Center for Matrix Biology - Vanderbilt University and Medical Center

Matthew D. Breyer, M.D.
Adjunct Professor in the Department of Medicine

	Office Address:	Biotechnology Discovery Research
	Mailing Address:	355 E. Merrill Street Biotechnology Discovery Research Nashville, TN 46225
	Lab address:
		email

Research Summary

We?re studying the gnenetic mechanisms underlying diabetic kidney disease (diabetic nephropathy or DN), the major cause of kidney failure in the U.S. Of people with diabetes mellitus, only a minority (~30%) get diabetic nephropathy. This is the result of an underlying genetic predispostion. Identification of the relevant genes in people has been slow because the mixed genetic background and diverse environmental factors. We are therefore characterizing the modifier genes causing DN in inbred mouse strains.
Roles for lipid mediators in the genesis of DN, especially cyclooxygenase derived prostaglandins, are another special area of interest.. All type II Diabetic patients are recommended to be on low dose aspirin to prevent cardiovascular problems. The importance of prostaglandins to systemic injury, is underscored by the fact that potent therapeutic drugs Motrin, Aspirin, and other Non-steroidal anti-inflammatory drugs (NSAIDs), all act by blocking the synthesis of prostaglandins via cyclooxygenases (COX1 or COX2). We are testing the hypothesis that changes in prostaglandin synthesis are integral to the development of DN, renal injury and regeneration of the injured kidney.
Finally, once synthesized prostaglandins activate several different families of receptors including nuclear receptors (PPARgamma) and G-protein coupled receptors. The roles of these different receptors are being studied in knockout mice with and without diabetes. Roles for prostaglandins in promoting renal regeneration, cell survival and stem cell differentiation are also being examined in the context of dehydration and diabetes mellitus. .

Research Keywords

Apoptosis, Developmental biology, Diabetes, Genetics, Kidney, Knockout, Molecular medicine, Mouse, Pathology, Physiology, Renal biology, Stem cells,

Printer Friendly

Associated initiative(s):

Diabetic Complications

Career opportunities:
None currently available

Selected Publications

» Breyer, MD, B??ttinger, E, Brosius, FC, Coffman, TM, Harris, RC, Heilig, CW, Sharma, K, , Mouse models of diabetic nephropathy J Am Soc Nephrol 2005. 16:27-45

» Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria Am J Physiol Renal Physiol 2005. 288:F642-9

» Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition Nephron Exp Nephrol 2005. 101:e75-85

» Guan, Y, Hao, C, Cha, DR, Rao, R, Lu, W, Kohan, DE, Magnuson, MA, Redha, R, Zhang, Y, Breyer, MD Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption Nat Med 2005. 11:861-6

» Qi, Z, Fujita, H, Jin, J, Davis, LS, Wang, Y, Fogo, AB, Breyer, MD Characterization of susceptibility of inbred mouse strains to diabetic nephropathy Diabetes 2005. 54:2628-37

» Schneider, A, Guan, Y, Zhang, Y, Magnuson, MA, Pettepher, C, Loftin, CD, Langenbach, R, Breyer, RM, Breyer, MD Generation of a conditional allele of the mouse prostaglandin EP4 receptor Genesis 2004. 40:7-14

» Rao, R, Hao, CM, Breyer, MD Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway J Biol Chem 2004. 279:3949-55

» Schneider, A, Zhang, Y, Zhang, M, Lu, WJ, Rao, R, Fan, X, Redha, R, Davis, L, Breyer, RM, Harris, R, Guan, Y, Breyer, MD Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney Kidney Int 2004. 65:1205-13

» Qi, Z, Whitt, I, Mehta, A, Jin, J, Zhao, M, Harris, RC, Fogo, AB, Breyer, MD Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance Am J Physiol Renal Physiol 2004. 286:F590-6

» Ma, J., L King, R Maronpot, LS Davis, MD Breyer, DC Zeldin. Molecular cloning of mouse CYP2J6: An unstable cytochrome p450 isoform highly expressed in intestinal epithelial cells. (Submitted, Mol. Pharm.).

