Center for Matrix Biology - Vanderbilt University and Medical Center

John P. Wikswo, Ph.D.
University Professor in the Department of Molecular Physiology & Biophysics

	Office Address:	VU Station B 351807
	Mailing Address:	VU Station B 351807 Nashville, TN
	Lab address:	6809 Stevenson Center
	Phone:	(615) 343-4124
	FAX:	615 322 4977
		email \| website

Secondary appointment in the Biomedical Engineering department.
Secondary appointment in the Physics department.

Research Summary

John Wikswo and his group are at present working in three areas: the study of the linear and non-linear electrical properties of cardiac tissue during stimulation, propagation, and recovery for threshold- and defibrillation-strength shocks; the magnetic measurement of cellular action currents in cardiac and intestinal tissue, as can be observed using SQUID magnetometry; and the development and application of micro- and nano-scale devices for instrumenting and controlling the single biological cell and small populations of cells. His long-term program to understand the effects of defibrillation-strength shocks on cardiac tissue now includes studies of charge and electroporation and molecular diffusion. The magnetic studies of action currents range from determining the information content of the magnetocardiogram in isolated rabbit hearts to the non-invasive diagnosis of intestinal ischemia in humans. The project to instrument and control single cells is addressing issues as varied as the use of cells to identify and discriminate chemical and biological warfare agents by metabolic phenotype; the development and application of BioMEMS (BioMicroElectroMechanical Systems) devices to understand the molecular signaling associated with chemotaxis, cellular motility, angiogenesis, and metastasis; and the nature of the signaling and metabolic activity associated with the immune response.

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Associated initiative(s):

Biomaterials

Tissue Regeneration

Tumor Microenvironment

Career opportunities:
None currently available

Selected Publications

» M.R. Holcomb, M.C. Woods, I. Uzelac, J.P. Wikswo, J.M. Gilligan, and V.Y. Sidorov "The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism" Experimental Biology and Medicine 2009. DOI: 10.3181/0902-RM-47. 234:1355-1373

» A. Irimia, K.R. Swinney, and J.P. Wikswo "Partial Independence of Bioelectric and Biomagentic Fields and Its Implications for Encephalography and Cardiography" Phys. Rev. E. 2009. DOI: 10.1103/PhysRevE.79.051908. 79:051908-1-051908-13

» R.A. Gray, J.P. Wikswo, and N.F. Otani "Origin Choice and Petal Loss in the Flower Garden of Spiral Wave Tip Trajectories" Chaos 2009. DOI: 10.1063/1.3204256. 19:033118-1-03118-8

» S.L. Faley, M. Copland, D. Wlodkowic, W. Kolch, K.T. Seale, J.P. Wikswo, and J.M. Cooper "Microfluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-derived Hematopoietic Stem Cells" Lab Chip 2009. DOI: 10.1039/b902083g. 9:2659-2664

» K.T. Seale, C. Janetopoulos, and J.P. Wikswo Micro-Mirrors for Nanoscale Three-Dimensional Microscopy ACS Nano 2009. 3:493-497

» S.E. Eklund, R.G. Thompson, R.M. Snider, C.K. Carney, D.W. Wright, J.P. Wikswo, and D.E. Cliffel "Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer" Sensors 2009. 9:2117-2133

» J.P. Wikswo and B.J. Roth "Virtual Electrode Theory of Pacing" In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, I. Efimov, M. Kroll, and P. Tchou, Eds., (Springer) 2009. Chapter 4.3:pp. 283-330

» V.Y. Sidorov, M.R. Holcomb, M.C. Woods, R.A. Gray, and J.P. Wikswo "Effects of Unipolar Stimulation on Voltage and Calcium Distributions in the Isolated Rabbit Heart" Basic Research in Cardiology 2008.DOI: 10.1007/s00395-008-0740-1 . 103:537-551

» K.A. Addae-Mensah and J.P. Wikswo "Measurement Techniques for Cellular Biomechanics in Vitro" Experimental Biology and Medicine 2008. DOI: 10.3181/0710-MR-278. 233:792-809

» M.M. Maleckar, M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.N. Mashburn, J.P. Wikswo, and N.A. Trayanova "Polarity Reversal Lowers Activation Time During Diastolic Field Stimulation of the Rabbit Ventricles: Insights Into Mechanisms" Am. J. Physiol.-Heart Circ. Physiol. 2008. DOI: 10.1152/ajpheart.00706.2008. 295:H1626-H1633

» D.W. Evertson, M.R. Holcomb, M. Eames, M. Bray, V.Y. Sidorov, J. Xu, H. Wingard, H.M. Dobrovolny, M.C. Woods, D.J. Gauthier, and J.P. Wikswo "High-Resolution High-Speed Panoramic Cardiac Imaging System" IEEE Trans. BME 2008. DOI: 10.1109/TBME.2007.912417. 55:1241-1243

» R.A. Abbas, S.-F. Lin, D. Mashburn, J. Xu, and J.P. Wikswo "A Phased-Array Stimulator System for Studying Planar and Curved Cardiac Activation Wavefronts" IEEE Trans. BME 2008. DOI: 10.1109/TBME.2007.901039. 55:222-229

» M.R. Holcomb, R.Y. Bekele, E.A. Lima, and J.P. Wikswo "Universal Serial Bus Powered and Controlled Isolated Constant-Current Physiological Stimulator" Rev. Sci. Instrum. 2008. DOI: 10.1063/1.3030861. 79:126103-1-126103-3

» J. Xu , R. Reiserer, J. Tellinghuisen, J.P. Wikswo, and F.J. Baudenbacher "A Microfabricated Nanocalorimeter: Design, Characterization, and Chemical Calibration" Analytical Chemistry 2008. DOI: 10.1021/ac702213d. 80:2727-2733

» B.R. Gorman and J.P. Wikswo "Characterization of Transport in Microfluidic Gradient Generators" Microfluid Nanofluid 2008. 4:273-285

» A. Irimia and John P. Wikswo, Jr "Gastrointestinal Arrhythmias Are Associated With Statistically Significant Fluctuations in Systemic Information Dimension" Physiol. Meas. 2008. 29:N33-N40

