Center for Matrix Biology - Vanderbilt University and Medical Center

Sergei Chetyrkin, Ph.D.
Research Instructor in the Department of Medicine - Nephrology

	Office Address:	MCN B 3121
	Mailing Address:	S-3223 Medical Center North 1161 21st Avenue South Nashville, TN 37232-2372
	Phone:	615-322-7729
	FAX:	615-343-7156
		email

Research Summary

We study post-Amadori reactions and mechanism(s) of inhibition of these reactions by pyridoxamine

Research Keywords

Protein glycation, Advanced Glycation End products (AGE), Pyridoxamine

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Associated initiative(s):

Diabetic Complications

Tissue Regeneration

Wound Repair

Selected Publications

» Chetyrkin SV, Belyaeva OV, Gough WH, Kedishvili NY. "Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties." J Biol Chem. 2001 Jun 22;276(25):22278-86. Epub 2001 Apr 09.

» Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY. "Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase." Arch Biochem Biophys. 2001 Feb 1;386(1):1-10.

» Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS. "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)." J Biol Chem. 2002 Aug 9;277(32):28909-15. Epub 2002 May 29.

» Belyaeva OV, Chetyrkin SV, Kedishvili NY. "Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4." Chem Biol Interact. 2003 Feb 1;143-144:279-87.

» Chetyrkin SV. "Transport and metabolism of vitamin A" Ukr Biokhim Zh. 2000 May-Jun;72(3):12-24. Review. Russian.

» Chetyrkin SV, Chernukhina LA, Porokhniak LA, Donchenko GV, Kuz'menko IV, Klimenko EP. "Effect of low doses of radiation on vitamin A and E levels in rat liver" Ukr Biokhim Zh. 1999 Mar-Apr;71(2):38-42. Russian.

» Chetyrkin SV, Chernukhina LA, Donchenko GV. "Retinol transport into the cell nucleus in vitro" Ukr Biokhim Zh. 1998 Mar-Apr;70(2):15-21. Russian.

» Chernukhina LA, Chetyrkin SV, Donchenko GV. "Interaction of the retinol-cellular-retinol-binding protein complex with nuclei of the glandular stomach mucosa cells in rooster" Ukr Biokhim Zh. 1993 Nov-Dec;65(6):71-5. Russian.

» Chetyrkin SV, Chernukhina LA, Donchenko GV. "Isolation of cellular retinol-binding protein from cattle liver" Ukr Biokhim Zh. 1993 May-Jun;65(3):105-7. Russian.

» S. V. Chetyrkin, D. Kim, J. M. Belmont, J. I. Scheinman, B. G. Hudson, and P. A. Voziyan. (2004) Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria, Kidney Int., in press.