» Peti-Peterdi J, Komlosi P, Fuson AL, Guan Y, Schneider A, Qi Z, Redha R, Rosivall L, Breyer MD, Bell PD Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells J. Clin. Invest. 2003. 112:76-82

» Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress J Biol Chem. 2003. 278:19352-7

» Schneider A, Zhang Y, Guan Y, Davis LS, Breyer MD Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice Am J Physiol Renal Physiol. 2003. 284:F411-7.

» Saito O, Guan Y, Qi Z, Davis LS, Komhoff M, Sugimoto Y, Narumiya S, Breyer RM, Breyer MD Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract Am J Physiol Renal Physiol 2003. 284:F1164-70

» Saito, O, Guan, Y, Qi, Z, Davis, LS, K??mhoff, M, Sugimoto, Y, Narumiya, S, Breyer, RM, Breyer, MD Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract Am J Physiol Renal Physiol 2003. 284:F1164-70

» Davidson, JM, Breyer, MD Inflammatory modulation and wound repair J Invest Dermatol 2003. 120:xi-xii

» Moeckel, GW, Zhang, L, Fogo, AB, Hao, CM, Pozzi, A, Breyer, MD COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress J Biol Chem 2003. 278:19352-7

» Qi, Zhonghua; Chuanming Hao; RL Langenbach, RM Breyer, Reyadh Redha, Jason Morrow, MD Breyer Opposite effects of Cyclooxygensases-1 and -2 activity on the pressor response to angiotensin II J. Clin. Invest. 2002. 110:61-69

» Hao, CM, R Redha J Morrow, MD Breyer Peroxisome Proliferator activated receptor delta activation promotes cell survival following hypertonic stress Journal of Biological Chemistry 2002. 277:21341-21345

» Shappell, SB, S Manning, WE Boeglin, YF Guan, L Davis, GS Jack, CS Coffey, TM Wheeler, MD Breyer, and AR Brash. Alterations in Lipoxygenase and Cyclooxygenase expression in prostate carcinoma. (In press, Neoplasia).

» Breyer, RM, Kennedy, CR, Zhang, Y, Guan, Y, Breyer, MD Targeted gene disruption of the prostaglandin E2 EP2 receptor Adv Exp Med Biol 2002. 507:321-6

» Guan, Y, LS Davis, Brett Stillman, YW, Zhang, HR Jacobson, RM Breyer, MD Breyer Cloning and expression of the rabbit Prostaglandin EP2 receptor BMC Pharmacol 2002. 2:14-22

» Guan, Y, Stillman, BA, Zhang, Y, Schneider, A, Saito, O, Davis, LS, Redha, R, Breyer, RM, Breyer, MD Cloning and expression of the rabbit prostaglandin EP2 receptor BMC Pharmacol 2002. 2:14

» Qi, Z, Hao, CM, Langenbach, RI, Breyer, RM, Redha, R, Morrow, JD, Breyer, MD Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II J Clin Invest 2002. 110:61-9

» Zheng F, Fornoni A, Elliot SJ, Guan Y, Breyer MD, Striker LJ, Striker GE Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma activation Am J Physiol Renal Physiol. 2002. 282:F639-48

» Holla, V., F. Adas, J. Imig. X. Zhao, E. Price, N. Olsen, WS Kovacs, MA Magnuson, DS Keeney, MD Breyer, JR Falck, MR Waterman, JH Capdevila Alterations in the regulation of androgen sensitive CYP4a Monooxygenases cause hypertension Proc. Natl. Acad. Sci. USA 2001. 98:5211-5216

» Qu, W. JA Bradbury, CC Tsao, R Maronpot, JG Harry, LS Davis, MD Breyer, JR Falck, J Chen, RL Rosenberg, and DC Zeldin Cloning, characterization and Functional Significance of CYP2J9, a New Mouse Cytochrome P440 Arachidonic Acid omega-1 Hydroxylase Abundant in Brain J. Biol. Chem. 2001. 276:25467-25479

» Breyer, M.D., and Breyer, R.M G-protein coupled prostanoid receptors and the kidney Annu. Rev. Physiol. 2001. :579-605

» Breyer, R.M., Bagdassarian, C.K., Myers, S.A., and Breyer, M.D Prostanoid receptors: subtypes and signaling Ann. Rev. Pharmacol. Toxicol 2001. 41:661-690