» M.P. Harris, E. Kim, B. Weidow, J.P. Wikswo, and V. Quaranta "Migration of Isogenic Cell Lines Quantified by Dynamic Multivariate Analysis of Single-Cell Motility" Cell Adhesion & Migration 2008. 2:127-136

» S. Faley, K. Seale, J. Hughey, D.K. Schaffer, S. VanCompernolle, B. McKinney, F. Baudenbacher, D. Unutmaz, and J.P. Wikswo "Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel" Lab Chip 2008. 8:1700-1712

» W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, G.L. Taghon, and D.S. Kosson "Protozoan Migration in Bent Microfluidic Channels" Applied and Environmental Microbiology 2008. 74:1945-1949

» J. Sai, D. Raman, Y. Liu, J. Wikswo, and A. Richmond "Parallel PI3K-Dependent and Src-Dependent Pathways Lead to CXCL8-Mediated Rac2-Activation and Chemotaxis" J. Biological Chemistry 2008. 283:26538-26547

» K.T. Seale, R.S. Reiserer, D.A. Markov, I.A. Ges, C. Wright, C. Janetopoulos, and J.P. Wikswo "Mirrored Pyramidal Wells for Simultaneous Multiple Vantage Point Microscopy" J. Microscopy 2008. 232:1-6

» Y. Liu, J. Sai, A. Richmond, and J. Wikswo "Microfluidic Switching System for Analyzing Chemotaxis Responses of Wortmannin-Inhibited HL-60 Cells" Biomedical Microdevices 2008. 10:499-507

» J.S. Gruver, J.P. Wikswo, and C.Y. Chung "3-Phosphoinositides Regulate the Coordination of Speed and Accuracy During Chemotaxis" Biophys. J. 2008. 95:4057-4067

» W. Georgescu, J. Jourquin, L. Estrada, A.R.A. Anderson, V. Quaranta, and J.P. Wikswo "Model-Controlled Hydrodynamic Focusing to Generate Multiple Overlapping Gradients of Surface-Immobilized Proteins in Microfluidic Devices" Lab Chip 2008. 8:238-244

» K.A. Addae-Mensah, R.S. Reiserer, and J.P. Wikswo "Poly(Vinyl Alcohol) as a Structure Release Layer for Microfabrication of Polymer Composite Structures" J. Micromech. Microeng. 2007. 17:N41-N46

» D.F. Salisbury, A. Price, R.D. Collins, and J.P. Wikswo "Max at Vanderbilt" Max Delbruck and the New Perception of Biology, 1906-1981: A Centenary Celebration 2007. University of Salamanca, October 9-10, 2006, W. Shropshire, Jr., Ed. (AuthorHouse, Bloomington, IN):Chapter 22, pp. 213-235

» K.A. Addae-Mensah, N.J. Kassenbaum, M.J. Bowers II, R.S. Reiserer, S.J. Rosenthal, P.E. Moore, and J.P. Wikswo "A Flexible, Quantum Dot-Labeled Cantilever Post Array for Studying Cellular Microforces" Sensors and Actuators 2007. 136:385-397

» S. Huang and J. Wikswo "Dimensions of Systems Biology" Reviews of Physiology, Biochemistry, and Pharmacology 2007. 157:81-104

» D.N. Mashburn, S.J. Hinkson, M.C. Woods, J.M. Gilligan, M.R. Holcomb, and J.P. Wikswo "A High Voltage Cardiac Stimulator for Field Shocks of a Whole Heart in a Bath" Rev. Sci. Instrum. 2007. 78:104302

» S.K. Vajandar, D. Xu, D.A. Markov, J.P. Wikswo, W. Hofmeister, and D. Li "SiO2-Coated Porous Anodic Alumina Membranes for High Flow Rate Electroosmotic Pumping" Nanotechnology 2007. 18:275705

» J. Wikswo, A. Prokop, F. Baudenbacher, D. Cliffel, B. Csukas, and M. Velkovsky "Engineering Challenges of BioNEMS: The Integration of Microfluidics, and Micro- and Nanodevices, Models, and External Control for Systems Biology" IEE Proc. Nanobiotechnology 2006. DOI: 10.1049/ip-nbt:20050045. 153(4):81-101

» E. Juzeliunas, Y.P. Ma, and J.P. Wikswo "Magnetometric Corrosion Sensing Under Hydrodynamic Conditions" J. Solid State Electrochemistry 2006. 10:700-707

» E.A. Lima, A. Irimia, and J.P. Wikswo, Jr "The Magnetic Inverse Problem" The SQUID Handbook, J. Clarke and A. Braginski, Eds., (Wiley-VCH, Verlag, Berlin) 2006. Vol. 2, Chap. 10:pp. 139-267

» S.E. Eklund, J. Wikswo, F. Baudenbacher, A. Prokop, and D.E. Cliffel "Multianalyte Microphysiometry as a Tool in Metabolomics and Systems Biology" J. Electroanalytical Chemistry 2006. 587:333-339

» R.A. Gray, A. Iyer, M.-A. Bray, and J.P. Wikswo "Voltage-Calcium State-Space Dynamics During Initiation of Reentry" Heart Rhythm 2006. 3:247-248

» R.A. Malkin, D.X. Guan, and J.P. Wikswo "Experimental Evidence of Improved Transthoracic Defibrillation with Electroporation-Type Pulses" IEEE Trans. BME 2006. 53(10):1901-1910

» M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.L. Beaudoin, B.J. Roth, and J.P. Wikswo "Virtual Electrode Effects Around an Artificial Heterogeneity During Field Stimulation of Cardiac Tissue" Heart Rhythm 2006. 3:751-752

» J. Sai, G. Walker, J. Wikswo, and A. Richmond "The IL Sequence in the LLKIL Motif in CXCR2 is Required for Full Ligand Induced Activation of Erk, Akt and Chemotaxis in HL60 Cells" J. Biol. Chem. 2006. 281(47):35931-35942

» M.R. Warnement, S.L. Faley, J.P. Wikswo, and S.J. Rosenthal "Quantum Dot Probes for Monitoring Dynamic Cellular Response: Reporters of T Cell Activation" IEEE Trans. NanoBioscience 2006. 5(4):268-272

