Center for Matrix Biology - Vanderbilt University and Medical Center

Eric G. Neilson, M.D.
Professor in the Department of Medicine
Hugh J Morgan Professor of Medicine & Cell Biology
Chair and Professor in Department of Medicine

	Office Address:	D-3100 MCN
	Mailing Address:	D-3100 MCN Nashville, TN 2358
	Lab address:	D-3100 MCN
	Phone:	2-3146
		email

Secondary appointment in the Cell and Developmental Biology department.

Research Summary

The principal goal of my research is to understand the nephritogenic immune response in autoimmune renal disease. This research runs the gamut of immunologic mechanisms to understanding the development or organ fibrogenesis and cellular transdifferentiation.

Our studies critically analyze the immunogenetic and interactional events surrounding T cell activation, effector T cell differentiation, immune modulation of renal tubular cells and fibroblasts in anti-basement membrane diseases, and with this understanding, develop experimental strategies which can attenuate the expression of renal injury. We have a particularly active interest in the cell fate of fibroblasts during fibrogenesis in transgenic mice.

More recently we have gotten interested in how breast cancer cells use the same programs when they metastasize.

We use trangenic and knockin mice, cell sorting, biochemical methosds of protein identification, molecular cloning and mutagenesis, as well as cell culture and confocal microscopy.

Research Keywords

Gene therapy, Genetics, Immunology, Knockout, Molecular medicine, Renal biology,

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Associated initiative(s):

Fibrosis

Career opportunities:
Postdoctoral Position Available

Selected Publications

» Venkov, CD, Link, AJ, Jennings, JL, Plieth, D, Inoue, T, Nagai, K, Xu, C, Dimitrova, YN, Rauscher, FJ, Neilson, EG A proximal activator of transcription in epithelial-mesenchymal transition J Clin Invest 2007. 117:482-91

» Harris, RC, Neilson, EG Toward a unified theory of renal progression Annu Rev Med 2006. 57:365-80

» Neilson, EG Mechanisms of disease: Fibroblasts--a new look at an old problem Nat Clin Pract Nephrol 2006. 2:101-8

» Chen, J, Chen, JK, Neilson, EG, Harris, RC Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy J Am Soc Nephrol 2006. 17:1615-23

» Rosenbloom, ST, Chiu, KW, Byrne, DW, Talbert, DA, Neilson, EG, Miller, RA Interventions to Regulate Ordering of Serum Magnesium Levels: an unintended consequence of decision support J Am Med Inform Assoc 2005. :

» Borza, DB, Bondar, O, Colon, S, Todd, P, Sado, Y, Neilson, EG, Hudson, BG Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: Novel mechanisms for immune privilege and autoimmune pathogenesis J Biol Chem 2005. :

» Neilson, EG Setting a trap for tissue fibrosis Nat Med 2005. 11:373-4

» Chen, JK, Chen, J, Neilson, EG, Harris, RC Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy J Am Soc Nephrol 2005. 16:1384-91

» Inoue, T, Plieth, D, Venkov, CD, Xu, C, Neilson, EG Antibodies against macrophages that overlap in specificity with fibroblasts Kidney Int 2005. 67:2488-93

» Cheng, N, Bhowmick, NA, Chytil, A, Gorksa, AE, Brown, KA, Muraoka, R, Arteaga, CL, Neilson, EG, Hayward, SW, Moses, HL Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks Oncogene 2005. :

» Rossini, M, Cheunsuchon, B, Donnert, E, Ma, LJ, Thomas, JW, Neilson, EG, Fogo, AB Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease Kidney Int 2005. 68:2621-8

» Iwano, Masayuki, Neilson, Eric G Mechanisms of tubulointerstitial fibrosis Curr Opin Nephrol Hypertens 2004. 13:279-84

» Bhowmick, Neil A, Chytil, Anna, Plieth, David, Gorska, Agnieszka E, Dumont, Nancy, Shappell, Scott, Washington, M Kay, Neilson, Eric G, Moses, Harold L TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia Science 2004. 303:848-51

» Lawson, William E, Polosukhin, Vasiliy V, Zoia, Ornella, Stathopoulos, Georgios T, Han, Wei, Plieth, David, Loyd, James E, Neilson, Eric G, Blackwell, Timothy S Characterization of Fibroblast Specific Protein 1 in Pulmonary Fibrosis Am J Respir Crit Care Med 2004. :

» Bhowmick, Neil A, Neilson, Eric G, Moses, Harold L Stromal fibroblasts in cancer initiation and progression Nature 2004. 432:332-7

» Neilson, Eric G, Johnson, Kevin B, Rosenbloom, S Trent, Dupont, William D, Talbert, Doug, Giuse, Dario A, Kaiser, Allen, Miller, Randolph A, , The impact of peer management on test-ordering behavior Ann Intern Med 2004. 141:196-204