» Guan, YF and Breyer, MD Peroxisome Proliferator activated receptors (PPARs): Novel Therapeutic targets in renal disease Kidney Int 2001. 60:14-30

» Breyer, M.D., and Harris, R.C Cyclooxygenase-2 selective NSAIDs and the kidney Current Opinions in Nephrology and Hypertension 2001. 10:89-98

» Harris, R.C., and Breyer, M.D Physiologic regulation of cyclooxygenase-2 in the kidney Am. J. Physiol.: Renal Physiol. 2001. 281:F1-F11

» Breyer, M.D., and Qi, Z.H. Cyclooxygenase 2 inhibitors and the kidney. Current Opinions in Ciritcal Care Medicine. (In press, 2001).

» Guan, YF., A Schneider, YH Zhang, RM Breyer, MD Breyer Expression and function of peroxisome proliferator activated receptor gamma in rabbit glomerulus and medullary microvasculature Am. J. Physiol 2001. 281:F1036-1046

» Breyer, MD, Hao, C, Qi, Z Cyclooxygenase-2 selective inhibitors and the kidney Curr Opin Crit Care 2001. 7:393-400

» Guan, Y, Zhang, Y, Schneider, A, Riendeau, D, Mancini, JA, Davis, L, K??mhoff, M, Breyer, RM, Breyer, MD Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase Am J Physiol Renal Physiol 2001. 281:F1173-7

» Guan, Y, Zhang, Y, Schneider, A, Davis, L, Breyer, RM, Breyer, MD Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature Am J Physiol Renal Physiol 2001. 281:F1036-46

» Breyer, MD, Harris, RC Cyclooxygenase 2 and the kidney Curr Opin Nephrol Hypertens 2001. 10:89-98

» Breyer, MD, Breyer, RM G protein-coupled prostanoid receptors and the kidney Annu Rev Physiol 2001. 63:579-605

» Guan, YF, YH Zhang, A Schneider, D. Riendeau, JA Mancini, L Davis, M K?mhoff, RM Breyer, and MD Breyer Urogenital Distribution of a mouse membrane associated prostaglandin E2 synthase (mPGES) Am. J. Physiol. 2001. 281:F1173-1177

» Hao, CM, Yull, F, Blackwell, T, K??mhoff, M, Davis, LS, Breyer, MD Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells J Clin Invest 2000. 106:973-82

» K??mhoff, M, Jeck, ND, Seyberth, HW, Gr??ne, HJ, N??sing, RM, Breyer, MD Cyclooxygenase-2 expression is associated with the renal macula densa of patients with Bartter-like syndrome Kidney Int 2000. 58:2420-4

» K??mhoff, M, Wang, JL, Cheng, HF, Langenbach, R, McKanna, JA, Harris, RC, Breyer, MD Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development Kidney Int 2000. 57:414-22

» Zhang, Y, Guan, Y, Schneider, A, Brandon, S, Breyer, RM, Breyer, MD Characterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors Hypertension 2000. 35:1129-34

» K??mhoff, M, Guan, Y, Shappell, HW, Davis, L, Jack, G, Shyr, Y, Koch, MO, Shappell, SB, Breyer, MD Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas Am J Pathol 2000. 157:29-35

» K?mhoff, M., Nusing, R., Seyberth, H., and Breyer, M.D COX2 expression in macula densa of Bartter syndrome kidneys Kidney Int 2000. 58:2420-2424

» K?mhoff, M., Guan, YF, HW Shappell, LS Davis, G Jack, Y. Shyr, M. Koch, S.B. Shappell, and MD Breyer Enhanced Expression of Cyclooxygenase-2 in High Grade Human Transitional Cell Bladder Carcinomas American Jour. Pathology 2000. 157:29-35

» Komhoff, M, Wang, S, McKanna, JM, Langenbach, RC, Harris, RC, MD Breyer Cyclooxygenase 2 inhibition impairs glomerulogenesis and renal cortical development Kidney Int 2000. 57:414-422