» Z. Yang, W. Shen, J.N. Rottman, J.P. Wikswo, and K.T. Murray "Rapid Stimulation Causes Electrical Remodeling in Cultured Atrial Myocytes" J. Mol. Cell. Cardiol. 2005. DOI: 10.1016/j-yjmcc.2004.11.015. 38:299-308

» G.M. Walker, J. Sai, A. Richmond, M. Stremler, C.Y. Chung, and J.P. Wikswo "Effects of Flow and Diffusion on Chemotaxis Studies in a Microfabricated Gradient Generator" Lab-on-a-Chip 2005. 5:611-618

» L.A. Bradshaw, O.P. Roy, G.P. O'Mahony, A.G. Myers, J.G. McDowell, J.P. Wikswo, and W.O. Richards "Biomagnetic Detection of Injury Currents in Rabbit Ischemic Intestine" Dig. Dis. Sci. 2005. 50:1561-1568

» W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, and D.S. Kosson "Mobility of Protozoa Through Narrow Channels" Appl. Environ. Microbiol. 2005. 71:4628-4637

» L.A. Bradshaw, A. Myers, W.O. Richards, W., Drake, and J.P. Wikswo "Vector Projection of Biomagnetic Fields" Med. Biol. Eng. Comput. 2005. 43:85-93

» A.A. Werdich, E.A. Lima, B. Ivanov, I. Ges, J.P. Wikswo, and F.J. Baudenbacher "A Microfluidic Device to Confine a Single Cardiac Myocyte in a Sub-Nanoliter Volume on a Planar Microelectrode Array for Cellular Activity Detection" Lab Chip 2004. DOI: 10.1039/b315648f. 4:357-362

» J.R. Holzer, L.E. Fong, V.Y. Sidorov, J.P. Wikswo, and F. Baudenbacher "High Resolution Magnetic Images of Planar Wave Fronts Reveal Bidomain Properties of Cardiac Tissue" Biophys. J. 2004. 87:4326-4332

» E. Juzeliũnas, Y.P. Ma, and J.P. Wikswo "Remote Sensing of Aluminum Alloy Corrosion by SQUID Magnetometry" J. Solid State Electrochem. 2004. 8:435-441

» A. Prokop, Z. Prokop, D. Schaffer, E. Kozlov, J.P. Wikswo, D. Cliffel, and F. Baudenbacher "NanoLiterBioReactor: Monitoring of Long-Term Mammalian Cell Physiology at Nanofabricated Scale" Biomedical Microdevices 2004. 6:325-339

» J.P. Wikswo "SQUIDs Remain Best Tools for Measuring Brains Magnetic Field" Physics Today 2004. 52:15-17

» E.B. Chancellor, J.P. Wikswo, F. Baudenbacher, M. Radparvar, and D. Osterman "Heat Conduction Calorimeter for Massively Parallel High Throughput Measurements with Picoliter Sample Volumes" Applied Physics Letters 2004. 85:2408-2410

» K.R. Cooper, Y. Ma, J.P. Wikswo, and R.G. Kelly "Simultaneous Monitoring of the Corrosion Activity and Moisture Inside Aircraft Lap Joints" Corrosion Engineering, Science and Technology 2004. 39:339-345

» M.-A. Bray and J.P. Wikswo "Interaction Dynamics of a Pair of Vortex Filament Rings" Phys. Rev. Lett. 2003. 90:238303-1-238303-4

» V.Y. Sidorov, R.R. Aliev, M.C. Woods, F. Baudenbacher, P. Baudenbacher, and J.P. Wikswo "Spatiotemporal Dynamics of Damped Propagation in Excitable Cardiac Tissue" Phys. Rev. Lett. 2003. 91:208104-1-208104-4

» S.E. Eklund, D.E. Cliffel, E. Kozlov, A. Prokop, J. Wikswo, and F. Baudenbacher "Modification of the CytosensorTM Microphysiometer to Simultaneously Measure Extracellular Acidification and Oxygen Consumption Rates" Analytica Chimica Acta 2003. 496:93-101

» L.A. Bradshaw, A.G. Myers, A. Redmond, J.P. Wikswo, and W.O. Richards "Biomagnetic Detection of Gastric Electrical Activity in Normal and Vagotomized Rabbits" Neurogastroenterol. Motil. 2003. 15:475-482

» M.-A. Bray and J.P. Wikswo "Examination of Optical Depth Effects on Fluorescence Imaging of Cardiac Propagation" Biophys. J. 2003. 85:4134-4145

» L.A. Bradshaw, A.G. Myers, J.P. Wikswo, Jr., and W.O. Richards "A SpatioTemporal Dipole Simulation of Gastriointestinal Magnetic Fields" IEEE Trans. Biomed. Engr. 2003. 50:836-847

» V.Y. Sidorov, M.C. Woods, and J.P. Wikswo "Effects of Elevated Extracellular Potassium on the Stimulation Mechanism of Diastolic Cardiac Tissue" Biophys. J. 2003. 84:3470-3479

» J.K. Ladipo, S.A. Seidel, L.A. Bradshaw, S. Halter, J.P. Wikswo, and W.O. Richards "Histopathologic Changes During Mesenteric Ischemia and Reperfusion" West Afr. J. Med. 2003. 22:59-62

» F. Baudenbacher, N.T. Peters, P. Baudenbacher, and J.P. Wikswo "High Resolution Imaging of Biomagnetic Fields Generated by Action Currents in Cardiac Tissue Using a LTS-SQUID Microscope" Physica C 2002. 368:24-31

» M.-A. Bray and J.P. Wikswo "Use of Topological Charge to Determine Singularity and Filament Location in a Numerical Model of Scroll Wave Activity" IEEE Trans. BME 2002. 49:1086-1093

» F. Baudenbacher, N.T. Peters, and J.P. Wikswo, Jr "High Resolution Low-Temperature Superconductivity SQUID Microscopes for Imaging Magnetic Fields of Samples at Room Temperature" Rev. Sci. Instrum. 2002. 73:1247-1254