» Peng, M, Jarett, L, Meade, R, Madaio, MP, Hancock, WW, George, AL, Neilson, EG, Gasser, DL Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice Kidney Int 2004. 66:20-8

» Neilson, Eric G, Plieth, David, Venkov, Christo Epithelial-mesenchymal transitions and the intersecting cell fate of fibroblasts and metastatic cancer cells Trans Am Clin Climatol Assoc 2003. 114:87-100; discussion 100-1

» Hudson, Billy G, Tryggvason, Karl, Sundaramoorthy, Munirathinam, Neilson, Eric G Alport''s syndrome, Goodpasture''s syndrome, and type IV collagen N Engl J Med 2003. 348:2543-56

» Tarquinio, Gregg T, Dittus, Robert S, Byrne, Daniel W, Kaiser, Allen, Neilson, Eric G Effects of performance-based compensation and faculty track on the clinical activity, research portfolio, and teaching mission of a large academic department of medicine Acad Med 2003. 78:690-701

» Okada, Hirokazu, Inoue, Tsutomu, Kanno, Yoshihiko, Kobayashi, Tatsuya, Watanabe, Yusuke, Ban, Shinichi, Neilson, Eric G, Suzuki, Hiromichi Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome Kidney Int 2003. 64:1722-32

» Neilson, Eric G The role of medical school admissions committees in the decline of physician-scientists J Clin Invest 2003. 111:765-7

» Strutz, Frank, Neilson, Eric G New insights into mechanisms of fibrosis in immune renal injury Springer Semin Immunopathol 2003. 24:459-76

» Xue, Chengsen, Plieth, David, Venkov, Christo, Xu, Carol, Neilson, Eric G The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis Cancer Res 2003. 63:3386-94

» Kalluri, Raghu, Neilson, Eric G Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 2003. 112:1776-84

» Borza, Dorin-Bogdan, Neilson, Eric G, Hudson, Billy G Pathogenesis of Goodpasture syndrome: a molecular perspective Semin Nephrol 2003. 23:522-31

» Zeisberg, Michael, Ericksen, Mark B, Hamano, Yuki, Neilson, Eric G, Ziyadeh, Fuad, Kalluri, Raghu Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells Biochem Biophys Res Commun 2002. 295:401-7

» Meyers, Kevin E C, Allen, Juanita, Gehret, Jeffrey, Jacobovits, Aya, Gallo, Michael, Neilson, Eric G, Hopfer, Helmut, Kalluri, Raghu, Madaio, Michael P Human antiglomerular basement membrane autoantibody disease in XenoMouse II Kidney Int 2002. 61:1666-73

» Makino, Yasuhiko, Cook, Donald N, Smithies, Oliver, Hwang, Olivia Y, Neilson, Eric G, Turka, Laurence A, Sato, Hiroshi, Wells, Andrew D, Danoff, Theodore M Impaired T cell function in RANTES-deficient mice Clin Immunol 2002. 102:302-9

» Strutz, Frank, Zeisberg, Michael, Ziyadeh, Fuad N, Yang, Chang-Qing, Kalluri, Raghu, M??ller, Gerhard A, Neilson, Eric G Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation Kidney Int 2002. 61:1714-28

» Iwano, Masayuki, Plieth, David, Danoff, Theodore M, Xue, Chengsen, Okada, Hirokazu, Neilson, Eric G Evidence that fibroblasts derive from epithelium during tissue fibrosis J Clin Invest 2002. 110:341-50

» LiliA?, Mirjana, Santori, Fabio R, Neilson, Eric G, Frey, Alan B, VukmanoviA?, Stanislav The role of fibroblasts in thymocyte-positive selection J Immunol 2002. 169:4945-50

» Iwano, M, Fischer, A, Okada, H, Plieth, D, Xue, C, Danoff, T M, Neilson, E G Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts Mol Ther 2001. 3:149-59

» Aronoff, D M, Neilson, E G Antipyretics: mechanisms of action and clinical use in fever suppression Am J Med 2001. 111:304-15

» Kalluri, R, Torre, A, Shield, C F, Zamborsky, E D, Werner, M C, Suchin, E, Wolf, G, Helmchen, U M, van den Heuvel, L P, Grossman, R, Aradhye, S, Neilson, E G Identification of alpha3, alpha4, and alpha5 chains of type IV collagen as alloantigens for Alport posttransplant anti-glomerular basement membrane antibodies Transplantation 2000. 69:679-83

» Furst, H, Hallows, K R, Post, J, Chen, S, Kotzker, W, Goldfarb, S, Ziyadeh, F N, Neilson, E G The urine/plasma electrolyte ratio: a predictive guide to water restriction Am J Med Sci 2000. 319:240-4

