Center for Matrix Biology - Vanderbilt University and Medical Center

Jeffrey M. Davidson, Ph.D.
Professor in the Department of Pathology

	Office Address:	C-3321A MCN
	Mailing Address:	21st Avenue C-3321A MCN Nashville, TN 37232-2562
	Lab address:	F404 ACRE, VA Medical Center
	Phone:	615-327-4751 ext. 5488
		email \| website

Research Summary

Elastin is a highly insoluble matrix protein with very low turnover. We study elastin gene expression in several biological systems. cDNA and antibody probes are used, respectively, to study regulation of elastin mRNA and protein synthesis, particularly related to modulation of elastin metabolism in diseases of human connective tissues such as blood vessels, lung and skin. Transcriptional and post-transcriptional regulation of matrix synthesis is evident in this system The role of mRNA stability, cis-acting mutations, and trans-acting factors are being evaluated in the context of elastic tissue diseases and growth factor responses. Cytokine effects are tested on cells from vascular smooth muscle, skin, and vocal fold. Several human diseases involve loss or excessive accumulation of elastic tissue, including an unusual aging syndrome, Hutchinson-Gilford progeria, and recessive and acquired forms of cutis laxa.. The consequences of elastin mutations that we discovered in cutis laxa is under intense examination

Connective tissue production and remodeling are also critical to proper wound repair. We have been examining the mechanisms of collagen and elastin turnover in pulmonary fibrosis and related diseases. We also use animal models to explore how addition or local inactivation of growth factors such as basic fibroblast growth factor, keratinocyte growth factor, transforming growth factor-? superfamily members, platelet derived growth factor and connective tissue growth affect the process and outcome of wound healing. Defective wound healing is an important clinical problem that is under study in fibrotic, aging and diabetic animal populations. Cellular and tissue-equivalent models are used where they appear to accurately reflect tissue behavior. Evaluation of gene expression by in situ and filter hybridization reveals diverse mechanisms, including the influence of metalloproteinases involved in reorganization of fibrous connective tissue.

We have used a novel form of gene therapy to express various factors in wounds with clear effects on the rate of healing. This technique offers the possibility of manipulating the healing process in a new and precise way, since recombinant expression vectors can be readily modified to understand structure-function relationships in an authentic biological context. Gene therapy of wounds also offers a rapid way to screen for wound healing functions of newly discovered cDNAs.

The laboratory is also part of the Vanderbilt Free-Electron Laser Center. This is a multidisciplinary program in which this laboratory is examining how tissues respond and heal after irradiation from the most powerful source of pulsed, infrared light energy in the country. .

Research Keywords

Pathology, Stem cells, Vascular Biology,

Printer Friendly

Associated initiative(s):

Angiogenesis

Biomaterials

Diabetic Complications

Fibrosis

Tissue Regeneration

Tumor Microenvironment

Wound Repair

Career opportunities:
None currently available

Selected Publications

» Davidson, JM First-class delivery: getting growth factors to their destination J Invest Dermatol 2008. 128:1360-2

» Prokop, A, Davidson, JM Nanovehicular intracellular delivery systems J Pharm Sci 2008. 97:3518-90

» Caldwell, RL, Opalenik, SR, Davidson, JM, Caprioli, RM, Nanney, LB Tissue profiling MALDI mass spectrometry reveals prominent calcium-binding proteins in the proteome of regenerative MRL mouse wounds Wound Repair Regen 2008. 16:442-9

» Hafeman, AE, Li, B, Yoshii, T, Zienkiewicz, K, Davidson, JM, Guelcher, SA Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration Pharm Res 2008. :

» Wilmink, GJ, Opalenik, SR, Beckham, JT, Abraham, AA, Nanney, LB, Mahadevan-Jansen, A, Davidson, JM, Jansen, ED Molecular Imaging-Assisted Optimization of Hsp70 Expression during Laser-Induced Thermal Preconditioning for Wound Repair Enhancement J Invest Dermatol 2008. :

» Rauth, TP, Poulose, BK, Davidson, JM, Nanney, LB, Holzman, MD Mechanical abrasion improves early incorporation of small intestinal submucosa Am Surg 2007. 73:647-51; discussion 651