» M.A. Bray, J.P. Wikswo "Considerations in Phase Plane Analysis for Nonstationary Reentrant Cardiac Behavior" Phys. Rev. E 2002. 65:051902-1-051902-8

» M.-A. Bray and J.P. Wikswo, Jr "Three-Dimensional Visualization of Phase Singularities on the Isolated Rabbit Heart" J. Cardiovas. Electrophysiol. 2002. 13:1311

» G. Choudhury, W.G. Jenks, J.P. Wikswo, Jr., and C.G. Bublitz "Effects of Parasite Attributes and Injected Current Parameters on Electromagnetic Detection of Parasites in Fish Muscle" J. Food Science: Food Engineering and Physical Properties 2002. 67:3381-3387

» Y.P. Ma, J.P. Wikswo, M. Samuleviiene, K. Leinartas, and E. Juzeliunas "Magnetic Fields Induced by Electrochemical Reactions: Aluminum Alloy Corrosion Sensing by SQUID Magnetometry on a Macroscopic Scale" J. Phys. Chem. B 2002. 106:12549-12555

» L.A. Bradshaw, R.S. Wijesinghe, and J.P. Wikswo, Jr "Spatial Filter Approach for Comparison of the Forward and Inverse Problems of Electroencephalography and Magnetoencephalography" Annals of Biomed. Eng. 2001. 29:214-226

» M.-A. Bray, S.-F.Lin, R.R. Aliev, B.J. Roth, and J.P. Wikswo, Jr "Experimental and Theoretical Analysis of Phase Singularity Dynamics in Cardiac Tissue" J. Cardiovasc. Electrophysiol. 2001. 12:716-722

» K.K. Parker, L.K. Taylor, J.B. Atkinson, D.E. Hansen, and J.P. Wikswo, Jr "The Effects of Tubulin-Binding Agents on Stretch-Induced Ventricular Arrhythmias" European Journal of Pharmacology 2001. 417:131-140

» L.A. Bradshaw and J.P. Wikswo, Jr "Spatial Filter Approach for Evaluation of the Surface Laplacian of the Electroencephalogram and Magnetoencephalogram" Annals of Biomed. Eng. 2001. 29:202-213

» S.-F. Lin and J.P. Wikswo, Jr "New Perspectives in Electrophysiology from the Cardiac Bidomain" In: Optical Mapping of Cardiac Excitation and Arrhythmias 2001. D.S. Rosenbaum and J. Jalife, Eds., :pp. 335-359

» B.P. Weiss, F.J. Baudenbacher, J.P. Wikswo, and J.L. Kirschvink "Magnetic Microscopy Promises a Leap in Sensitivity and Resolution" EoS 2001. 82:513-518

» L.A. Bradshaw, W.O. Richards, and J.P. Wikswo, Jr "Volume Conductor Effects on the Spatial Resolution of Magnetic Fields and Electric Potentials from Gastrointestinal Electrical Activity" Med. Biol. Eng. Comput. 2001. 39:35-43

» J.P. Wikswo "Applications of SQUID Magnetometers to Biomagnetism and Nondestructive Evaluation" In: Applications of Superconductivity 2000. H. Weinstock, Ed., :pp. 139-228

» M.-A. Bray, S.-F. Lin, and J.P. Wikswo, Jr "Three-Dimensional Surface Reconstruction and Fluorescent Visualization of Cardiac Activation" IEEE Trans. BME 2000. 47:1382-1391

» B.P. Weiss, J.L. Kirschvink F.J. Baudenbacher, H. Vali, N.T. Peters, F.A. Macdonald, and J.P. Wikswo, Jr "A Low-Temperature Transfer of ALH84001 from Mars to Earth" Science 2000. 290:791-795

» J. Wu, D.M. Roden, and J.P. Wikswo, Jr "Delayed Activation and Retrograde Propagation in Cardiac Muscle: Implication of Virtual Electrode Effects" Annals of Biomed. Eng. 2000. 28:1318-1325

» G. Skennerton, A. Abedi, R.G. Kelly, and J.P. Wikswo, Jr "Magnetic Measurements of the Response of Corrosion Activity within Aircraft Lap Joints to Accelerated Corrosion Testing" J. Corrosion Science and Engr., on http:// www.cp.umist.ac.uk/jcse/vol3/paper2/v3p2.html 2000. :

» R.R. Aliev, W.O. Richards, and J.P. Wikswo, Jr "A Simple Non-Linear Model of Electrical Activity in the Intestine" J. Theor. Biology 2000. 204:21-28

» L.A. Bradshaw, J.K. Ladipo, D.J. Staton, J.P. Wikswo, and W.O. Richards "The Human Vector Magnetogastrogram and Magnetoenterogram" IEEE Trans. Biomed. Eng. 1999. 46:959-970

» T.A. Cruse, A.P. Ewing, and J.P. Wikswo, Jr "Green's Function Formulation of Laplace's Equation for Electromagnetic Crack Detection" Computational Mechanics 1999. 23:420-429

» J.R. Kirtley and J.P. Wikswo, Jr "Scanning SQUID Microscopy" Annu. Rev. Mater. Sci. 1999. 29:117-148

» S.F. Lin, B.J. Roth, and J.P. Wikswo, Jr "Quatrefoil Reentry in Myocardium: An Optical Imaging Study of the Induction Mechanism" J. Cardiovasc. Electrophysiol. 1999. 10:574-586

» S.F. Lin and J.P. Wikswo, J "Panoramic Optical Imaging of Electrical Propagation in Isolated Heart" J. Biomed. Opt. 1999. 4:200-207

» S.A. Seidel, L.A. Bradshaw, J.K. Ladipo, J.P. Wikswo, Jr., and W.O. Richards "Noninvasive Detection of Ischemic Bowel" J. Vascular Surgery 1999. 30:309-319

» A. Abedi, J.J. Fellenstein, A.J. Lucas, and J.P. Wikswo, Jr "A SQUID Magnetometer System for Quantitative Analysis and Imaging of Hidden Corrosion Activity in Aircraft Aluminum Structures" Rev. Sci. Instrum. 1999. 70:4640-4651