» Okada, H, Inoue, T, Suzuki, H, Strutz, F, Neilson, E G Epithelial-mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo Nephrol Dial Transplant 2000. 15 Suppl 6:44-6

» Dell, K M, Li, Y X, Peng, M, Neilson, E G, Gasser, D L Localization of the mouse kidney disease (kd) gene to a YAC/BAC contig on Chromosome 10 Mamm Genome 2000. 11:967-71

» Costa, S T, Ausiello, D, Joiner, K, Neilson, E G, Taylor, I, Wenzel, R Supporting research in departments of internal medicine: recommendations for NIH Am J Med 2000. 109:178-80

» Okada, H, Ban, S, Nagao, S, Takahashi, H, Suzuki, H, Neilson, E G Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation Kidney Int 2000. 58:587-97

» George, A L, Neilson, E G Genetics of kidney disease Am J Kidney Dis 2000. 35:S160-9

» Kalluri, R, Cantley, L G, Kerjaschki, D, Neilson, E G Reactive oxygen species expose cryptic epitopes associated with autoimmune goodpasture syndrome J Biol Chem 2000. 275:20027-32

» Ortiz, A, Lorz, C, Catal?!n, M P, Danoff, T M, Yamasaki, Y, Egido, J, Neilson, E G Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure Kidney Int 2000. 57:969-81

» Wolf, G, Kalluri, R, Ziyadeh, F N, Neilson, E G, Stahl, R A Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells Proc Assoc Am Physicians 1999. 111:357-64

» Neilson, E G Interstitial nephritis: another kissing disease J Clin Invest 1999. 104:1671-2

» Meyers, K E, Kinniry, P A, Kalluri, R, Neilson, E G, Madaio, M P Human Goodpasture anti-alpha3(IV)NC1 autoantibodies share structural determinants Kidney Int 1998. 53:402-7

» Wolf, G, Neilson, E G Morphogenic cues that modulate podocyte growth Kidney Int 1998. 53:1087-8

» Okada, H, Danoff, T M, Fischer, A, Lopez-Guisa, J M, Strutz, F, Neilson, E G Identification of a novel cis-acting element for fibroblast-specific transcription of the FSP1 gene Am J Physiol 1998. 275:F306-14

» Yee, J, Kuncio, G S, Bhandari, B, Shihab, F S, Neilson, E G Identification of promoter activity and differential expression of transcripts encoding the murine stromelysin-1 gene in renal cells Kidney Int 1997. 52:120-9

» Kalluri, R, Shield, C F, Todd, P, Hudson, B G, Neilson, E G Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis J Clin Invest 1997. 99:2470-8

» Neilson, E G, Hull, A R, Wish, J B, Neylan, J F, Sherman, D, Suki, W N The Ad Hoc Committee report on estimating the future workforce and training requirements for nephrology. The Ad Hoc Committee on Nephrology Manpower Needs J Am Soc Nephrol 1997. 8:S1-4

» Kalluri, R, Meyers, K, Mogyorosi, A, Madaio, M P, Neilson, E G Goodpasture syndrome involving overlap with Wegener''s granulomatosis and anti-glomerular basement membrane disease J Am Soc Nephrol 1997. 8:1795-800

» Okada, H, Danoff, T M, Kalluri, R, Neilson, E G Early role of Fsp1 in epithelial-mesenchymal transformation Am J Physiol 1997. 273:F563-74

» Kalluri, R, Danoff, T M, Okada, H, Neilson, E G Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice J Clin Invest 1997. 100:2263-75

» Danoff, T M, Chiang, M, J??nne, P A, Neilson, E G Screening for homologous recombination in ES cells using RT-PCR Biotechniques 1997. 22:22-4, 26

» Ortiz, A, Ziyadeh, F N, Neilson, E G Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys J Investig Med 1997. 45:50-6

» Mange, K, Matsuura, D, Cizman, B, Soto, H, Ziyadeh, F N, Goldfarb, S, Neilson, E G Language guiding therapy: the case of dehydration versus volume depletion Ann Intern Med 1997. 127:848-53

» Kalluri, R, Melendez, E, Rumpf, K W, Sattler, K, M??ller, G A, Strutz, F, Neilson, E G Specificity of circulating and tissue-bound autoantibodies in Goodpasture syndrome Proc Assoc Am Physicians 1996. 108:134-9

» Wolf, G, Neilson, E G From converting enzyme inhibition to angiotensin II receptor blockade: new insight on angiotensin II receptor subtypes in the kidney Exp Nephrol 1996. 4 Suppl 1:8-19

» Okada, H, Strutz, F, Danoff, T M, Kalluri, R, Neilson, E G Possible mechanisms of renal fibrosis Contrib Nephrol 1996. 118:147-54

» Kalluri, R, Sun, M J, Hudson, B G, Neilson, E G The Goodpasture autoantigen. Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen J Biol Chem 1996. 271:9062-8