» Hartig, SM, Greene, RR, Carlesso, G, Higginbotham, JN, Khan, WN, Prokop, A, Davidson, JM Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells Biomaterials 2007. 28:3843-55

» Hartig, SM, Carlesso, G, Davidson, JM, Prokop, A Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights Biomacromolecules 2007. 8:265-72

» Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM Novel approaches for understanding the mechanisms of wound repair J Investig Dermatol Symp Proc 2006. 11:132-9

» Davidson, JM, Giro, M Healing slack skin J Invest Dermatol 2006. 126:2563-4

» Tang, T, Shi, Y, Opalenik, SR, Brantley-Sieders, DM, Chen, J, Davidson, JM, Brandt, SJ Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes J Pathol 2006. 210:121-9

» Nanney, LB, Caldwell, RL, Pollins, AC, Cardwell, NL, Opalenik, SR, Davidson, JM Novel approaches for understanding the mechanisms of wound repair J Invest Dermatol 2006. 126 Suppl:132-9

» Samaras, SE, Shi, Y, Davidson, JM CARP: fishing for novel mechanisms of neovascularization J Investig Dermatol Symp Proc 2006. 11:124-31

» Spindler, KP, Murray, MM, Devin, C, Nanney, LB, Davidson, JM The central ACL defect as a model for failure of intra-articular healing J Orthop Res 2006. 24:401-406

» Wilmink, GJ, Opalenik, SR, Beckham, JT, Davidson, JM, Jansen, ED Assessing laser-tissue damage with bioluminescent imaging J Biomed Opt 2006. 11:041114

» Samaras, SE, Shi, Y, Davidson, JM CARP: Fishing for Novel Mechanisms of Neovascularization J Invest Dermatol 2006. 126 Suppl:124-31

» Opalenik, SR, Davidson, JM Fibroblast differentiation of bone marrow-derived cells during wound repair FASEB J 2005. 19:1561-3

» Carlesso, G, Kozlov, E, Prokop, A, Unutmaz, D, Davidson, JM Nanoparticulate system for efficient gene transfer into refractory cell targets Biomacromolecules 2005. 6:1185-92

» Shi, Y, Reitmaier, B, Regenbogen, J, Slowey, RM, Opalenik, SR, Wolf, E, Goppelt, A, Davidson, JM CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue Am J Pathol 2005. 166:303-12

» Wu, N, Davidson, JM Migration inhibitory factor-related protein (MRP)8 and MRP14 are differentially expressed in free-electron laser and scalpel incisions Wound Repair Regen 2004. 12:327-36

» Wu, Nanjun, Jansen, E Duco, Davidson, Jeffrey M Comparison of mouse matrix metalloproteinase 13 expression in free-electron laser and scalpel incisions during wound healing J Invest Dermatol 2003. 121:926-32

» Riordan, Colin L, McDonough, Mark, Davidson, Jeffrey M, Corley, Randall, Perlov, Cathy, Barton, Ronald, Guy, Jeffrey, Nanney, Lillian B Noncontact laser Doppler imaging in burn depth analysis of the extremities J Burn Care Rehabil 2003. 24:177-86

» Spindler, Kurt P, Murray, Martha M, Detwiler, Kenneth B, Tarter, Jeremy T, Dawson, John M, Nanney, Lillian B, Davidson, Jeffrey M The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament J Orthop Res 2003. 21:245-9

» Davidson, Jeffrey M, Breyer, Matthew D Inflammatory modulation and wound repair J Invest Dermatol 2003. 120:xi-xii

» Davidson, Jeffrey M, Eming, Sabine A, Dasgupta, Jayasri Particle-mediated gene therapy of wounds Methods Mol Med 2003. 78:433-52

» Ma, Li-Jun, Yang, Haichun, Gaspert, Ariana, Carlesso, Gianluca, Barty, Melissa M, Davidson, Jeffrey M, Sheppard, Dean, Fogo, Agnes B Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice Am J Pathol 2003. 163:1261-73

» Spindler, K P, Dawson, J M, Stahlman, G C, Davidson, J M, Nanney, L B Collagen expression and biomechanical response to human recombinant transforming growth factor beta (rhTGF-beta2) in the healing rabbit MCL J Orthop Res 2002. 20:318-24