» B.J. Roth, S.-F. Lin, and J.P. Wikswo, Jr "Unipolar Stimulation of Cardiac Tissue" J. Electrocardiol. 1998. 31:6-12

» B.J. Roth and J.P. Wikswo "Comments on 'Hall-Effect Imaging'" IEEE Trans. BME 1998. 45:1294-1296

» S.H. Allos, D.J. Staton, L.A. Bradshaw, S. Halter, J.P. Wikswo, Jr., and W.O. Richards "Superconducting Quantum Interference Device Magnetometer for Diagnosis of Ischemia Caused by Mesenteric Venous Thrombosis" World J. Surg. 1997. 21:173-178

» S.F. Lin, R.A. Abbas, and J.P. Wikswo, Jr "High-Resolution High-Speed Synchronous Epifluorescence Imaging of Cardiac Activation" Rev. Sci. Instr. 1997. 68:213-217

» D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr "Detection of Hidden Corrosion of Aircraft Aluminum Alloys by Magnetometry Using a Superconducting Quantum Interference Device" Corrosion 1997. 53:93-98

» L.A. Bradshaw, S.H. Allos, J.P. Wikswo, Jr., and W.O. Richards "Correlation and Comparison of Magnetic and Electric Detection of Small Intestinal Electrical Activity" Am. J. Physiol. 1997. 272:G1159-G1167

» K.K. Parker and J.P. Wikswo, Jr "A Model of the Magnetic Fields Created by Single Motor Unit Compound Action Potentials in Skeletal Muscle" IEEE Trans. Biomed. Eng. 1997. 44:948-957

» J. Wu and J.P. Wikswo "Effects of Bath Resistance on Action Potentials in the Squid Giant Axon: Myocardial Implications" Biophys. J. 1997. 73:2347-2358

» W.G. Jenks, S.S.H. Sadeghi, and J.P. Wikswo, Jr "SQUIDs for Non-Destructive Evaluation" J. Physics D: Applied Physics 1997. 30:293-323

» W.G. Jenks, I.M. Thomas, and J.P. Wikswo, Jr "SQUIDs" Encyclopedia of Applied Physics 1997. G.L. Trigg, E.S. Vera, and W. Greulich, Eds., :pp. 457-468

» B.J. Roth and J.P. Wikswo, Jr "The Effect of Externally Applied Electrical Fields on Myocardial Tissue" Proceedings of the IEEE 1996. 84:379-391

» J.P. Wikswo, Jr "The Magnetic Inverse Problem" In: SQUID Sensors: Fundamentals, Fabrication and Applications 1996. H. Weinstock, Ed.,:pp. 629-695

» N.G. Sepulveda and J.P. Wikswo, Jr "A Numerical Study of the Use of Magnetometers to Detect Hidden Flaws in Conducting Objects" J. Applied Physics 1996. 79:2122-2135

» S. Tan, Y.P. Ma, I.M. Thomas, and J.P. Wikswo, Jr "Reconstruction of Two-Dimensional Magnetization and Susceptibility Distributions from the Magnetic Field of Soft Magnetic Materials" IEEE Trans. Mag. 1996. 32:230-234

» W.O. Richards, L.A. Bradshaw, D.J. Staton, C.L. Garrard, F. Liu, S. Buchanan, and J.P. Wikswo, Jr "Magnetoenterography (MENG): Noninvasive Measurement of Bioelectric Activity in Human Small Intestine" Digestive Diseases and Sciences 1996. 41:2293-2301

» W.G. Jenks, C.G. Bublitz, G.S. Choudhury, Y.P. Ma, and J.P. Wikswo, Jr "Detection of Parasites in Fish by Superconducting Quantum Interference Device Magnetometry" Journal of Food Science 1996. 61:865-869

» P.H. Bunton, W.P. Henry, and J.P. Wikswo, Jr "A Simple Integrated Circuit Model of Propagation Along an Excitable Axon" Am. J. Phys. 1996. 64:602-606

» D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr "Application of Superconducting Magnetometry in the Study of Aircraft Aluminum Alloy Corrosion" Corrosion 1996. 52:219-231

» J.P. Wikswo, Jr "High-Resolution Magnetic Imaging: Cellular Action Currents and Other Applications" In: SQUID Sensors: Fundamentals, Fabrication and Applications 1996. H. Weinstock, Ed., :pp. 307-360

» J.P. Wikswo, Jr "SQUID Magnetometers for Biomagnetism and Non-Destructive Testing: Important Questions and Initial Answers" IEEE Trans. on Applied Supercond. 1995 (Plenary Lecture). 5:74-120

» D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr "Detecting In-Situ Active Corrosion by a SQUID Magnetometer" Journal of Minerals, Metals, and Materials 1995. 47:36-39

» S. Tan, N.G. Sepulveda, and J.P. Wikswo, Jr "A New Finite-Element Approach to Reconstruct a Bounded and Discontinuous Two-Dimensional Current Image From a Magnetic Field Map" J. Comp. Phys. 1995. 122:150-164

» W.O. Richards, C.L. Garrard, S.H. Allos, L.A. Bradshaw, D.J. Staton, and J.P. Wikswo, Jr "Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer" Annals of Surgery 1995. 221:696-705

» J.P. Wikswo, Jr "Tissue Anisotropy, the Cardiac Bidomain and the Virtual Cathode Effect" In: Cardiac Electrophysiology: From Cell to Bedside, Second Edition, D.P. Zipes and J. Jalife, Eds. 1995. :348-361

» N.G. Sepulveda and J.P. Wikswo, Jr "Line Follower for Finite Element Post-Processing and Current Imaging" Communications in Numerical Methods and Engineering 1995. 11:1025-1032

» J.P. Wikswo, Jr., S.F. Lin, and R.A. Abbas "Virtual Electrodes in Cardiac Tissue: A Common Mechanism for Anodal and Cathodal Stimulation" Biophys. J. 1995. 69:2195-2210

» Y.P. Ma and J.P. Wikswo, Jr "Techniques for Depth-Selective, Low-Frequency Eddy Current Analysis for SQUID-Based Non-Destructive Testing" J. Nondestr. Eval. 1995. 14:149-167