» Hao, CM, F. Yull, M K?mhoff, T. Blackwell, LS Davis MD Breyer Dehydration activates a NF-kappaB driven COX2 dependent survival mechanism in renal medullary interstitial cells J. Clin. Invest. 2000. 106:973-982

» YH Zhang, YF Guan, A Schneider, S Brandon, RM Breyer, and MD Breyer Characterization of Murine Vasopressor and Vasodepressor Prostaglandin E2 Receptors Hypertension 2000. 35:1129-34

» Guan, YF, Zhang, YH, Breyer, RM, Davis, L, Breyer, MD Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death Neoplasia 1999. 1:330-9

» Kennedy, CRJ, Y. Zhang, S Brandon, YF Guan, K. Coffee, CD Funk, MA Magnuson, JA Oates, MD Breyer, RM Breyer Hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor Nature Medicine 1999. 5:217-220

» Guan, Y-F, YW Zhang, RM Breyer, LS Davis, MD Breyer Expression of Peroxisome Proliferator-Activated Receptor-g (PPARg) in human bladder cancer and its role inducing cell death Neoplasia 1999. 1:330-339

» Stillman, BA, MD Breyer, RM Breyer Importance of the extracellular domain for prostaglandin EP2 receptor function Mol. Pharmacol 1999. 56:545-551

» Hao, CM, M. Komhoff, YF Guan, RF Redha, MD Breyer Selective targeting of cyclooxygenase 2 reveals its role in renal medullary interstitial cell survival Am. J. Physiol 1999. 277:F352-359

» Ma, J., W. Qu, PE Scarborough, KB Tomer, CR Moomaw, R. Maronpot, LS Davis MD Breyer, and DC Zeldin Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney J. Biol. Chem. 1999. 274:17777-17788

» Qi, Z, C-M Hao, K Salter, RF Redha, and MD Breyer Cyclic AMP dependent protein kinase type II regulates electrogenic ion transport in rabbit collecting duct Am. J. Physiol. 1999. 276:F622-628

» Audoly, L., LJ Ma, I Feoktistov, MD Breyer, RM Breyer EP3 receptor activation of cAMP response element mediated gene transcription J. Pharmacol. Exp. Ther. 1999. 289:140-148

» Kennedy, CR, Zhang, Y, Brandon, S, Guan, Y, Coffee, K, Funk, CD, Magnuson, MA, Oates, JA, Breyer, MD, Breyer, RM Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor Nat Med 1999. 5:217-20

» Hao, CM, K??mhoff, M, Guan, Y, Redha, R, Breyer, MD Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival Am J Physiol 1999. 277:F352-9

» Stillman, BA, Breyer, MD, Breyer, RM Importance of the extracellular domain for prostaglandin EP(2) receptor function Mol Pharmacol 1999. 56:545-51

» Guan,YF, YH Zhang, RM. Breyer, B Fowler, LS Davis, RL H้bert, MD Breyer PGE2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor J. Clin. Invest 1998. 102:194-201

» Guan, Y, Zhang, Y, Breyer, RM, Fowler, B, Davis, L, H??bert, RL, Breyer, MD Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor J Clin Invest 1998. 102:194-201

» Guan, Y, M. Chang, W-Y Cho, YW, Zhang, R Redha, LS Davis, S Chang, RN DuBois, CM Hao, MD Breyer Cloning expression and regulation of rabbit Cyclooxygenase-2 in renal medullary interstitial cells Am. J. Physiol. 1997. 273:F18-26

» Chang, MS, JC Tsai, R. Yang. RN DuBois, MD Breyer, DM O'Day Induction of cyclooxygenase-2 in the anterior uvea after glaucoma filtration surgery in rabbits Curr Eye Res 1997. 16:1147-1151

» Guan, Y, YW Zhang, LS Davis, MD Breyer Expression of peroxisome proliferator activated receptors in urinary tract of rabbit and man Am. J. Physiol. 1997. 273:F1013-1022

» Hao, C-M, RM Breyer, LS Davis, and MD Breyer Intra-renal distribution of Rabbit PKC-zeta Kidney Int 1997. 1831-1837: 51

» Breyer, RM, Y Guan, R Redha, LS Davis, C. Nian, HR Jacobson, and MD Breyer Cloning and expression of the rabbit prostaglandin EP4 receptor Am. J. Physiol. 1996. 270:F485-493