» Wu, Nanjun, Opalenik, Susan, Liu, Jinhua, Jansen, E Duco, Giro, Maria Gabriella, Davidson, Jeffrey M Real-time visualization of MMP-13 promoter activity in transgenic mice Matrix Biol 2002. 21:149-61

» Davidson, Jeffrey M Smad about elastin regulation Am J Respir Cell Mol Biol 2002. 26:164-6

» Prokop, Ales, Kozlov, Evgenii, Moore, William, Davidson, Jeffrey M Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles J Pharm Sci 2002. 91:67-76

» Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B, Davidson, Jeffrey M, Linton, MacRae F, Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis J Clin Invest 2002. 110:1859-68

» Prokop, A., Kozlov, E., Moore, W. Davidson , J.M. Maximizing the in vivo efficiency of gene transfer by means of non-viral polymeric gene delivery vehicles. J Pharmaceut Sci, in press

» Ballas, C.B., Davidson, J.M Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations Wound Rep. Regen 2001. 9:223-227

» Davidson, J.M Experimental animal wound models Wounds 2001. 13:9-23

» Prokop, A., Kozlov, E., Nun Non, Shuhaida, Dikov, M.M., Sephel, G.C., Davidson, J.M Towards retrievable vascularized bioartificial pancreas (vbap): induction and long-lasting stability of polymeric mesh implant vascularized with help of acidic and basic fibroblast growth factors and hydrogel coating Diab Technol Therap 2001. 3:245-261

» Nanney LB, Wamil BD, Whitsitt J, Cardwell JL, Davidson JM, Yan, H.P., Hellerqvist CG CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism Angiogenesis 2001. 4:61-70

» Drew, A.F., Liu, H., Davidson, J.M., Daugherty, C.C., Degen, J.L Wound healing defects in mice lacking fibrinogen Blood 2001. 97:3691-98

» Nanney, L B, Wamil, B D, Whitsitt, J, Cardwell, N L, Davidson, J M, Yan, H P, Hellerqvist, C G CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism Angiogenesis 2001. 4:61-70

» Bennett, L L, Rosenblum, R S, Perlov, C, Davidson, J M, Barton, R M, Nanney, L B An in vivo comparison of topical agents on wound repair Plast Reconstr Surg 2001. 108:675-87

» Ballas, C B, Davidson, J M Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations Wound Repair Regen 2001. 9:223-37

» Davidson, J M, Krieg, T, Eming, S A Particle-mediated gene therapy of wounds Wound Repair Regen 2001. 8:452-9

» Prokop, A, Kozlov, E, Nun Non, S, Dikov, M M, Sephel, G C, Whitsitt, J S, Davidson, J M Towards retrievable vascularized bioartificial pancreas: induction and long-lasting stability of polymeric mesh implant vascularized with the help of acidic and basic fibroblast growth factors and hydrogel coating Diabetes Technol Ther 2001. 3:245-61

» Nanney, L.B., Paulsen, S., Davidson, M.K., Cardwell, N.L., Whitsitt, J.S., Davidson, J.M Boosting EGF receptor expression by gene gun transfection stimulates epidermal growth in vivo Wound Rep. Reg 2000. 8:117-127

» Ma, L J, Nakamura, S, Whitsitt, J S, Marcantoni, C, Davidson, J M, Fogo, A B Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1 Kidney Int 2000. 58:2425-36

» Nanney, L B, Paulsen, S, Davidson, M K, Cardwell, N L, Whitsitt, J S, Davidson, J M Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo Wound Repair Regen 2000. 8:117-27

» Ma, L.-J., Nakamura, S., Whitsitt, J.S., Marcantoni, C., Davidson, J.M., Fogo, A.B Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1 Kidney Int. 2000. 56:2425-2436

» Light, R.W., Cheng, D-S., Lee, Y.C., Rogers, J., Davidson, J.M., Lane, K.B A single intrapleural injection of transforming growth factor ?2 produces an excellent pleurodesis in rats Am J Respir Crit Care Med. 2000. 162:98-104

» Hoff, C.R. and Davidson, J.M Elastin expression in murine pulmonary fibrosis Connect. Tiss. Res 1999. 40:145-153