» J. Golzarian, D.J. Staton, J.P. Wikswo, Jr., R.N. Friedman, and W.O. Richards "Diagnosing Intestinal Ischemia Using a Noncontact Superconducting Quantum Interference Device" Am. J. Surgery 1994. 167:586-592

» B.J. Roth, P.J. Basser and J.P. Wikswo, Jr "A Theoretical Model of Magneto-Acoustic Imaging of Bioelectric Currents" IEEE Trans. Biomed. Eng. 1994. 41:723-728

» B.J. Roth and J.P. Wikswo, Jr "Electrical Stimulation of Cardiac Tissue: A Bidomain Model With Active Membrane Properties" IEEE Trans. Biomed. Eng. 1994. 41:232-240

» N.G. Sepulveda, I.M. Thomas, and J.P. Wikswo, Jr "Magnetic Susceptibility Tomography for Three-Dimensional Imaging of Diamagnetic and Paramagnetic Objects" IEEE Trans. Mag. 1994. 30:5062-5069

» J.P. Barach and J.P. Wikswo, Jr "Magnetic Fields From Simulated Cardiac Action Currents" IEEE Trans. Biomed. Eng. 1994. 41:969-974

» N.G. Sepulveda and J.P. Wikswo, Jr "Bipolar Stimulation of Cardiac Tissue Using an Anisotropic Bidomain Model" J. Cardiovasc. Electrophys. 1994. 5:258-267

» J.P. Wikswo "The Complexities of Cardiac Cables: Virtual Electrode Effects" Biophys. J. 1994. 66:551-553

» J.P. Wikswo, Jr. and S.J. Williamson "Biomagnetism" 1994 McGraw-Hill Yearbook of Science & Technology 1994. :pp. 48-51

» D.C. Hurley, Y.P. Ma, S. Tan, and J.P. Wikswo, Jr "Imaging of Small Defects in Nonmagnetic Tubing Using a SQUID Magnetometer" Res. Nondestr. Eval. 1993. 5:1-29

» J.M. van Egeraat, R. Stasaski, J.P. Barach, R.N. Friedman, and J.P. Wikswo, Jr "The Biomagnetic Signature of a Crushed Axon: A Comparison of Theory and Experiment" Biophys. J. 1993. 64:1299-1305

» J.M. van Egeraat and J.P. Wikswo, Jr "A Model for Axonal Propagation Incorporating Both Radial and Axial Ionic Transport" Biophys. J. 1993. 64:1287-1298

» J.P. Wikswo, Jr., D.B. Crum, W.P. Henry, Y.P. Ma, N.G. Sepulveda, and D.J. Staton "An Improved Method for Magnetic Identification and Localization of Cracks in Conductors" J. Nodestr. Eval. 1993. 12:109-119

» S.F. Lin, R.A. Abbas, and J.P. Wikswo "Magnetic Locailization of the Origin of Self-Sustained Oscillation in SQUID Giant Axons" Biol. Bull. 1993. 185:300-301

» I.M. Thomas, S.M. Freake, S.J. Swithenby, and J.P. Wikswo, Jr. "A Distributed Quasi-static Ionic Current Source in the 3-4 Day Old Chicken Embryo" Phys. Med. Biol. 1993. 38:1311-1328

» J.P. Wikswo, A. Gevins, and S.J. Williamson "The Future of the EEG and MEG" Electroencephalogr. Clin. Neurophysiol. 1993. 87:1-9

» I.M. Thomas, T.C. Moyer, and J.P. Wikswo, Jr "High Resolution Magnetic Susceptibility Imaging of Geological Thin Sections: Pilot Study of a Pyroclastic Sample from the Bishop Tuff" Geophys. Res. Letters 1992. 19:2139-2142

» J.P. Wikswo, Jr. and S.J. Williamson "Magnetic Source Imaging: Cell, Tissue, and Brain" In: Physics News in 1991, P.F. Schewe, Ed. 1992. :pp. 21-24

» J.P. Barach and J.P. Wikswo, Jr "A Numerical Reconstruction of the Effects of Late Stimulation on a Cardiac Ventricular Action Potential" Comp. & Biomed. Res. 1992. 25:212-217

» J. Turgeon, T.A. Wisialowski, W. Wong, W.A. Altemeier, J.P. Wikswo, Jr., and D.M. Roden "Suppression of Longitudinal Versus Transverse Conduction by Sodium Channel Block: Effects of Sodium Bolus" Circulation 1992. 85:2221-2226

» N.G. Sepulveda, D.J. Staton, and J.P. Wikswo, Jr "A Mathematical Analysis of the Magnetic Field Produced By Flaws in Two-Dimensional Current-Carrying Conductors" J. Nondestr. Eval. 1992. 11:89-101

» F.L.H. Gielen, R.N. Friedman, and J.P. Wikswo, Jr "In Vivo Magnetic and Electric Recordings from Nerve Bundles and Single Motor Units in Mammalian Skeletal Muscle: Correlations with Muscle Force" J. Gen. Physiol. 1991. 98:1043-1061

» Y.P. Ma and J.P. Wikswo, Jr "Magnetic Shield for Wide-Bandwidth Magnetic Measurements for Nondestructive Testing and Biomagnetism" Rev. Sci. Instr. 1991. 62:2654-2661

» J.P. Barach and J.P. Wikswo, Jr "The Effect of Action Potential Propagation on a Numerical Simulation of a Cardiac Fiber Subjected to Secondary External Stimulus" Comp. & Biomed. Res. 1991. 24:435-452

» J.P. Wikswo, Jr., W. Altemeier, J.R. Balser, H.A. Kopelman, T. Wisialowski, and D.M. Roden "Virtual Cathode Effects During Stimulation of Cardiac Muscle: Two-Dimensional In Vivo Measurements" Circ. Res. 1991. 68:513-530

» R.S. Wijesinghe and J.P. Wikswo, Jr "A Model for Compound Action Potentials and Currents in a Nerve Bundle II: A Sensitivity Analysis of Model Parameters for the Forward and Inverse Calculations" Annals of Biomed. Eng. 1991. 19:73-96