» Breyer MD, LS Davis, HR Jacobson, and RM Breyer Differential localization of Prostaglandin E receptor subtypes in human kidney Am. J. Physiol. 1996. 270:F912-918

» Breyer MD, and D Fredin Effect of vasopressin on intracellular Na+ concentration in the collecting duct Kidney Int. 1996. 50:S57-61

» DeCoy, DL, Snapper, JR, Breyer, MD Anti sense DNA down-regulates proteins kinase C-epsilon and enhances vasopressin-stimulated Na+ absorption in rabbit cortical collecting duct J Clin Invest 1995. 95:2749-56

» Sakairi, Y, Jacobson, HR, Noland, TD, Breyer, MD Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct Am J Physiol 1995. 269:F257-65

» Sakairi, Y, HR Jacobson, TD Noland, MD Breyer Luminal Prostaglandin E receptors regulate salt and water transport in the rabbit cortical collecting duct Am. J. Physiol. 1995. 269:F257-265

» DeCoy, DL, JR Snapper, MD Breyer Anti-sense DNA down-regulates protein kinase C-e and enhances vasopressin stimulated Na+ absorption in rabbit cortical collecting duct J. Clin. Invest 1995. 95:2749-2756

» Sakairi, Y, TD Noland, HR Jacobson, J Capdevila, JR Falck, and MD Breyer 5,6-Epoxyeicosatrienoic acid inhibits collecting duct ion transport via a cyclooxygenase-dependent mechanism coupled to PGE2 production Am. J. Physiol. 1995. 37:F931-995

» Ghishan, FK, S. Knobel, JA Barnard, MD Breyer Expression of a Novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney J. Membrane Biol. 1995. 144:267-271

» Burns, KD, J. Capdevila, S Wei, MD Breyer, T. Homma, R.C. Harris Role of cytochrome P-450 epoxygenase metabolites in EGF sginaling in renal proximal tubules Am. J. Physiol. Cell 1995. 269:C831-840

» Sakairi, Y, Jacobson, HR, Noland, TD, Capdevila, JH, Falck, JR, Breyer, MD 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis Am J Physiol 1995. 268:F931-9

» Breyer, RM, RB Emeson, MD Breyer, LS Davis, RM Abromson, SM Ferrenbach Alternative splicing generates multiple isoforms of the rabbit kidney prostaglandin E2 receptor J. Biol. Chem. 1994. 269:6163-6169

» Harris, RC, JA McKanna, Y. Akai, HR Jacobson, RN DuBois, and MD Breyer Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction J.Clin. Invest. 1994. 94:2504-2510

» Harris, RC, McKanna, JA, Akai, Y, Jacobson, HR, Dubois, RN, Breyer, MD Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction J Clin Invest 1994. 94:2504-10

» Furuya, H., Jacobson, HR, and Breyer, MD Evidence for basolateral membrane Ca++/H+ exchange in outer medullary collecting duct Am. J. Physiol. 1993. 264:F88-F93

» Takeda, M., T. Homma, MD Breyer, N. Horiba, RL Hoover, S Kawamoto, and V Kon Volume and agonist regulation of phosphorylation of myosin light chain in glomerular mesangial cells Am. J. Physiol. 1993. 264:F421-426

» Superdock, K.R., D. Snyders, M.D. Breyer An ATP-inhibited Cl- Channel in apical membanes of collecting duct Am.J. Physiol. 1993. 34:C957-65

» Hebert, RL, Jacobson, HR, and Breyer MD Evidence that separate prostaglandin receptors modulate water permeability and sodium transport in rabbit collecting duct Am. J. Physiol 1993. 265:F643-650

» Breyer, MD, HR Jacobson, LS Davis, and RM Breyer In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor Kidney Int. 1993. 43:1372-1378

» Breyer, MD, Jacobson, HR, Davis, LS, Breyer, RM In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor Kidney Int 1993. 44:1372-8

» Noland, T, Carter, C, Jacobson, HR, Breyer, MD PGE2 regulates cAMP generation in cultured rabbit cortical collecting duct cells: evidence for dual inhibitory pathways Am. J. Physiol. 1992. 263:C1208-1215