» Zhang, M.C., He L., Giro M, Yong S-L, Tiller G.E., and Davidson J.M Cutis laxa arising from frame shift mutations in the elastin gene (ELN) J. Biol. Chem 1999. 274:981-986

» Davidson, J.M., Aquino, A.M., Woodward, S.C., Wilfinger, W.W Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat FASEB J 1999. 13:325-329

» Eming, S.A., Whitsitt, J.S., He, L., Krieg, T., Morgan, J.R., Davidson, J.M Particle-mediated gene transfer of PDGF isoforms promotes wound repair J. Invest. Dermatol 1999. 112:297-302

» Davidson, J M, Whitsitt, J S, Pennington, B, Ballas, C B, Eming, S, Benn, S I Gene therapy of wounds with growth factors Curr Top Pathol 1999. 93:111-21

» Zhang, M C, He, L, Giro, M, Yong, S L, Tiller, G E, Davidson, J M Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN) J Biol Chem 1999. 274:981-6

» Garrard, C L, Clements, R H, Nanney, L, Davidson, J M, Richards, W O Adhesion formation is reduced after laparoscopic surgery Surg Endosc 1999. 13:10-3

» Davidson, J M, Aquino, A M, Woodward, S C, Wilfinger, W W Sustained microgravity reduces intrinsic wound healing and growth factor responses in the rat FASEB J 1999. 13:325-9

» Hoff, C R, Perkins, D R, Davidson, J M Elastin gene expression is upregulated during pulmonary fibrosis Connect Tissue Res 1999. 40:145-53

» Liaw, L., Birk, D.E., Whitsitt, J.S., Ballas, C.B., Davidson, J.M., Hogan, B.L.M Altered wound healing in mice lacking a functional osteopontin gene (spp1) J. Clin. Invest. 1998. 101:1468-1478

» Davidson, J.M Animal models for wound repair Arch. Dermatol Res 1998. 290:S1-S11

» Liaw, L, Birk, D E, Ballas, C B, Whitsitt, J S, Davidson, J M, Hogan, B L Altered wound healing in mice lacking a functional osteopontin gene (spp1) J Clin Invest 1998. 101:1468-78

» Davidson, J M Animal models for wound repair Arch Dermatol Res 1998. 290 Suppl:S1-11

» Davidson, J M Wound repair J Hand Ther 1998. 11:80-94

» Bryant, G L, Davidson, J M, Ossoff, R H, Garrett, C G, Reinisch, L Histologic study of oral mucosa wound healing: a comparison of a 6.0- to 6.8-micrometer pulsed laser and a carbon dioxide laser Laryngoscope 1998. 108:13-7

» Bryant, G.L., Davidson, J.M., Ossoff, R.H., Garrett, G. and Reinisch, L Histologic study of oral mucosa wound healing: A comparison of a 6.0- to 6.8-?m pulsed laser and a carbon dioxide laser Laryngoscope 1998. 108:13-17

» Davidson, J.M., Broadley, K.N., Quaglino Jr., D Reversal of the wound healing deficit in diabetic rats by combined basic fibroblast growth factor and transforming growth factor-? therapy Wound Rep. Regen 1997. 5:77-88

» Davidson, J.M., LuValle, P.A., Zoia, O., Quaglino, Jr., D., Giro, M.G Ascorbate down regulates collagen and elastin biosynthesis in vascular smooth muscle cells and skin fibroblasts by a pretranslational mechanism J. Biol. Chem 1997. 272:345-352

» Davidson, J M, LuValle, P A, Zoia, O, Quaglino, D, Giro, M Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms J Biol Chem 1997. 272:345-52

» Benn, S.I., Whitsitt, J.S., Broadley, K.N., He, L.,Nanney, L.B., Perkins, D, Patel, M., Swain, W.F.,Davidson, J.M Particle mediated gene transfer with TGF-?1 cDNAs enhances wound repair in rat skin J. Clin. Invest. 1996. 98:2894-2902

» Spindler, K.P., Imro, A.K., Mayes, C.E., Davidson, J.M Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor ? J. Orth. Res. 1996. 14:542-6

» Charous, SJ, Ossoff, RH, Reinisch, L, Davidson, JM Canine subglottic stenosis as a model for excessive fibrosis: a pilot histologic and immunohistochemical analysis Wound Repair Regen 1996. 4:444-53

