Center for Matrix Biology - Vanderbilt University and Medical Center

Samuel A. Santoro, M.D., Ph.D.
Professor in the Department of Pathology

	Office Address:	C-3322 MCN
	Mailing Address:	C-3322 MCN Nashville, TN 2561
	Lab address:	C-3322 MCN/CC-2201 MCN
	Phone:	322-3234
		email

Secondary appointment in the Biochemistry department.

Research Summary

The molecular mechanisms of cell-substrate adhesion and the biologic roles of cellular adhesion are the foci of our research program. Most of our studies are centered on the alpha 2/beta 1 integrin, a cell surface receptor for collagen that was originally identified and characterized in our laboratory. Current efforts are devoted to elucidation of the structural basis of ligand recognition by the integrin, the structural basis of integrin activation and the roles of the alpha 2/beta 1 and related integrins in complex biological processes such as differentiation, development, wound healing and repair, tumor cell invasion and metastasis, and hemostasis and thrombosis.

Ongoing projects include: 1) elucidation of the structural basis by which the integrin recognizes and binds both collagenous and noncollagenous ligands, 2) elucidation of the structural basis of integrin activation that permits higher affinity binding of some ligands or that is required for the binding of other ligands, 3) exploration of the role of altered integrin expression in the invasive and metastatic behavior of tumor cells, 4) definition of the structural and biologic basis of MMP-1 (matrix metalloproteinase-1) interactions with the integrin and the role of the interaction in regulating cell surface matrix metalloproteinase activity in wound repair and related events, 5) examination of the role of integrin-mediated cell-matrix interactions in the establishment and maintenance of the differentiated epithelial phenotype, and 6) and elucidation of the structural basis and pathbiologic function of the alpha 2/beta 1 integrin as a receptor for echoviruses and reoviruses. In addition, we continue to identify new ligands that implicate the alpha 2/beta 1 integrin in novel facets of biology and pathology.

Our studies combine the application of modern protein and peptide biochemistry, immunochemical and molecular genetic approaches (including knockout mice) to address the fundamental roles and mechanisms of cellular adhesion in complex cell biological processes. .

Research Keywords

Cancer, Knockout, Malignancy, Molecular medicine, Mouse, Pathology, Protein Structure, Receptor, Vascular Biology,

Printer Friendly

Associated initiative(s):

Biomaterials

Fibrosis

Tissue Regeneration

Wound Repair

Career opportunities:
Postdoctoral Position Available

Selected Publications

» Santoro, SA, Mosse, CA, Young, PP The MD/PhD pathway to a career in laboratory medicine Clin Lab Med 2007. 27:425-34; abstract ix

» Maginnis, MS, Forrest, JC, Kopecky-Bromberg, SA, Dickeson, SK, Santoro, SA, Zutter, MM, Nemerow, GR, Bergelson, JM, Dermody, TS Beta1 integrin mediates internalization of mammalian reovirus J Virol 2006. 80:2760-70

» Bix, G, Fu, J, Gonzalez, EM, Macro, L, Barker, A, Campbell, S, Zutter, MM, Santoro, SA, Kim, JK, H????k, M, Reed, CC, Iozzo, RV Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin J Cell Biol 2004. 166:97-109

» Wang, Hui, Fu, Weili, Im, Jae Hong, Zhou, Zengyi, Santoro, Samuel A., Iyer, Vandana, DiPersio, C. Mike, Yu, Qian-Chun, Quaranta, Vito, Al-Mehdi, Abu, Muschel, Ruth J. Tumor cell {alpha}3{beta}1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis J Cell Biol 2004. 164:935-941

» Grenache, David G, Coleman, Trey, Semenkovich, Clay F, Santoro, Samuel A, Zutter, Mary M Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk Arterioscler Thromb Vasc Biol 2003. 23:2104-9

» He, Li, Pappan, Loretta K, Grenache, David G, Li, Zhengzhi, Tollefsen, Douglas M, Santoro, Samuel A, Zutter, Mary M The contributions of the {alpha}2{beta}1 integrin to vascular thrombosis in vivo Blood 2003. 102:3652-3657

» Chen, Jianchun, Diacovo, Thomas G, Grenache, David G, Santoro, Samuel A, Zutter, Mary M The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis Am J Pathol 2002. 161:337-44