» Neilson, E G When does a generalist need a specialist J Gen Intern Med 1996. 11:247-8

» Kuncio, G S, Alvarez, R, Li, S, Killen, P D, Neilson, E G Transforming growth factor-beta modulation of the alpha 1(IV) collagen gene in murine proximal tubular cells Am J Physiol 1996. 271:F120-5

» Okada, H, Strutz, F, Danoff, T M, Neilson, E G Possible pathogenesis of renal fibrosis Kidney Int Suppl 1996. 54:S37-8

» Heeger, P S, Smoyer, W E, Jones, M, Hopfer, S, Neilson, E G Heterogeneous T cell receptor V beta gene repertoire in murine interstitial nephritis Kidney Int 1996. 49:1222-30

» Merkel, F, Kalluri, R, Marx, M, Enders, U, Stevanovic, S, Giegerich, G, Neilson, E G, Rammensee, H G, Hudson, B G, Weber, M Autoreactive T-cells in Goodpasture''s syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen Kidney Int 1996. 49:1127-33

» Gonz?!lez-Cuadrado, S, L??pez-Armada, M J, G??mez-Guerrero, C, Subir?!, D, Garcia-Sahuquillo, A, Ortiz-Gonzalez, A, Neilson, E G, Egido, J, Ortiz, A Anti-Fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells Kidney Int 1996. 49:1064-70

» Kalluri, R, Petrides, S, Wilson, C B, Tomaszewski, J E, Palevsky, H I, Grippi, M A, Madaio, M P, Neilson, E G Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome Ann Intern Med 1996. 124:651-3

» Ortiz-Arduan, A, Danoff, T M, Kalluri, R, Gonz?!lez-Cuadrado, S, Karp, S L, Elkon, K, Egido, J, Neilson, E G Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia Am J Physiol 1996. 271:F1193-201

» Friedman, J R, Fredericks, W J, Jensen, D E, Speicher, D W, Huang, X P, Neilson, E G, Rauscher, F J KAP-1, a novel corepressor for the highly conserved KRAB repression domain Genes Dev 1996. 10:2067-78

» Strutz, F, M??ller, G A, Neilson, E G Transdifferentiation: a new angle on renal fibrosis Exp Nephrol 1996. 4:267-70

» Wolf, G, Neilson, E G Cellular biology of tubulointerstitial growth Curr Top Pathol 1995. 88:69-97

» Kalluri, R, Wilson, C B, Weber, M, Gunwar, S, Chonko, A M, Neilson, E G, Hudson, B G Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome J Am Soc Nephrol 1995. 6:1178-85

» Neilson, E G, Ausiello, D, Demer, L L Physician-scientists as missing persons. Association of Subspecialty Professors J Investig Med 1995. 43:534-42

» Peissel, B, Geng, L, Kalluri, R, Kashtan, C, Rennke, H G, Gallo, G R, Yoshioka, K, Sun, M J, Hudson, B G, Neilson, E G Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients J Clin Invest 1995. 96:1948-57

» Kalluri, R, van den Heuvel, L P, Smeets, H J, Schroder, C H, Lemmink, H H, Boutaud, A, Neilson, E G, Hudson, B G A COL4A3 gene mutation and post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome Kidney Int 1995. 47:1199-204

» Strutz, F, Okada, H, Lo, C W, Danoff, T, Carone, R L, Tomaszewski, J E, Neilson, E G Identification and characterization of a fibroblast marker: FSP1 J Cell Biol 1995. 130:393-405

» Neilson, E G Subspecialty work force issues Ann Intern Med 1995. 122:804

» Kashgarian, M, Neilson, E G Death is part of life Curr Opin Nephrol Hypertens 1995. 4:251-2

» Ziyadeh, F N, Fumo, P, Rodenberger, C H, Kuncio, G S, Neilson, E G Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen alpha 1 (IV) in glomerular mesangial cells J Diabetes Complications 1995. 9:255-61

» Heeger, P S, Smoyer, W E, Saad, T, Albert, S, Kelly, C J, Neilson, E G Molecular analysis of the helper T cell response in murine interstitial nephritis. T cells recognizing an immunodominant epitope use multiple T cell receptor V beta genes with similarities across CDR3 J Clin Invest 1994. 94:2084-92

» Danoff, T M, Lalley, P A, Chang, Y S, Heeger, P S, Neilson, E G Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES J Immunol 1994. 152:1182-9

» Heeger, P S, Neilson, E G Overcoming tolerance in autoimmune renal disease Curr Opin Nephrol Hypertens 1994. 3:123-32

» Kalluri, R, Weber, M, Netzer, K O, Sun, M J, Neilson, E G, Hudson, B G COL4A5 gene deletion and production of post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome Kidney Int 1994. 45:721-6