» Clymer, M A, Schwaber, M K, Davidson, J M The effects of keratinocyte growth factor on healing of tympanic membrane perforations Laryngoscope 1996. 106:280-5

» Speyer, M, Joe, J, Davidson, J M, Ossoff, R H, Reinisch, L Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions Laryngoscope 1996. 106:845-50

» Spindler, K P, Imro, A K, Mayes, C E, Davidson, J M Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta J Orthop Res 1996. 14:542-6

» Spindler, K P, Clark, S W, Nanney, L B, Davidson, J M Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study J Orthop Res 1996. 14:857-61

» Benn, S I, Whitsitt, J S, Broadley, K N, Nanney, L B, Perkins, D, He, L, Patel, M, Morgan, J R, Swain, W F, Davidson, J M Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin J Clin Invest 1996. 98:2894-902

» Charous, S.J., Ossoff, R.H., Davidson, J.M Canine subglottic stenosis as a model for hypertrophic scarring: histological and immunochemical analysis Wound Repair Regen 1996. 4:444-453

» Clymer, M., Reinisch, L., Ossoff, R., Davidson, J.M Effects of keratinocyte growth factor on healing of tympanic membrane perforations Laryngoscope 1996. 106:280-285

» McCarthy, M.J., Davidson, J.M., Cardone, J.S., Anderson, L.L Cutis laxa aquisita associated with multiple myeloma: A case report and review of the literature Cutis 1996. 57:267-270

» Spindler, K.P., Clark, S.W., Nanney, L.B., Davidson, J.M Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study J. Orth. Res. 1996. 14:857-861

» Speyer, M., Joe, J., Davidson, J.M., Ossoff, R.H., Reinisch, L Thermal injury patterns and tensile strength of canine oral mucosa after carbon dioxide laser incisions Laryngoscope 1996. 106:845-850

» Spindler, KP, Nanney, LB, Davidson, JM Proliferative responses to platelet-derived growth factor in young and old rat patellar tendon Connect Tissue Res 1995. 31:171-7

» Broadley, C, Broadley, KN, Disimone, G, Riensch, L, Davidson, JM Low-energy helium-neon laser irradiation and the tensile strength of incisional wounds in the rat Wound Repair Regen 1995. 3:512-7

» Gossage, J R, Perkett, E A, Davidson, J M, Starcher, B C, Carmichael, D, Brigham, K L, Meyrick, B Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep J Appl Physiol 1995. 79:1163-72

» Broadley, C, Gonzalez, D A, Nair, R, Koriwchak, M J, Ossoff, R H, Davidson, J M A tissue-culture model for the study of canine vocal fold fibroblasts Laryngoscope 1995. 105:23-7

» TGF-? reverses a post-transcriptional defect of elastin synthesis in two cutis laxa skin fibroblast strains Zhang, M.C., Giro, M.G., Quaglino, D., Jr., Davidson, J.M J. Clin. Invest 1995. 95:986-994

» Zhang, M C, Giro, M, Quaglino, D, Davidson, J M Transforming growth factor-beta reverses a posttranscriptional defect in elastin synthesis in a cutis laxa skin fibroblast strain J Clin Invest 1995. 95:986-94

» Spindler, K P, Mayes, C E, Miller, R R, Imro, A K, Davidson, J M Regional mitogenic response of the meniscus to platelet-derived growth factor (PDGF-AB) J Orthop Res 1995. 13:201-7

» Davidson, J M, Zang, M C, Zoia, O, Giro, M G Regulation of elastin synthesis in pathological states Ciba Found Symp 1995. 192:81-94; discussion 94-9

» Vrabec, J T, Schwaber, M K, Davidson, J M, Clymer, M A Evaluation of basic fibroblast growth factor in tympanic membrane repair Laryngoscope 1994. 104:1059-64

» Tissue ablation by a free-electron laser tuned to the amide II band Edwards, G., Logan, R., Copeland, M., Reinisch, L., Davidson, J.M., Johnson, B., Maciunas, R., Mendenhall, M., Ossoff, R., Tribble, J., Werkhaven, J., O'Day, D Nature 1994. 371:416-419