» Stricker, T P, Dumin, J A, Dickeson, S K, Chung, L, Nagase, H, Parks, W C, Santoro, S A Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction J Biol Chem 2001. 276:29375-81

» Klekotka, P A, Santoro, S A, Zutter, M M alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK J Biol Chem 2001. 276:9503-11

» Klekotka, P A, Santoro, S A, Ho, A, Dowdy, S F, Zutter, M M Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain Am J Pathol 2001. 159:983-92

» Klekotka, P A, Santoro, S A, Wang, H, Zutter, M M Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways J Biol Chem 2001. 276:32353-61

» Ohman, T, King, S L, Krithivas, A, Cunningham, J, Dickeson, S K, Santoro, S A, Bergelson, J M Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain Virus Res 2001. 76:1-8

» Dumin, J A, Dickeson, S K, Stricker, T P, Bhattacharyya-Pakrasi, M, Roby, J D, Santoro, S A, Parks, W C Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen J Biol Chem 2001. 276:29368-74

» Ding, Q, Gladson, C L, Guidry, C R, Santoro, S A, Dickeson, S K, Shin, J T, Thompson, J A Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility Growth Factors 2000. 18:93-107

» Wang, H, Gai, Q, Yang, X, Li, Z, Linders, B, Santoro, S A, Zutter, M M Role of the alpha1 and alpha2 integrin cytoplasmic domains in cell morphology, motility and responsiveness to stimulation by the protein kinase C pathway Cell Adhes Commun 2000. 7:281-97

» Keene, D R, San Antonio, J D, Mayne, R, McQuillan, D J, Sarris, G, Santoro, S A, Iozzo, R V Decorin binds near the C terminus of type I collagen J Biol Chem 2000. 275:21801-4

» Dickeson, S K, Mathis, N L, Rahman, M, Bergelson, J M, Santoro, S A Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins J Biol Chem 1999. 274:32182-91

» Zutter, M M, Santoro, S A, Wu, J E, Wakatsuki, T, Dickeson, S K, Elson, E L Collagen receptor control of epithelial morphogenesis and cell cycle progression Am J Pathol 1999. 155:927-40

» Santoro, S A Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk Blood 1999. 93:3575-7

» Hamerski, D A, Santoro, S A, Integrins and the kidney: biology and pathobiology. Curr Opin Nephrol Hypertens 1999. 8:9-14

» Sun, H, Santoro, S A, Zutter, M M Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits Cancer Res 1998. 58:2224-33

» Xu, J, Zutter, M M, Santoro, S A, Clark, R A A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling J Cell Biol 1998. 140:709-19

» Bhattacharyya-Pakrasi, M, Dickeson, S K, Santoro, S A, Alpha2beta1 integrin recognition of the carboxyl-terminal propeptide of type I procollagen: integrin recognition and feed-back regulation of matrix biosynthesis are mediated by distinct sequences. Matrix Biol 1998. 17:223-32

» Zutter, M M, Sun, H, Santoro, S A Altered integrin expression and the malignant phenotype: the contribution of multiple integrated integrin receptors J Mammary Gland Biol Neoplasia 1998. 3:191-200

» Dickeson, S K, Walsh, J J, Santoro, S A, Binding of the alpha 2 integrin I domain to extracellular matrix ligands: structural and mechanistic differences between collagen and laminin binding. Cell Adhes Commun 1998. 5:273-81

» Dickeson, S K, Bhattacharyya-Pakrasi, M, Mathis, N L, Schlesinger, P H, Santoro, S A Ligand binding results in divalent cation displacement from the alpha 2 beta 1 integrin I domain: evidence from terbium luminescence spectroscopy Biochemistry 1998. 37:11280-8

» Dickeson, S K, Santoro, S A Ligand recognition by the I domain-containing integrins Cell Mol Life Sci 1998. 54:556-66

» Zutter, M M, Santoro, S A The ups and downs of alpha 2 beta 1-integrin expression: contributions to epithelial cell differentiation and the malignant phenotype Curr Top Microbiol Immunol 1998. 231:167-85

» Staatz, W D, Walsh, J J, Santoro, S A The alpha 2 beta 1 integrin binds to the CB4 peptide of the alpha 2(I) collagen chain Biochem Mol Biol Int 1997. 42:577-82