» Kashgarian, M, Neilson, E G Cycling around kidney disease from birth to death Curr Opin Nephrol Hypertens 1994. 3:305-7

» Karp, S L, Ortiz-Arduan, A, Li, S, Neilson, E G Epithelial differentiation of metanephric mesenchymal cells after stimulation with hepatocyte growth factor or embryonic spinal cord Proc Natl Acad Sci U S A 1994. 91:5286-90

» Wolf, G, Neilson, E G Isoproterenol induces mitogenesis in MCT and LLC-PK1 tubular cells J Am Soc Nephrol 1994. 4:1995-2002

» Strutz, F, Neilson, E G The role of lymphocytes in the progression of interstitial disease Kidney Int Suppl 1994. 45:S106-10

» Ding, J, Kashtan, C E, Fan, W W, Kleppel, M M, Sun, M J, Kalluri, R, Neilson, E G, Michael, A F A monoclonal antibody marker for Alport syndrome identifies the Alport antigen as the alpha 5 chain of type IV collagen Kidney Int 1994. 45:1504-6

» Albert, S E, Strutz, F, Shelton, K, Haverty, T, Sun, M J, Li, S R, Denham, A, Maki, R A, Neilson, E G Characterization of a cis-acting regulatory element which silences expression of the class II-A beta gene in epithelium J Exp Med 1994. 180:233-40

» Neilson, E G Is immunologic tolerance of self modulated through antigen presentation by parenchymal epithelium Kidney Int 1993. 44:927-31

» Yee, J, Neilson, E G Immune modulation of biologic systems in renal somatic cells Kidney Int 1993. 43:128-34

» Myers, J C, Sun, M J, D''Ippolito, J A, Jabs, E W, Neilson, E G, Dion, A S Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain Gene 1993. 123:211-7

» Wolf, G, Neilson, E G Angiotensin II as a renal growth factor J Am Soc Nephrol 1993. 3:1531-40

» Karp, S L, Kieber-Emmons, T, Sun, M J, Wolf, G, Neilson, E G Molecular structure of a cross-reactive idiotype on autoantibodies recognizing parenchymal self J Immunol 1993. 150:867-79

» Wolf, G, Aberle, S, Thaiss, F, Nelson, P J, Krensky, A M, Neilson, E G, Stahl, R A TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells Kidney Int 1993. 44:795-804

» Neilson, E G, Kalluri, R, Sun, M J, Gunwar, S, Danoff, T, Mariyama, M, Myers, J C, Reeders, S T, Hudson, B G Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen J Biol Chem 1993. 268:8402-5

» Veerapen, K, Schumacher, H R, van Linthoudt, D, Neilson, E G, Wang, F Tophaceous gout in young patients with systemic lupus erythematosus J Rheumatol 1993. 20:721-4

» Wolf, G, Neilson, E G Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells Kidney Int Suppl 1993. 39:S100-7

» Neilson, E G The nephritogenic T lymphocyte response in interstitial nephritis Semin Nephrol 1993. 13:496-502

» Alvarez, R J, Sun, M J, Haverty, T P, Iozzo, R V, Myers, J C, Neilson, E G Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines Kidney Int 1992. 41:14-23

» Shiraga, H, Min, W, VanDusen, W J, Clayman, M D, Miner, D, Terrell, C H, Sherbotie, J R, Foreman, J W, Przysiecki, C, Neilson, E G Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily Proc Natl Acad Sci U S A 1992. 89:426-30

» Wolf, G, Haberstroh, U, Neilson, E G Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells Am J Pathol 1992. 140:95-107

» Wolf, G, Neilson, E G Increases in levels of collagen types I and IV messenger ribonucleic acid in murine kidneys after treatment with ciclosporin Nephron 1992. 60:87-91

» Heeger, P, Wolf, G, Meyers, C, Sun, M J, O''Farrell, S C, Krensky, A M, Neilson, E G Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes Kidney Int 1992. 41:220-5

» Haverty, T P, Kelly, C J, Hoyer, J R, Alvarez, R, Neilson, E G Tubular antigen-binding proteins repress transcription of type IV collagen in the autoimmune target epithelium of experimental interstitial nephritis J Clin Invest 1992. 89:517-23

» Rocco, M V, Neilson, E G, Hoyer, J R, Ziyadeh, F N Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease Am J Physiol 1992. 262:F679-86

» Levey, A S, Lan, S P, Corwin, H L, Kasinath, B S, Lachin, J, Neilson, E G, Hunsicker, L G, Lewis, E J Progression and remission of renal disease in the Lupus Nephritis Collaborative Study. Results of treatment with prednisone and short-term oral cyclophosphamide Ann Intern Med 1992. 116:114-23

» Furmanski, P, Neilson, E G, Bhorjee, J S The role of cytokines in the regulation of cell function and in the pathogenesis of disease: a Pathology A/Pathology B Study Section Workshop. Working report from the Division of Research Grants, National Institutes of Health Cancer Res 1992. 52:6129-33

