and DMPK properties of the first highly selective mAChR 5 (M5) Positive Allosteric Modulator (PAM) (Grant # X01 MH077607-1)

VU Chemistry Team Leader:  Mike Wood

Jeff Conn and Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

 

N/A

Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (Grant # X01 MH077607-1)

VU Chemistry Team Leader:  Corey Hopkins

Jeff Conn and Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

N/A

Structure-Activity Relationship (SAR) and Chemical Optimization of Advanced mGlu4 Lead Candidates as a Potentially New Treatment Option for Parkinson’s Disease (Grant # NS053536-01)

VU Chemistry Team Leader:  Corey Hopkins

Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

N/A

DMPK and in vivo Studies of the First Sub-Micromolar Disruptor of the Menin-
Mixed Lineage Leukemia (MLL) Interaction by ML227 (Grant # R03MH084875-01A1)

VU Chemistry Team Leader: Shaun Stauffer

Jolanta Grembecka

University of Michigan

N/A

DMPK and in vivo Studies of the Highly Selective Non-Covalent SARS main
proteinase 3CLpro Inhibitor ML188 (Grant # R03 MH084162-01A1)

VU Chemistry Team Leader: Shaun Stauffer

Andy Mesecar

Purdue University

N/A

Extended Characterization of a Novel Chemical Inhibitor of TRPC4 Channels (Grant # NS056942-01)

VU Chemistry Team Leader: Corey Hopkins

Michael Zhu

University of Texas Medical School at Houston

An Enhanced Small Molecule Inhibitor of the KCNQ2 (Kv7.2) Channel (Grant # 1 R03 DA027716-01)

VU Chemistry Team Leader: Corey Hopkins

Min Li

John Hopkins Ion Channel Center

 

Probe Projects

Project Title
Assay Provider
Screening Center

Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen (Grant # MH077606-01)

VU Chemistry Team Leader: Mike Wood

P. Jeffrey Conn/Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

Discovery of Novel Allosteric Agonists of the M4 Muscarinic Receptor: Primary Screen (Grant # MH077607-01)

VU Chemistry Team Leader: Corey Hopkins

Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

Discovery of Novel Allosteric Agonists of the M5 Muscarinic Receptor: Primary Screen (Grant # MH077607-01)

VU Chemistry Team Leader: Mike Wood

Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

A direct assay for HTS of Gi/Go-linked GPCRs: mGluR8 as the prototype (Grant # NS053536-01)

VU Chemistry Team Leader: Corey Hopkins

Colleen Niswender

Vanderbilt Center for Neuroscience Drug Discovery

Small Molecule Modulators for Redox Regulation in the Mitochondrial Intermembrane (Grant # MH085683-01)

VU Chemistry Team Leader:  Corey Hopkins

Carla Koehler

University of California Los Angeles

A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators (Grant #DA028852-01) 

VU Chemistry Team Leader: Corey Hopkins

Alicia Ruggiero

Vanderbilt University

Cell-based Screen for RGS Activators (Grant # 1 R03 MH087441-01A1) 

VU Chemistry Team Leader: Corey Hopkins

Richard Neubig

University of Michigan

Discovery of Small Molecule Probes for Influenza NS1A (Grant# MH089536-01) 

VU Chemistry Team Leader: Kyle Emmitte

Colleen Jonsson

Southern Research Institute

Subtype-Specific Small Molecule Chemical Probe for Non-neuronal KCNQ1 Potassium (Grant# R03 MH090837-01) 

VU Chemistry Team Leader: Corey Hopkins

Min Li

John Hopkins Ion Channel Center

 

High-throughput multiplex microsphere screening for toxin protease inhibitors (Grant# R03 MH093184-01A1) 

VU Chemistry Team Leader: Kyle Emmitte

Steven Graves

University of New Mexico

HTS for non-canonical ligands for beta-2-adrenergic receptor internalization (Grant# R03 DA031668-01) 

VU Chemistry Team Leader: Shaun Stauffer

Jonathan Jarvik

Carnegie Mellon University

Flow cytometry HTS of Small Molecules that Regulate V-ATPase Proton Transport (Grant# R03 DA031666-01A1) 

VU Chemistry Team Leader: Kyle Emmitte

Karlett Parra

University of New Mexico

Development of Bioactive Chemicals Probes for Ca-CC (Grant# R03 DA031670-01) 

VU Chemistry Team Leader: Corey Hopkins

Min Li

John Hopkins Ion Channel Center

 

A screen for small molecule modulators of human GPCR MrgX1 (Grant # R03 MH095512-01

VU Chemistry Team Leader: Corey Hopkins

Xinzhong Dong

Johns Hopkins University

Identification of substances that change alternative pre-mRNA splicing of the ser (Grant# R03MH095431-01)

VU Chemistry Team Leader: Kyle Emmitte

Stefan Stam

University of Kentucky

Assay for Small-Molecule Antagonists of the TSH Receptor (follow-up on hit identified during assay validation) (Grant# R03 MH090855)

VU Chemistry Team Leader: Mike Wood

Marvin Gershengorn

National Institute of Diabetes and Digestive and Kidney Diseases

Identification of inhibitors of RAD54, an important DNA repair protein (Grant# R03 DA033981-01A1)

VU Chemistry Team Leader: Kyle Emmitte

Alexander Mazin

Drexel University College of Medicine

A high-throughput screen of lytic granule exocytosis (Grant# R21 NS066462)

VU Chemistry Team Leader: Mike Wood

Adam Zweifach

University of Connecticut

Chemical probes of the astroglial potassium channel Kir4.1 (Grant# R21 NS073097)

VU Chemistry Team Leader: Corey Hopkins

Jerod Denton

Vanderbilt University Medical Center

 

ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimer’s Disease (Grant# DA034595)

VU Chemistry Team Leader: Mike Wood

Robert Mahley

J. David Gladstone Institutes

 

Small molecule modulators of the two-pore-domain potassium channel, TREK-2-Activator and Inhibitors (Grant# R03 MH097494-01)

VU Chemistry Team Leader: Shaun Stauffer

David Jacobson

Vanderbilt University Medical Center

 

Development of RAD52 inhibitors to induce synthetic lethality of BRCA2- deficient (Grant# 1 R03 MH097512-01)

VU Chemistry Team Leader: Kyle Emmitte

Alexander Mazin

Drexel University College of Medicine

 

Center Driven Project - Small Molecule PPI Libraries

Click here for a list of Compound Libraries generated from our center.