» Despotis, G J, Ikonomakou, S, Levine, V, Joiner-Maier, D, Santoro, S A, Joist, J H Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood Thromb Res 1997. 86:205-19

» Despotis, G J, Levine, V, Joist, H, Santoro, S A, Mendeloff, E Multiple episodes of thrombosis with biventricular support devices with inadequate anticoagulation and evidence of accelerated intravascular coagulation J Thorac Cardiovasc Surg 1997. 113:419-22

» Dickeson, S K, Walsh, J J, Santoro, S A Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin J Biol Chem 1997. 272:7661-8

» Despotis, G J, Joist, J H, Goodnough, L T, Santoro, S A, Spitznagel, E Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements J Thorac Cardiovasc Surg 1997. 113:611-3

» Windus, D W, Santoro, S A, Atkinson, R, Royal, H D Effects of antiplatelet drugs on dialysis-associated platelet deposition in polytetrafluoroethylene grafts Am J Kidney Dis 1997. 29:560-4

» Dieckgraefe, B K, Weems, D M, Santoro, S A, Alpers, D H ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction Biochem Biophys Res Commun 1997. 233:389-94

» Xu, J, Zutter, M M, Santoro, S A, Clark, R A PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta J Cell Biol 1996. 134:1301-11

» Despotis, G J, Levine, V, Filos, K S, Santoro, S A, Joist, J H, Spitznagel, E, Goodnough, L T Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients Anesthesiology 1996. 85:1311-23

» Despotis, G J, Joist, J H, Hogue, C W, Alsoufiev, A, Joiner-Maier, D, Santoro, S A, Spitznagel, E, Weitz, J I, Goodnough, L T More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT Thromb Haemost 1996. 76:902-8

» Windus, DW, Atkinson, R, Santoro, S The effects of hemodialysis on platelet activation with new and reprocessed regenerated cellulose dialyzers Am J Kidney Dis 1996. 27:387-93

» Wu, J E, Santoro, S A Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis Dev Dyn 1996. 206:169-81

» Despotis, G J, Alsoufiev, A, Hogue, C W, Zoys, T N, Goodnough, L T, Santoro, S A, Kater, K M, Barnes, P, Lappas, D G Evaluation of complete blood count results from a new, on-site hemocytometer compared with a laboratory-based hemocytometer Crit Care Med 1996. 24:1163-7

» Dieckgraefe, B K, Santoro, S A, Alpers, D H Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis Gastroenterology 1996. 110:58-71

» Windus, DW, Santoro, S, Royal, HD The effects of hemodialysis on platelet deposition in prosthetic graft fistulas Am J Kidney Dis 1995. 26:614-21

» Despotis, G J, Joist, J H, Joiner-Maier, D, Alsoufiev, A L, Triantafillou, A N, Goodnough, L T, Santoro, S A, Lappas, D G Effect of aprotinin on activated clotting time, whole blood and plasma heparin measurements Ann Thorac Surg 1995. 59:106-11

» Keely, P J, Fong, A M, Zutter, M M, Santoro, S A Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells J Cell Sci 1995. 108 ( Pt 2):595-607

» Keely, P J, Wu, J E, Santoro, S A The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis Differentiation 1995. 59:1-13

» Despotis, G J, Joist, J H, Hogue, C W, Alsoufiev, A, Kater, K, Goodnough, L T, Santoro, S A, Spitznagel, E, Rosenblum, M, Lappas, D G The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation J Thorac Cardiovasc Surg 1995. 110:46-54

» Zutter, M M, Santoro, S A, Staatz, W D, Tsung, Y L Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells Proc Natl Acad Sci U S A 1995. 92:7411-5

» Santoro, S A, Zutter, M M The alpha 2 beta 1 integrin: a collagen receptor on platelets and other cells Thromb Haemost 1995. 74:813-21

» Despotis, G J, Hogue, C W, Santoro, S A, Joist, J H, Barnes, P W, Lappas, D G Effect of heparin on whole blood activated partial thromboplastin time using a portable, whole blood coagulation monitor Crit Care Med 1995. 23:1674-9