» Wolf, G, Neilson, E G Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene Am J Physiol 1992. 263:F931-8

» Wolf, G, Kuncio, G S, Sun, M J, Neilson, E G Expression of homeobox genes in a proximal tubular cell line derived from adult mice Kidney Int 1991. 39:1027-33

» Yee, J, Kuncio, G S, Neilson, E G Tubulointerstitial injury following glomerulonephritis Semin Nephrol 1991. 11:361-6

» Albert, S E, Shelton, K, Sun, M J, Neilson, E G Analysis of the cDNA sequence encoding MHC-A beta in tubular epithelium from mouse kidney Kidney Int 1991. 40:139-42

» Kuncio, G S, Neilson, E G, Haverty, T Mechanisms of tubulointerstitial fibrosis Kidney Int 1991. 39:550-6

» Wolf, G, Neilson, E G Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia Kidney Int 1991. 39:401-20

» Wolf, G, Killen, P D, Neilson, E G Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells Cell Regul 1991. 2:219-27

» Wolf, G, Neilson, E G, Goldfarb, S, Ziyadeh, F N The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture Biochem Biophys Res Commun 1991. 176:902-9

» Karp, S L, Albert, S E, Neilson, E G The nephritogenic immune response Curr Opin Immunol 1991. 3:906-11

» Neilson, E G, Sun, M J, Kelly, C J, Hines, W H, Haverty, T P, Clayman, M D, Cooke, N E Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease Proc Natl Acad Sci U S A 1991. 88:2006-10

» Wolf, G, Killen, P D, Neilson, E G Cyclosporin A stimulates transcription and procollagen secretion in tubulointerstitial fibroblasts and proximal tubular cells J Am Soc Nephrol 1990. 1:918-22

» Hines, W H, Mann, R A, Kelly, C J, Neilson, E G Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine J Immunol 1990. 144:75-83

» Wolf, G, Neilson, E G Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells Am J Physiol 1990. 259:F768-77

» Haverty, T P, Watanabe, M, Neilson, E G, Kelly, C J Protective modulation of class II MHC gene expression in tubular epithelium by target antigen-specific antibodies. Cell-surface directed down-regulation of transcription can influence susceptibility to murine tubulointerstitial nephritis J Immunol 1989. 143:1133-41

» Neilson, E G Pathogenesis and therapy of interstitial nephritis Kidney Int 1989. 35:1257-70

» Hines, W H, Haverty, T P, Elias, J A, Neilson, E G, Kelly, C J T cell recognition of epithelial self Autoimmunity 1989. 5:37-47

» Guery, J C, Hedrich, H J, Mercier, P, Reetz, I C, Mandet, C, Mahieu, P, Neilson, E G, Druet, P Mapping of a gene for the Mr 48,000 tubular basement membrane antigen in the rat Immunogenetics 1989. 29:350-4

» Kelly, C J, Neilson, E G Contrasuppression in autoimmunity Immunol Res 1988. 7:56-66

» Shih, W Y, Clayman, M D, Kelly, C J, Hines, W, Neilson, E G Elution of kidney-bound antibody by pH-shift does not discriminate between antibodies differing in functional affinity for their ligand Int Arch Allergy Appl Immunol 1988. 87:327-33

» Clayman, M D, Sun, M J, Michaud, L, Brill-Dashoff, J, Riblet, R, Neilson, E G Clonotypic heterogeneity in experimental interstitial nephritis. Restricted specificity of the anti-tubular basement membrane B cell repertoire is associated with a disease-modifying crossreactive idiotype J Exp Med 1988. 167:1296-312

» Haverty, T P, Kelly, C J, Hines, W H, Amenta, P S, Watanabe, M, Harper, R A, Kefalides, N A, Neilson, E G Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis J Cell Biol 1988. 107:1359-68

» Shih, W, Hines, W H, Neilson, E G Effects of cyclosporin A on the development of immune-mediated interstitial nephritis Kidney Int 1988. 33:1113-8

» Haverty, T P, Neilson, E G Basement membrane gene expression in polycystic kidney disease Lab Invest 1988. 58:245-8

» Hines, W H, Mann, R A, Neilson, E G Murine interstitial nephritis. VIII. Characterization of Igh-V restriction determinants in the development of anti-idiotypic immunity using blocking antibodies J Autoimmun 1988. 1:143-57

» Kelly, C J, Mok, H, Neilson, E G The selection of effector T cell phenotype by contrasuppression modulates susceptibility to autoimmune injury J Immunol 1988. 141:3022-8

» Kelly, C J, Neilson, E G Medullary cystic disease: an inherited form of autoimmune interstitial nephritis Am J Kidney Dis 1987. 10:389-95

