Conte Center

Vanderbilt / NIMH Silvio O. Conte Center for Neuroscience Research

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Vanderbilt University
465 21st Avenue South
Nashville, TN 37232
615-936-1898
For more information,
please contact Denise Malone.



Blakely Publications

P50MH096972, Project 3: Modeling The Serotonin Contribution to Autism Spectrum Disorders


Koshy Cherian, A., Parikh, V., Wu, Q., Mao-Drayer, Y., Blakely R.D., Sarter, M. Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transport capacity, Neurochem International, 2017 Sep;108:410-416. doi: 10.1016/j.neuint.2017.05.022. Epub 2017 May 31. PMID: 28577989


Simmler, L.D., Anacker, A.M.J., Levin, M.H, Vaswani, N., Gresch, P.J., Nackenoff, A.G, Anastasio, N.C., Stutz, S.J., Cunningham, K.A., Wang, J., Zhang, B., Henry, L.K., Veenstra-VanderWeele, J.,
Blakely, R.D. Serotonin transporter blockade contributes to the behavioral, neuronal and molecular effects of cocaine, British J. Pharmacol., in press. 2017 Jun 5. doi: 10.1111/bph.13899. [Epub ahead of print] PMID: 28585320


Brindley, R.L., Bauer, M.B.,
Blakely, R.D., and Currie, K.P.M. Serotonin and serotonin transporters in the adrenal medulla: A potential hub for modulation of the sympathetic stress response, ACS Chemical Neurosci, 2017 May 17;8(5):943-954. doi: 10.1021/acschemneuro.7b00026. Epub 2017 Apr 13.  PMID: 28406285


Robson, M.J., Quinlan, M.A.,
Blakely, R.D. Immune system activation and depression: Role of serotonin in the central nervous system and periphery, ACS Chemical Neurosci, 2017 May 17;8(5):932-942. doi: 10.1021/acschemneuro.6b00412. Epub 2017 Apr 3. PMID: 28345868


Nackenoff, A.G., Simmler, L.D., Baganz, N.L., Pehrson, A., Sánchez, C. and
Blakely, R.D. Serotonin transporter-independent actions of the antidepressant vortioxetine as revealed using the SERT Met172 mouse, ACS Chemical Neuroscience, 2017 May 17;8(5):1092-1100. doi: 10.1021/acschemneuro.7b00038. Epub 2017 Mar 20. PMID: 28272863


Siemann, J.K., Muller, C.L., Forsberg, C.G.,
Blakely, R. D., Veenstra-VanderWeele, J., Wallace, M.T. An autism-associated serotonin transporter variant disrupts multisensory processing, Translational Psychiatry, 2017 Mar 21;7(3):e1067. doi: 10.1038/tp.2017.17. PMID: 28323282 PMCID: PMC5416665


Koshy Cherian, A., Kucinski, A, Pitchers, L., Yegla, B., Parikh, V., Kim, Y., Valuskova, P., Gurnani, S., Lindsley, C.,
Blakely, R.D., Sarter, M.  Unresponsive choline transporter as a trait neuromarker and a causal mediator of bottom-up attentional biases, J Neurosci, 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13. PMID: 28193693 PMCID: PMC5354335


Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD,
Blakely RD, Bonnin A, Veenstra-VanderWeele J. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology. 2017 Jan;42(2):427-436. doi: 10.1038/npp.2016.166. Epub 2016 Aug 23. PMID: 27550733 DOI: 10.1038/npp.2016.166. [PubMed - in process]


Brindley RL, Bauer MB, Blakely RD, Currie KP. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. 2016 Nov;110(Pt A):438-48. doi: 10.1016/j.neuropharm.2016.08.015. Epub 2016 Aug 18. PMID: 27544824 PMCID: PMC5028315 [Available on 2017-11-01] DOI: 10.1016/j.neuropharm.2016.08.015


Bermingham DP,
Blakely RD. Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Pharmacol Rev. 2016 Oct;68(4):888-953. doi: 10.1124/pr.115.012260. PMID: 27591044 PMCID: PMC5050440 [Available on 2017-10-01] DOI: 10.1124/pr.115.012260.


Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J,
Blakely RD, Gershon MD. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25. PMID: 27111230 PMCID: PMC4887174.


Robson MJ, Zhu CB, Quinlan MA, Botschner DA, Baganz NL, Lindler KM, Thome JG, Hewlett WA,
Blakely RD. Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. PLoS One. 2016 Mar 1;11(3):e0150068. doi: 10.1371/journal.pone.0150068. eCollection 2016. PMID: 26930558 PMCID: PMC4773179.


Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H,
Deneris ES, Hewlett WA, Blakely RD. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Transl Psychiatry. 2015 Nov 3;5:e671. doi: 10.1038/tp.2015.168. PubMed PMID: 26529424. PMCID: PMC5068761.


Chen X, Ye R, Gargus JJ,
Blakely RD, Dobrenis K, Sze JY. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01062-6. doi: 10.1016/j.celrep.2014.12.033. [Epub ahead of print] PubMed PMID: 25600870. PMCID: PMC4824665.


Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C,
Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry. 2015 Feb;20(1):118-25. doi: 10.1038/mp.2014.98. Epub 2014 Sep 9. PubMed PMID: 25199916; PubMed Central PMCID: PMC4426202.


Rudnick G, Krämer R,
Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan;466(1):25-42. doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13. Review. PubMed PMID: 24337881; PubMed Central PMCID: PMC3930102.


Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B,
Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 2014 Mar;13(3):247-60. doi: 10.1111/gbb.12092. Epub 2013 Oct 31. PubMed PMID: 24102824; PubMed Central PMCID: PMC3979832.


Baganz NL,
Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci. 2013 Jan 16;4(1):48-63. doi: 10.1021/cn300186b. Epub 2012 Dec 7. Review. PubMed PMID: 23336044; PubMed Central PMCID: PMC3547518.


Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AM, Piston DW,
Blakely RD, Rosenthal SJ. Single molecule analysis of serotonin transporter regulation using antagonist conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. J Neurosci. 2012 Jun 27;32(26):8919-29. doi: 10.1523/JNEUROSCI.0048 12.2012. PubMed PMID: 22745492; PubMed Central PMCID: PMC3426861.