» Saelman, E U, Keely, P J, Santoro, S A Loss of MDCK cell alpha 2 beta 1 integrin expression results in reduced cyst formation, failure of hepatocyte growth factor/scatter factor-induced branching morphogenesis, and increased apoptosis J Cell Sci 1995. 108 ( Pt 11):3531-40

» Fong, A M, Santoro, S A Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element J Biol Chem 1994. 269:18441-7

» Santoro, S A Antiphospholipid antibodies and thrombotic predisposition: underlying pathogenetic mechanisms Blood 1994. 83:2389-91

» Zutter, M M, Santoro, S A, Painter, A S, Tsung, Y L, Gafford, A The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression J Biol Chem 1994. 269:463-9

» Despotis, G J, Summerfield, A L, Joist, J H, Goodnough, L T, Santoro, S A, Zimmermann, J J, Lappas, D G In vitro reversal of heparin effect with heparinase: evaluation with whole blood prothrombin time and activated partial thromboplastin time in cardiac surgical patients Anesth Analg 1994. 79:670-4

» Choi, ET, Engel, L, Callow, AD, Sun, S, Trachtenberg, J, Santoro, S, Ryan, US Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA J Vasc Surg 1994. 19:125-34

» Despotis, G J, Santoro, S A, Spitznagel, E, Kater, K M, Cox, J L, Barnes, P, Lappas, D G Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation J Thorac Cardiovasc Surg 1994. 107:271-9

» Santoro, S A, Zutter, M M, Wu, J E, Staatz, W D, Saelman, E U, Keely, P J Analysis of collagen receptors Methods Enzymol 1994. 245:147-83

» Despotis, G J, Summerfield, A L, Joist, J H, Goodnough, L T, Santoro, S A, Spitznagel, E, Cox, J L, Lappas, D G Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations J Thorac Cardiovasc Surg 1994. 108:1076-82

» Despotis, G J, Santoro, S A, Spitznagel, E, Kater, K M, Barnes, P, Cox, J L, Lappas, D G On-site prothrombin time, activated partial thromboplastin time, and platelet count. A comparison between whole blood and laboratory assays with coagulation factor analysis in patients presenting for cardiac surgery Anesthesiology 1994. 80:338-51

» Wu, J E, Santoro, S A Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development Dev Dyn 1994. 199:292-314

» Winters, K J, Walsh, J J, Rubin, B G, Santoro, S A Platelet interactions with fibronectin: divalent cation-independent platelet adhesion to the gelatin-binding domain of fibronectin Blood 1993. 81:1778-86

» Zutter, M M, Krigman, H R, Santoro, S A Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization Am J Pathol 1993. 142:1439-48

» Rubin, B G, Santoro, S A, Sicard, G A Platelet interactions with the vessel wall and prosthetic grafts Ann Vasc Surg 1993. 7:200-7

» Rubin, B G, McGraw, D J, Sicard, G A, Santoro, S A New RGD analogue inhibits human platelet adhesion and aggregation and eliminates platelet deposition on canine vascular grafts J Vasc Surg 1992. 15:683-91; discussion 691-2

» Zutter, M M, Fong, A M, Krigman, H R, Santoro, S A Differential regulation of the alpha 2 beta 1 and alpha IIb beta 3 integrin genes during megakaryocytic differentiation of pluripotential K562 cells J Biol Chem 1992. 267:20233-8

» Burger, S R, Zutter, M M, Sturgill-Koszycki, S, Santoro, S A Induced cell surface expression of functional alpha 2 beta 1 integrin during megakaryocytic differentiation of K562 leukemic cells Exp Cell Res 1992. 202:28-35

» Pacifici, R, Basilico, C, Roman, J, Zutter, M M, Santoro, S A, McCracken, R Collagen-induced release of interleukin 1 from human blood mononuclear cells. Potentiation by fibronectin binding to the alpha 5 beta 1 integrin J Clin Invest 1992. 89:61-7

» Hortin, G L, Staatz, W D, Santoro, S A Preparation of soluble peptide libraries: application to studies of platelet adhesion sequences Biochem Int 1992. 26:731-8

» Winters, K J, Santoro, S A, Miletich, J P, Eisenberg, P R Relative importance of thrombin compared with plasmin-mediated platelet activation in response to plasminogen activation with streptokinase Circulation 1991. 84:1552-60