» Kyzer, M D, Aly, A S, Davidson, J M, Reinisch, L, Ossoff, R H Sub ablation effects of the KTP laser on wound healing Lasers Surg Med 1993. 13:62-71

» Gossage, J R, Kuratomi, Y, Davidson, J M, Lefferts, P L, Snapper, J R Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep Am Rev Respir Dis 1993. 147:1371-9

» Giro, M, Davidson, J M Familial co-segregation of the elastin phenotype in skin fibroblasts from Hutchinson-Gilford progeria Mech Ageing Dev 1993. 70:163-36

» Lane, K B, Zoia, O, Davidson, J M Semidry electrophoretic transfer of RNA to membranes Biotechniques 1992. 12:340-2, 346

» Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease Am Rev Respir Dis 1992. 145:762-6

» Giro, M G, Duvic, M, Smith, L T, Kennedy, R, Rapini, R, Arnett, F C, Davidson, J M Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture J Invest Dermatol 1992. 99:129-37

» Perkett, E A, Davidson, J M, Meyrick, B Sequence of structural changes and elastin peptide release during vascular remodelling in sheep with chronic pulmonary hypertension induced by air embolization Am J Pathol 1991. 139:1319-32

» Henderson, G S, Conary, J T, Davidson, J M, Stewart, S J, House, F S, McCurley, T L A reliable method for northern blot analysis using synthetic oligonucleotide probes Biotechniques 1991. 10:190-7

» Fava, R A, Olsen, N J, Postlethwaite, A E, Broadley, K N, Davidson, J M, Nanney, L B, Lucas, C, Townes, A S Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia J Exp Med 1991. 173:1121-32

» Davidson, J M, Broadley, K N Manipulation of the wound-healing process with basic fibroblast growth factor Ann N Y Acad Sci 1991. 638:306-15

» Davidson, J M, Nanney, L B, Broadley, K N, Whitsett, J S, Aquino, A M, Beccaro, M, Rastrelli, A Hyaluronate derivatives and their application to wound healing: preliminary observations Clin Mater 1991. 8:171-7

» Quaglino, D, Nanney, L B, Ditesheim, J A, Davidson, J M Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin: incisional wound model J Invest Dermatol 1991. 97:34-42

» Davidson, J M Biochemistry and turnover of lung interstitium Eur Respir J 1990. 3:1048-63

» Garcia, F U, Wojta, J, Broadley, K N, Davidson, J M, Hoover, R L Bartonella bacilliformis stimulates endothelial cells in vitro and is angiogenic in vivo Am J Pathol 1990. 136:1125-35

» Quaglino, D, Nanney, L B, Kennedy, R, Davidson, J M Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model Lab Invest 1990. 63:307-19

» Buckley-Sturrock, A, Woodward, S C, Senior, R M, Griffin, G L, Klagsbrun, M, Davidson, J M Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors J Cell Physiol 1989. 138:70-8

» Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M The diabetic rat as an impaired wound healing model: stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor Biotechnol Ther 1989. 1:55-68

» Broadley, K N, Aquino, A M, Woodward, S C, Buckley-Sturrock, A, Sato, Y, Rifkin, D B, Davidson, J M Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair Lab Invest 1989. 61:571-5

» Liu, J M, Davidson, J M The elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells Biochem Biophys Res Commun 1988. 154:895-901

» Broadley, K N, Aquino, A M, Hicks, B, Ditesheim, J A, McGee, G S, Demetriou, A A, Woodward, S C, Davidson, J M Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats Int J Tissue React 1988. 10:345-53

» McGee, G S, Davidson, J M, Buckley, A, Sommer, A, Woodward, S C, Aquino, A M, Barbour, R, Demetriou, A A Recombinant basic fibroblast growth factor accelerates wound healing J Surg Res 1988. 45:145-53

» Sephel, G C, Sturrock, A, Giro, M G, Davidson, J M Increased elastin production by progeria skin fibroblasts is controlled by the steady-state levels of elastin mRNA J Invest Dermatol 1988. 90:643-7

» Buckley, A, Davidson, J M, Kamerath, C D, Woodward, S C Epidermal growth factor increases granulation tissue formation dose dependently J Surg Res 1987. 43:322-8