» Snyder, HM, Noland, T, and Breyer,MD Activation of cyclic AMP-dependent protein kinase mediates the hydroosmotic effect of vasopressin in the collecting duct Am. J. Physiol 1992. 263:C147-153

» Takeda, M., MD Breyer, TD Noland, T Homma, RL Hoover, T Inagami, and V. Kon Endothelin-1 receptor antagonist: Effects on endothelin and cyclosporine treated mesangial cells Kidney Int. 1992. 42:1713-1719

» Furuya, H.,MD Breyer, and HR Jacobson Functional characterization of a and b intercalated cell types in the rabbit cortical collecting duct Am. J. Physiol. 1991. 261:F377-385,

» Breyer MD Feedback inhibition of cAMP stimulated Na+ transport in the rabbit cortical collecting duct via Na+ dependent basolateral Ca++ influx J. Clin. Invest 1991. 88:1502-1510

» Burns, KD, Homma,T.Breyer, MD, Harris, RC Cytosolic acidification stimulates a calcium influx mechanism that activates Na+-H+ exchange in LLC-PK1 Am. J. Physiol. 1991. 261:F617-625

» H??bert, RL, Jacobson, HR, Breyer, MD Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium J Clin Invest 1991. 87:1992-8

» Snyder HM, Fredin, D., and Breyer MD Muscarinic receptor activation inhibits vasopressin stimulated water permeability in the rabbit cortical collecting duct Am. J. Physiol. 1991. 260:F929-F938

» Breyer, M.D Regulation of water and salt transport in collecting duct through calcium-dependent signaling mechanisms Am. J.Physiol. 1991. 260:F1-F11

» Hebert, RL, Jacobson, HR, and Breyer M.D Prostaglandin E2 inhibits sodium transport in the rabbit cortical collecting duct by increasing intracellular calcium J.Clin. Invest. 1991. 87:1992-1998

» H??bert, RL, Jacobson, HR, Breyer, MD PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation Am J Physiol 1990. 259:F318-25

» Breyer, MD, Redha, R, Breyer, JA Segmental distribution of epidermal growth factor binding sites in rabbit nephron Am J Physiol 1990. 259:F553-8

» Breyer MD, Redha R, Breyer JA Segmental distribution of epidermal growth factor binding sites in the rabbit nephron Am. J. Physiol. 1990. 259:F553-558

» Hebert RL, Jacobson HR, and Breyer MD PGE2 inhibits AVP induced water flow in cortical collecting ducts by protein kinase C activation Am J Physiol 1990. 259:F318-325

» Ando Y, Breyer MD, and Jacobson HR Dose dependent heterogeneous actions of vasopressin in rabbit cortical collecting ducts Am J Physiol 1989. 256:F556-F562

» Ando Y, Jacobson HR, and Breyer MD Phosphatidic acid inhibits the hydroosmotic effect of vasopressin in the collecting duct by activation of endogenous protein kinase C Am J Physiol 1989. 257:F524-F530

» Breyer MD and Jacobson HR Regulation of Medullary Collecting Duct Cell pH by Basolateral Na+/H+ and Cl-/Base Exchange J Clin Invest 1989. 84:996-1004

» Mesangial Cell, Glomerular and Renal Vascular Responses to Endothelin in Rat Kidney Badr KF, Murray JJ, Breyer MD, Takahashi K, Inagami T, Harris RC J Clin Invest 1989. 83:336-342

» Hirt D, Capdevila JH, Falck JR, Breyer MD and Jacobson HR Cytochrome P-450 metabolites of arachidonic acid are potent inhibitors of the action of vasopressin in rabbit cortical collecting duct J Clin Invest. 1989. 84:1805-1812

» Breyer MD. Jacobson HR, and Breyer JA Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule J Clin Invest 1988. 82:1313-1320

» Ando Y, Jacobson HR, and Breyer MD Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit collecting tubule J Clin Invest 1988. 81:1578-1584

» Ando Y, Jacobson HR, and Breyer MD Phorbol myristate acetate dioctanoyl-glycerol phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule J Clin Invest 1987. 80:590-593