» Pacifici, R, Carano, A, Santoro, S A, Rifas, L, Jeffrey, J J, Malone, J D, McCracken, R, Avioli, L V Bone matrix constituents stimulate interleukin-1 release from human blood mononuclear cells J Clin Invest 1991. 87:221-8

» Staatz, W D, Fok, K F, Zutter, M M, Adams, S P, Rodriguez, B A, Santoro, S A Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen J Biol Chem 1991. 266:7363-7

» Santoro, S A, Walsh, J J, Staatz, W D, Baranski, K J Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation Cell Regul 1991. 2:905-13

» Zutter, M M, Mazoujian, G, Santoro, S A Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast Am J Pathol 1990. 137:863-70

» Zutter, M M, Santoro, S A Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptor Am J Pathol 1990. 137:113-20

» Staatz, W D, Peters, K J, Santoro, S A Divalent cation-dependent structure in the platelet membrane glycoprotein Ia-IIa (VLA-2) complex Biochem Biophys Res Commun 1990. 168:107-14

» Winters, K J, Eisenberg, P R, Jaffe, A S, Santoro, S A Dependence of plasmin-mediated degradation of platelet adhesive receptors on temperature and Ca2+ Blood 1990. 76:1546-57

» Staatz, W D, Walsh, J J, Pexton, T, Santoro, S A The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen J Biol Chem 1990. 265:4778-81

» Torr, S R, Winters, K J, Santoro, S A, Sobel, B E The nature of interactions between tissue-type plasminogen activator and platelets Thromb Res 1990. 59:279-93

» Love, P E, Santoro, S A Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance Ann Intern Med 1990. 112:682-98

» Staatz, W D, Rajpara, S M, Wayner, E A, Carter, W G, Santoro, S A The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen J Cell Biol 1989. 108:1917-24

» Hawrylowicz, C M, Santoro, S A, Platt, F M, Unanue, E R Activated platelets express IL-1 activity J Immunol 1989. 143:4015-8

» McGoff, M A, Allen, B T, Der, T, Sicard, G A, Santoro, S A Mechanisms of vascular graft thrombosis: role of altered canine platelet sensitivity to thromboxane Thromb Res 1989. 55:695-707

» Santoro, S A Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by complex gangliosides Blood 1989. 73:484-9

» Santoro, S A, Lawing, W J Modulation of an RGDS binding site on the platelet membrane glycoprotein IIb-IIIa complex Biochem Biophys Res Commun 1989. 160:189-95

» Santoro, S A Molecular basis of platelet adhesion to collagen Prog Clin Biol Res 1988. 283:291-314

» Santoro, S A, Rajpara, S M, Staatz, W D, Woods, V L Isolation and characterization of a platelet surface collagen binding complex related to VLA-2 Biochem Biophys Res Commun 1988. 153:217-23

» Bourey, R E, Santoro, S A Interactions of exercise, coagulation, platelets, and fibrinolysis--a brief review Med Sci Sports Exerc 1988. 20:439-46

» Hortin, G L, Tollefsen, D M, Santoro, S A Assessment of interference by heparin cofactor II in the DuPont aca antithrombin-III assay Am J Clin Pathol 1988. 89:515-7

» Santoro, S A, Frazier, W A Isolation and characterization of thrombospondin Methods Enzymol 1987. 144:438-46

» Santoro, S A, Lawing, W J Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins Cell 1987. 48:867-73

» Santoro, S A The dualistic mechanisms of platelet adhesion to von Willebrand factor substrates Exp Cell Res 1987. 173:413-24

» Santoro, S A Thrombospondin and the adhesive behavior of platelets Semin Thromb Hemost 1987. 13:290-7

» Santoro, S A Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen Cell 1986. 46:913-20

» Santoro, S A, Cowan, J F Thrombin enhanced adhesion of platelets to von Willebrand factor substrates Thromb Res 1986. 43:57-72

» Dixit, V M, Haverstick, D M, O''Rourke, K, Hennessy, S W, Broekelmann, T J, McDonald, J A, Grant, G A, Santoro, S A, Frazier, W A Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin Proc Natl Acad Sci U S A 1985. 82:3844-8