» Clayman, M D, Raymond, A, Colen, D, Moffitt, C, Wolf, C, Neilson, E G The Limulus amebocyte lysate assay. A rapid and sensitive method for diagnosing early gram-negative peritonitis in patients undergoing continuous ambulatory peritoneal dialysis Arch Intern Med 1987. 147:337-40

» Kelly, C J, Zurier, R B, Krakauer, K A, Blanchard, N, Neilson, E G Prostaglandin E1 inhibits effector T cell induction and tissue damage in experimental murine interstitial nephritis J Clin Invest 1987. 79:782-9

» Mann, R, Kelly, C J, Hines, W H, Clayman, M D, Blanchard, N, Sun, M J, Neilson, E G Effector T cell differentiation in experimental interstitial nephritis. I. The development and modulation of effector lymphocyte maturation by I-J+ regulatory T cells J Immunol 1987. 138:4200-8

» Neilson, E G, Kelly, C J, Clayman, M D, Hines, W H, Haverty, T, Sun, M J, Blanchard, N Murine interstitial nephritis. VII. Suppression of renal injury after treatment with soluble suppressor factor TsF1 J Immunol 1987. 139:1518-24

» Haverty, T, Haddad, J G, Neilson, E G 1,25-dihydroxyvitamin D3 stimulates interleukin-2 production by a T cell lymphoma line (MLA-144) cultured in vitamin D-deficient rat serum J Leukoc Biol 1987. 41:177-82

» Kelly, C J, Clayman, M D, Hines, W H, Neilson, E G Therapeutic immune regulation in experimental interstitial nephritis with suppressor T cells and their soluble factors Ciba Found Symp 1987. 129:73-87

» Kelly, C J, Neilson, E G Contrasuppression in autoimmunity. Abnormal contrasuppression facilitates expression of nephritogenic effector T cells and interstitial nephritis in kdkd mice J Exp Med 1987. 165:107-23

» Clayman, M D, Michaud, L, Neilson, E G Murine interstitial nephritis. VI. Characterization of the B cell response in anti-tubular basement membrane disease J Immunol 1987. 139:2242-9

» Kasinath, B S, Neilson, E G, Hebert, L, Schwartz, M M, Lewis, E J Short-term prognosis of severe proliferative lupus nephritis Am J Kidney Dis 1986. 8:239-43

» Clayman, M D, Michaud, L, Brentjens, J, Andres, G A, Kefalides, N A, Neilson, E G Isolation of the target antigen of human anti-tubular basement membrane antibody-associated interstitial nephritis J Clin Invest 1986. 77:1143-7

» Mann, R, Neilson, E G Murine interstitial nephritis. V. The auto-induction of antigen-specific Lyt-2+ suppressor T cells diminishes the expression of interstitial nephritis in mice with antitubular basement membrane disease J Immunol 1986. 136:908-12

» Kelly, C J, Clayman, M D, Neilson, E G Immunoregulation in experimental interstitial nephritis: immunization with renal tubular antigen in incomplete Freund''s adjuvant induces major histocompatibility complex-restricted, OX8+ suppressor T cells which are antigen-specific and inhibit the expression of disease J Immunol 1986. 136:903-7

» Kelly, C J, Korngold, R, Mann, R, Clayman, M, Haverty, T, Neilson, E G Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigen-specific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury J Immunol 1986. 136:526-31

» Goldstein, C S, Garrick, R E, Polin, R A, Gerdes, J S, Kolski, G B, Neilson, E G, Douglas, S D Fibronectin and complement secretion by monocytes and peritoneal macrophages in vitro from patients undergoing continuous ambulatory peritoneal dialysis J Leukoc Biol 1986. 39:457-64

» Ntoso, K A, Tomaszewski, J E, Jimenez, S A, Neilson, E G Penicillamine-induced rapidly progressive glomerulonephritis in patients with progressive systemic sclerosis: successful treatment of two patients and a review of the literature Am J Kidney Dis 1986. 8:159-63

» Neilson, E G, Clayman, M D, Haverty, T, Kelly, C J, Mann, R Experimental strategies for the study of cellular immunity in renal disease Kidney Int 1986. 30:264-79

» Agus, D, Mann, R, Clayman, M, Kelly, C, Michaud, L, Cohn, D, Neilson, E G The effects of daily cyclophosphamide administration on the development and extent of primary experimental interstitial nephritis in rats Kidney Int 1986. 29:635-40

» Neilson, E G, McCafferty, E, Mann, R, Michaud, L, Clayman, M Tubular antigen-derivatized cells induce a disease-protective, antigen-specific, and idiotype-specific suppressor T cell network restricted by I-J and Igh-V in mice with experimental interstitial nephritis J Exp Med 1985. 162:215-30