» D.J. Staton, Y.P. Ma, N.G. Sepulveda, and J.P. Wikswo, Jr "High-Resolution Magnetic Mapping Using a SQUID Magnetometer Array" IEEE Trans. Mag. 1991. MAG-27:3237-3240

» R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr "A Model for Compound Action Potentials and Currents in a Nerve Bundle I: The Forward Calculation" Annals of Biomed. Eng. 1991. 19:43-72

» R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr "A Model for Compound Action Potentials and Currents in a Nerve Bundle III: A Comparison of the Conduction Velocity Distributions Calculated from Compound Action Currents and Potentials" Annals of Biomed. Eng. 1991. 19:97-121

» J.P. Wikswo, Jr. and J.M. vanEgeraat "Cellular Magnetic Fields: Fundamental and Applied Measurements on Nerve Axons, Peripheral Nerve Bundles, and Skeletal Muscle" J. Clin. Neurophysiology 1991. 8:170-188

» S. Tan, B.J. Roth, and J.P. Wikswo, Jr "The Magnetic Field of Cortical Current Sources: The Application of a Spatial Filtering Model to the Forward and Inverse Problem" Electroencep. and Clin. Neurophys. 1990. 76:73-85

» J.P. Wikswo, Jr "Biomagnetic Sources and Their Models" 1990. S.J. Williamson, M. Hoke, G. Stroink, and M. Kotani, Eds., :pp. 1-18

» J.M. van Egeraat, R.N. Friedman, and J.P. Wikswo, Jr "Magnetic Field of a Single Muscle Fiber: First Measurements and a Core Conductor Model" Biophys. J. 1990. 57:663-667

» N.G. Sepulveda, J.P. Wikswo, Jr., and D.S. Echt "Finite Element Analysis of Cardiac Defibrillation Current Distributions" IEEE Trans. Biomed. Eng. 1990. 37:354-365

» B.J. Roth and J.P. Wikswo, Jr "Apodized Pickup Coils for Improved Spatial Resolution of SQUID Magnetometers" Rev. Sci. Instr. 1990. 61:2439-2448

» B.J. Roth and J.P. Wikswo, Jr "Longitudinal Resistance in Cardiac Muscle and its Effects on Propagation" Cell Interactions and Gap Junctions 1989. N. Sperelakis and W.C. Cole, Eds., :pp. 165-178

» N.G. Sepulveda, B.J. Roth, and J.P. Wikswo, Jr "Current Injection into a Two-Dimensional Anisotropic Bidomain" Biophys. J. 1989. 55:987-999

» B.J. Roth, N.G. Sepulveda, and J.P. Wikswo, Jr "Using a Magnetometer to Image a Two-dimensional Current Distribution" J. Appl. Phys. 1989. 65:361-372

» J.P. Wikswo, Jr "A Review of Intermediate Physics for Medicine and Biology by R.K. Hobbie" Physics Today 1989. :75-76

» R. Maniewski, T. Katila, T. Poutanen, P. Siltanen, T. Varpula, and J.P. Wikswo, Jr "Magnetic Measurements of Cardiac Mechanical Activity" IEEE Trans. Biomed. Eng 1988. 35:662-670

» B.J. Roth, W.-Q. Guo, and J.P. Wikswo, Jr "The Effects of Spiral Anisotropy on the Electric Potential and the Magnetic Field at the Apex of the Heart" Mathematical Biosciences 1988. 88:191-221

» J.P. Wikswo, Jr. and B.J. Roth "Magnetic Determination of the Spatial Extent of a Single Cortical Current Source: A Theoretical Analysis" Electroenceph. and Clin. Neurophys. 1988. 69:266-276

» B.J. Roth, F.L.H. Gielen, and J.P. Wikswo, Jr "Spatial and Temporal Frequency-Dependent Conductivities in Volume Conduction Calculations of Skeletal Muscle" Mathematical Biosciences 1988. 88:159-189

» N.G. Sepulveda and J.P. Wikswo, Jr "Electric and Magnetic Fields from Two-Dimensional Anisotropic Bisyncytia" Biophys. J. 1987. 51:557-568

» J.P. Barach and J.P. Wikswo, Jr "Computer Simulation of Action Potential Propagation in Septated Nerve Fibers" Biophys. J. 1987. 51:177-183

» A.K. Bajaj, H.A. Kopelman, J.P. Wikswo, Jr., F. Cassidy, R.L. Woosley, and D.M. Roden "Frequency- and Orientation-Dependent Effects of Mexiletine and Quinidine on Conduction in the Intact Dog Heart" Circulation 1987. 75:1065-1073

» V.R. Hentz, J.P. Wikswo, Jr., and G.S. Abraham "Magnetic Measurements of Nerve Action Current: A New Intraoperative Technique" Peripheral Nerve Repair and Regeneration 1986. 1:27-36

» B.J. Roth and J.P. Wikswo, Jr "Electrically-Silent Magnetic Fields" Biophys. J. 1986. 50:739-745

» F.L.H. Gielen, B.J. Roth, and J.P. Wikswo, Jr "Capabilities of a Toroid-Amplifier System for Magnetic Measurement of Current in Biological Tissue" IEEE Trans. Biomed. Eng. 1986. BME-33:910-921

» B.J. Roth and J.P. Wikswo, Jr "A Bi-Domain Model for the Extracellular Potential and Magnetic Field of Cardiac Tissue" IEEE Trans. Biomed. Eng 1986. BME-33:467-469

» M.C. Leifer, J.P. Wikswo, Jr., J. Griffin, W.M. Barry, and D.C. Harrison "The Effects of the Heart-Lung Boundary on the Magnetocardiogram" J. Electrocard. 1986. 19:23-32

» B.J. Roth and J.P. Wikswo, Jr "The Electrical Potential and the Magnetic Field of an Axon in a Nerve Bundle" Mathematical Biosciences 1985. 76:37-57

» J.E. Barnhill, J.P. Wikswo, Jr., A.K. Dawson, S. Gundersen, R.M.S. Robertson, D. Robertson, R. Virmani, and R.F. Smith "The QRS Complex During Transient Myocardial Ischemia: Studies in Patients with Variant Angina Pectoris and in a Canine Preparation" Circulation 1985. 71:901-911