» Dixit, V M, Haverstick, D M, O''Rourke, K M, Hennessy, S W, Grant, G A, Santoro, S A, Frazier, W A A monoclonal antibody against human thrombospondin inhibits platelet aggregation Proc Natl Acad Sci U S A 1985. 82:3472-6

» Haverstick, D M, Dixit, V M, Grant, G A, Frazier, W A, Santoro, S A Characterization of the platelet agglutinating activity of thrombospondin Biochemistry 1985. 24:3128-34

» Dixit, V M, Haverstick, D M, O''Rourke, K M, Hennessy, S W, Grant, G A, Santoro, S A, Frazier, W A Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin Biochemistry 1985. 24:4270-5

» Cornelison, G S, Rollins, A, Santoro, S A Duplicate coagulation assays warranted Am J Clin Pathol 1985. 84:261-2

» Haverstick, D M, Cowan, J F, Yamada, K M, Santoro, S A Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin Blood 1985. 66:946-52

» Galvin, N J, Dixit, V M, O''Rourke, K M, Santoro, S A, Grant, G A, Frazier, W A Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing J Cell Biol 1985. 101:1434-41

» Roberts, D D, Haverstick, D M, Dixit, V M, Frazier, W A, Santoro, S A, Ginsburg, V The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids J Biol Chem 1985. 260:9405-11

» Shafer, K E, Santoro, S A, Sobel, B E, Jaffe, A S Monitoring activity of fibrinolytic agents. A therapeutic challenge Am J Med 1984. 76:879-86

» Dixit, V M, Grant, G A, Frazier, W A, Santoro, S A Isolation of the fibrinogen-binding region of platelet thrombospondin Biochem Biophys Res Commun 1984. 119:1075-81

» Dixit, V M, Grant, G A, Santoro, S A, Frazier, W A Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin J Biol Chem 1984. 259:10100-5

» Haverstick, D M, Dixit, V M, Grant, G A, Frazier, W A, Santoro, S A Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment Biochemistry 1984. 23:5597-603

» Santoro, S A, Cowan, J F Mechanism of inhibition by trinitrophenylation of the ristocetin cofactor activity of von Willebrand factor Biochim Biophys Acta 1984. 797:178-85

» Santoro, S A Inhibition of platelet aggregation by fibronectin Biochem Biophys Res Commun 1983. 116:135-40

» Santoro, S A Differential effects of concanavalin A and succinyl concanavalin A on the macromolecular events of platelet activation Biochim Biophys Acta 1983. 757:101-10

» Santoro, S A Preferential binding of high molecular weight forms of von Willebrand factor to fibrillar collagen Biochim Biophys Acta 1983. 756:123-6

» Santoro, S A Amino group modification inhibits ristocetin cofactor activity of human von Willebrand factor Biochem Biophys Res Commun 1982. 108:479-85

» Santoro, S A, Cunningham, L W Platelet-collagen adhesion Methods Enzymol 1982. 82 Pt A:509-13

» Santoro, S A, Cowan, J F Adsorption of von Willebrand factor by fibrillar collagen--implications concerning the adhesion of platelets to collagen Coll Relat Res 1982. 2:31-43

» Santoro, S A, Cunningham, L W Platelet-collagen adhesion-membrane fluidity and the development of high affinity adhesion through multiple interacting sites Coll Relat Res 1981. 1:517-26

» Santoro, S A Adsorption of von Willebrand factor/factor VIII by the genetically distinct interstitial collagens Thromb Res 1981. 21:689-91

» Santoro, S A, Cunningham, L W Collagen-mediated platelet aggregation: the role of multiple interactions between the platelet surface and collagen Thromb Haemost 1980. 43:158-62

» Santoro, S A, Cunningham, L W Fibronectin and the multiple interaction model for platelet-collagen adhesion Proc Natl Acad Sci U S A 1979. 76:2644-8

» Cunningham, LW, Santoro, S, Davies, H Primary hemostasis (collagen-platelet interaction): introduction Suppl Thromb Haemost 1978. 63:205-13

» Santoro, S A, Cunningham, L W Collagen-mediated platelet aggregation. Evidence for multivalent interactions of intermediate specificity between collagen and platelets J Clin Invest 1977. 60:1054-60