» Mann, R, Neilson, E G Pathogenesis and treatment of immune-mediated renal disease Med Clin North Am 1985. 69:715-50

» Kennedy, T L, Merrow, M, Phillips, S M, Norman, M, Neilson, E G Macrophage chemotaxis in anti-tubular basement membrane-induced interstitial nephritis in guinea pigs Clin Immunol Immunopathol 1985. 36:243-8

» Agus, D, Mann, R, Cohn, D, Michaud, L, Kelly, C, Clayman, M, Neilson, E G Inhibitory role of dietary protein restriction on the development and expression of immune-mediated antitubular basement membrane-induced tubulointerstitial nephritis in rats J Clin Invest 1985. 76:930-6

» Kelly, C J, Silvers, W K, Neilson, E G Tolerance to parenchymal self. Regulatory role of major histocompatibility complex-restricted, OX8+ suppressor T cells specific for autologous renal tubular antigen in experimental interstitial nephritis J Exp Med 1985. 162:1892-903

» Neilson, E G, McCafferty, E, Mann, R, Michaud, L, Clayman, M Murine interstitial nephritis. III. The selection of phenotypic (Lyt and L3T4) and idiotypic (RE-Id) T cell preferences by genes in Igh-1 and H-2K characterizes the cell-mediated potential for disease expression: susceptible mice provide a unique effector T cell repertoire in response to tubular antigen J Immunol 1985. 134:2375-82

» Mann, R, Zakheim, B, Clayman, M, McCafferty, E, Michaud, L, Neilson, E G Murine interstitial nephritis. IV. Long-term cultured L3T4+ T cell lines transfer delayed expression of disease as I-A-restricted inducers of the effector T cell repertoire J Immunol 1985. 135:286-93

» Clayman, M D, Martinez-Hernandez, A, Michaud, L, Alper, R, Mann, R, Kefalides, N A, Neilson, E G Isolation and characterization of the nephritogenic antigen producing anti-tubular basement membrane disease J Exp Med 1985. 161:290-305

» Neilson, E G, McCafferty, E, Phillips, S M, Clayman, M D, Kelly, C J Antiidiotypic immunity in interstitial nephritis. II. Rats developing anti-tubular basement membrane disease fail to make an antiidiotypic regulatory response: the modulatory role of an RT7.1+, OX8- suppressor T cell mechanism J Exp Med 1984. 159:1009-26

» Matsumoto, K, McCafferty, E, Neilson, E G, Gasser, D L Mapping of the genes for tubular basement membrane antigen and a submaxillary gland protease in the rat Immunogenetics 1984. 20:117-23

» Goldstein, C S, Bomalaski, J S, Zurier, R B, Neilson, E G, Douglas, S D Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients Kidney Int 1984. 26:733-40

» Neilson, E G, McCafferty, E, Feldman, A, Clayman, M D, Zakheim, B, Korngold, R Spontaneous interstitial nephritis in kdkd mice. I. An experimental model of autoimmune renal disease J Immunol 1984. 133:2560-5

» Zakheim, B, McCafferty, E, Phillips, S M, Clayman, M, Neilson, E G Murine interstitial nephritis. II. The adoptive transfer of disease with immune T lymphocytes produces a phenotypically complex interstitial lesion J Immunol 1984. 133:234-9

» Neilson, E G, Gasser, D L, McCafferty, E, Zakheim, B, Phillips, S M Polymorphism of genes involved in anti-tubular basement membrane disease in rats Immunogenetics 1983. 17:55-65

» Neilson, E G, Zakheim, B T cell regulation, anti-idiotypic immunity, and the nephritogenic immune response Kidney Int 1983. 24:289-302

» Neilson, E G, Phillips, M Suppression of interstitial nephritis by auto-anti-idiotypic immunity J Exp Med 1982. 155:179-89

» Neilson, E G, Phillips, S M Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune-response genes and a restrictive requirement for cytotoxic T cells at H-2K J Exp Med 1982. 155:1075-85

» Neilson, E G, Phillips, S M The immunobiology of nephritis Prog Allergy 1980. 27:167-249

» Neilson, E G, Jimenez, S A, Phillips, S M Cell-mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis: an immune mechanism for renal fibrogenesis J Immunol 1980. 125:1708-14

» Neilson, E G, Phillips, S M, Agus, Z Plasmapheresis in fulminating crescentic nephritis Lancet 1980. 1:264-5

» Neilson, E G, Phillips, S M Cell-mediated immunity in interstitial nephritis. I. T lymphocyte systems in nephritic guinea pigs: the natural history and diversity of the immune response J Immunol 1979. 123:2373-80

» Neilson, E G, Phillips, S M Cell-mediated immunity in interstitial nephritis. II. T lymphocyte effector mechanisms in nephritic guinea pigs: analysis of the renotropic migration and cytotoxic response J Immunol 1979. 123:2381-5