Figure A, Segmental organization of the genital disc showing A8, A9 and A10 segments with their anterior (a, light colours) and posterior (p, dark colours) compartments. L, lumen. Excerpted from "Type ID unconventional myosin controls left-right asymmetry in Drosophila."
Cross-section of a cilia

Shown are confocal images of ciliated cells after labelling basal bodies with a Centrin2–GFP fusion protein (green) and staining for actin with rhodamine-phalloidin (red).  Excerpted from "A positive feedback mechanism governs the polarity and moton of motile cilia."


 

Matt Tyska, Ph.D. (Organizer and Instructor )
Assistant Professor - Cell and Developmental Biology 

Byeong Cha, Ph.D. (Organizer and Instructor) 
Assistant Professor - Cell and Developmental Biology

(For more information about CBIO341 please contact the Course Coordinator)

There are two books for this course that are highly recommended:  Principles of Development by Lewis Wolpert, and Developmental Biology by Scott F. Gilbert.  

Click on the appropriate module name for class specifics by date.

Class Date
Topics, Presentations & Readings
2/14/08 The cytoskeleton as a molecular template for polarizing cells and tissues
2/21/08 Actin-based transport
  Research Articles
    An unconventional myosin in Drosophila reverses the default handedness in visceral organs.
2006 Nature 440: 798-802
    Type ID unconventional myosin controls left-right asymmetry in Drosophila. 
2006 Nature 440, 803-807
  Reviews
    Left-right asymmetry: class 1 myosins show the direction. 
2007 Current Opinion in Cell Biology 19, 82-87
    Left-right asymmetry: actin-myosin through the looking glass.
200`6 Current Biology 16: R502-504
    Strategies to establish left/right asymmetry in vertebrates and invertebrates.
2007 Current Opinions in Gentic Development 17, 351-358
2/26/08 Microtubule-based transport
  Research Articles
    Centrosome localization determines neuronal polarity. 
2005 Nature 436, 704-708
    Differential regulation of Dynein and Kinesin motor proteins by Tau.
2008 Science [published online January 17, 2008]
    Microtubule acetylation promotes kinesin-1 binding and transport.
 2006 Current Biology 16, 2166-2172
  Reviews
    Key regulators in neuronal polarity.
2005 Neuron 48, 881-884
    Microtubules and neuronal polarity: lessons from mitosis.
1999 Neuron 22, 23-31
    Molecular motors and mechanisms of directional transport in neurons.
 2005 Nature Reviews Neuroscience 6, 201-204
    The tubulin code.
2007 Cell Cycle 6, 2152-2160
2/28/08 Cilia and intraflagellar transport
    Intraflageller transport particles participate directly in ciliun-generated signaling in Chlamydomonas. 
2006 Cell 125; 549-562
    The graded response to Sonic Hedgehog depends on cilia architecture. 
2007 Dev Cell 12: 767-778
    Hedgehog signalling in the mouse requires intraflagellar transport proteins. 
2003 Nature 426: 83-87
  Reviews
    Intraflagellar transport. 
2002 Nat Rev Mol Cell Biol 3: 813-825
    Cilia and developmental signaling. 
2007 Annu Rev Cell Dev Biol 23: 345-373
    Intraflagellar transport and cilium-based signaling. 
2006 Cell 125: 439-442
    Making sense of cilia and flagella. 
2007 J Cell Biol 179: 575-582
3/4/08 Student-led Paper Discussion (moderated by Russell McConnell)
    Inositol polyphosphates regulate zebrafish left-right asymmetry. 
2005 Dev Cell 9: 133-145
    A role for insitol kinase lpk1 in ciliary beating and length maintenance. 
2007 PNAS 104: 19843-19848
3/6/08 Student-led Invited Guest Paper Discussion (moderated by: TBA)
    A positive feedback mechanism governs the polarity and moton of motile cilia. 
2007 Nature 447: 97-101
    Cilia orientation and the fluid mechanics of development. 
2008 Curr Opin Cell Biol 20: 48-52
3/11/08 Internal Guest Speaker Seminar w/ Bhaskarjyoti Sarmah, Ph.D.
Postdoctoral Fellow, Ssan Wente Lab, Cell and Developmental Biology
3/13/08 Invited Guest Speaker - Christopher Kintner, Ph.D.
Developmental Physiology of Ciliated Epithelia
 
The Module 2 Exam will be distributed on March 13, 2008 and is
DUE by March 20, 2008
 

 

  

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 Last modified: Wednesday, March 5, 2008 by Kim.Kane@vanderbilt.edu