Cancer and Embryonic Development meets every Monday, Wednesday, and Friday from 2:30 to 3:30 pm in 3131 MRBIII.   We will have three graduate trainees and one postdoctoral fellow serving as teaching assistants and with their help will provide students with highly interactive, student-teacher environment.  This year, the course will be divided into 4 modules. 

The fourth module, Regulatory Pathways, will be offered from Monday, March 23 through Friday, April 17, 2009.  Presentations and readings for each class follow.

To download the presentation from each class simply click on the title.  Clicking on a reading will either take you to the webpage for the full article or pdf download or allow you to download the publication directly (in cases where the information is not available on the web).

IV. REGULATORY PATHWAYS
3/23/09	Volker Haase	Hypoxic signaling in development and injury
Reading	Direct regulation of TWIST by HIF-1alpha promotes metastasis.  2008 Nature Cell Biology 10; 295-305
Readingl	A hypoxic twist in metastasis.  2008 Nature Cell Biology 10: 253-254
3/25/09	Mohamed Hassanein	Hypoxic signaling in cancer
Reading	Hypoxia and low-nutrition double stress induces aggressiveness in a murine model of melanoma.  2009 Cancer Science [Epub ahead of print]
3/27/09	Students	Journal Club
3/30/09	Maureen Gannon	Cell cycle control in development
Reading	Loss of Cdk4 expression causes insulin deficient diabetes and Cdk4 activitation results in beta-islet cell hyperplasia.  1999 Nature Genetics 44-52
4/1/09	Sandra Zinkel	Cell cycle control in cancer
Reading	Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice.  2007 Cancer Cell 11: 9-23
Reading	Aneuploidy: Instigator and Inhibitor of Tumorigenesis.  2007 Cancer Research 67: 10103- 10105
4/3/09	Students	Journal Club
4/6/09	Alex Meissner  GUEST	Pluipotency and epigenetics in organ development
Reading	Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.  2007 Nature 448: 553- 560
Reading	Dissecting direct reprogramming through integrative genomic anaylsis.  2008 Nature 454: 49-55
Reading	Genome-scale DNA methylation maps of pluripotent and differentiated cells.  2008 Nature 454: 766-770
4/8/09	Thomas Andl	Epigenetic silencing in cancer
Reading
4/11/09	Students	Journal Club
4/13/09	Jim Patton	MicroRNAs in development
Reading	MicroRNA control of Nodal signalling.  2007 Nature 449: 183
4/15/09	Michael Thomason	MicroRNAs in cancer
Reading	A microRNA polycistron as a potential human oncogene.  2005 Nature 435: 828-833
4/17/09	Students	Journal Club
4/20/09	Mark deCaestecker	FEEDBACK
(For more information about CBIO320/CANB320 please contact the Course Director or Course Assistants)