» J.P. Barach, B.J. Roth, and J.P. Wikswo, Jr "Magnetic Measurement of Action Currents in a Single Nerve Axon: A Core Conductor Model" IEEE Trans. Biomed. Eng. 1985. BME-32:136-140

» J.P. Wikswo, Jr. and K.R. Swinney "Scalar Multipole Expansions and Their Dipole Equivalents" J. Appl. Phys. 1985. 57:4301-4308

» B.J. Roth and J.P. Wikswo, Jr "The Magnetic Field of a Single Axon: A Comparison of Theory and Experiment" Biophys. J. 1985. 48:93-109

» D.P. Russell and J.P. Wikswo, Jr "Optimisation of State Selection and Focusing of a Neutral Atomic Hydrogen Beam by a Hexapole Magnet" J. Physics 1985. 18:933-940

» J.K. Woosley, B.J. Roth, and J.P. Wikswo, Jr "The Magnetic Field of a Single Nerve Axon: A Volume Conductor Model" Mathematical Biosciences 1985. 76:1-36

» J.A. Freeman, P.B. Manis, G.J. Snipes, B.N. Mayes, P.C. Samson, J.P. Wikswo, Jr., and D.B. Freeman "Steady Growth Cone Currents Revealed by a Novel Circularly Vibrating Probe: A Possible Mechanism Underlying Neurite Growth" In: Biology of the Nerve Growth Cone. S.B. Kater and P. Letourneau, Eds., J. Neuroscience Res. 1985. (Special Monongraph), pp. 26-38 (1984):and J. Neuroscience Res., 13: 257-283

» J.P. Wikswo, Jr. and K.R. Swinney "A Comparison of Scalar Multipole Expansions" J. Appl. Phys. 1984. 56:3039-3049

» R.F. Smith, J.E. Barnhill, and J.P. Wikswo, Jr "Early Use of Timolol in Acute Myocardial Infarction" N. England J. Med. 1984. 310:1667

» J.P. Wikswo, Jr., P.C. Samson, and R.P. Giffard "A Low-Noise, Low Input Impedance Amplifier for Magnetic Measurements of Nerve Action Currents" IEEE Trans. Biomed. Eng. 1983. BME-30:215-221

» M.C. Leifer and J.P. Wikswo, Jr "Optimization of a SQUID Clip-On Current Probe" Rev. Sci. Instr. 1983. 54:1017-1022

» J.P. Wikswo, Jr "Cellular Action Currents" In: Biomagnetism, An Interdisciplinary Approach 1983. S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds., :pp. 173-207

» J.P. Wikswo, Jr "Theoretical Aspects of the ECG-MCG Relationship" In: Biomagnetism, An Interdisciplinary Approach 1983. S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds., :pp. 311-326

» J.P. Wikswo, Jr. and J.P. Barach "Possible Sources of New Information in the Magnetocardiogram" J. Theoretical Biol. 1982. 95:721-729

» J.P. Wikswo, Jr "Improved Instrumentation for Measuring the Magnetic Field of Cellular Action Currents" Rev. Sci. Instr. 1982. 53:1846-1850

» J.P. Wikswo, Jr., S.C. Gundersen, W. Murphy, A.K. Dawson, and R.F. Smith "Sequential QRS Vector Subtractions in Acute Myocardial Infarction in Humans" Circ. Res. 1981. 49:1055-1062

» L.J. Schaad, B.A. Hess, J.P. Wikswo, Jr., and W.M. Fairbank "Quark Chemistry" Phys. Rev. A 1981. 23:1600-1607

» J.P. Wikswo, Jr "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Theory" Medical Physics 1980. 7:297-306

» K.R. Swinney and J.P. Wikswo, Jr "A Calculation of the Magnetic Field of a Nerve Action Potential" Biophys. J. 1980. 32:719-732

» J.P. Barach, J.A. Freeman and J.P. Wikswo, Jr "Experiments on the Magnetic Field of Nerve Action Potentials" J. Appl. Phys. 1980. 51:4532-4538

» J.P. Wikswo, Jr. and J.P. Barach "An Estimate of the Steady Magnetic Field Strength Required to Influence Nerve Conduction" IEEE Trans. Biomed. Eng. 1980. BME-27:722-723

» J.P. Wikswo, Jr., J.E. Opfer, and W.M. Fairbank "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Experiment" Medical Physics 1980. 7:307-314

» J.P. Wikswo, Jr., J.P. Barach, and J.A. Freeman "Magnetic Field of a Nerve Impulse: First Measurements" Science 1980. 208:53-55

» J.P. Wikswo, Jr., J.A.V. Malmivuo, W.H. Barry, M.C. Leifer, and W.M. Fairbank "Theory and Application of Magnetocardiography" In: Cardiovascular Physics 1979. D.N. Ghista, E. Van Vollenhoven, and W. Yang, Eds., :pp. 1-67

» J.P. Wikswo, Jr "The Calculation of the Magnetic Field from a Current Distribution: Application to Finite Element Techniques" IEEE Trans. Mag. 1978. MAG-14:1076-1077

» J.A.V. Malmivuo and J.P. Wikswo, Jr "A New Practical Lead System for Vector Magnetocardiography" Proc. IEEE 1977. 65:809-811

» J.A.V. Malmivuo, J.P. Wikswo, Jr., W.H. Barry, D.C. Harrison, and W.M. Fairbank "Consistent System of Rectangular and Spherical Co-ordinates for Electrocardiography and Magnetocardiography" Med. Biol. Eng. and Comput. 1977. 15:413-415

» W.H. Barry, D.C. Harrison, W.M. Fairbank, K. Lehrman, J.A.V. Malmivuo, and J.P. Wikswo, Jr "Measurement of the Human Magnetic Heart Vector" Science 1977. 198:1159-1162

» R.D. Sandell, J.P. Wikswo, Jr., J.M. Pickler, and B.S. Deaver, Jr "Quantized Fluctuations in the Josephson Oscillations of a Shunted Superconducting Point Contact" J. Appl. Phys. 1973. 44:3312-3318