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is a three hour, dual Cancer Biology and Cell and Developmental Biology accredited course that is open to first and second year graduate students at Vanderbilt, Meharry, and Fisk Universities. There are no specific prerequisites for Cancer and Embryonic Development, although some knowledge of biological systems and pathways would be useful. The course was conceived as an opportunity to expose students to the different conceptual frameworks and approaches used by developmental and cancer biologists to study common biological responses and pathways used during normal embryonic development and malignancy.
In addition to Andrea Page-McCaw, Ph.D. and Ethan Lee, M.D., Ph.D. (Course Directors) there will be four teaching assistants: Eric Bankaitis (GS-Cell and Developmental Biology), Annie Powell, Ph.D. (PD-Cancer Biology), Laura Hover (GS, Cancer Biology) and Spencer Crowder (GS-affiliation TBA). With their help, you will be part of a highly interactive, student-teacher environment.
- You can obtain more information about each topic instructor by clicking on their name
- You can obtain each Powerpoint presentation by clicking on the topic title
| Class will meet in 3131 MRBIII every Monday, Wednesday and Friday from 2:30 to 3:30 pm | ||
| DATE | TOPIC & INSTRUCTOR | |
| 1/11/13 | Introduction | |
| WEEK 1 - STRUCTURAL FRAMEWORKS | ||
| 1/14/13 | Germ layers and organogenesis available | |
| David Bader, P.hD. | ||
| 1/16/13 | Cancer progression available | |
| Rebecca Cook, Ph.D. | ||
The microenvironment in breast cancer progression: biology and implications for treatment 2011 Breast Cancer Research 13: 227 |
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| 1/18/13 | Journal Club 1available | |
| WEEK 2 - CELL MOVEMENT | ||
| 1/21/13 | Physics in cell migration available | |
| Erin Rericha, Ph.D. | ||
New dimensions in cell migration 2012 Nature Reviews/Molecualr Cell Biology 13: 743-747 |
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| 1/23/13 | Cell movement available | |
| Florent Elefteriou, Ph.D. | ||
Beta-adrenergic blocking drugs in breast cancer: a perspective review 2012 Therapeutic Advances in Medical Oncology 4: 113-125 |
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| 1/25/13 | Journal Club 2 available | |
| WEEK 3 - NEURAL CREST SPECIFICATION | ||
| 1/28/13 | Neural crest specification available | |
| Brian Nelms, Ph.D. | ||
Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration 2012 Developmental Biology 366: 34-54 |
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| 1/30/13 | Neural crest tumors: neuroblastoma available | |
| Dai H. Chung, M.D. | ||
| 2/01/13 | Journal Club 3 Guest Speaker Rafi Kopan Papers available | |
| WEEK 4 - CELL ECM INTERACTIONS | ||
| 2/04/13 | Molecular mechanisms of developmental glomerular disease related to cell-ECM interactions available | |
| Roy Zent, Ph.D. | ||
Integrins in renal development 2012 Pediatric Nephrology 27: 891-900 Cell-matrix adhesion of podocytes in physiology and disease 2013 Nature Reviews/Nephrology January 22 |
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| 20/6/13 | ||
| Raphael Kopan, Ph.D. | ||
The canonical Notch signaling pathway: unfolding the activation mechanism 2009 Cell 137: 216-233 |
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| 2/08/13 | The role of extracellular matrix in tumorigenesis available | |
| Ambra Pozzi, Ph.D. | ||
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. 2012 Nature Communications 3: 1122 |
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| WEEK 5 - ANGIOGENESIS | ||
| 2/11/13 | Developmental neovascularization available | |
| John Penn, Ph.D. | ||
2000 Placenta 21: S11-S15 |
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| 2/13/13 | Angiogenesis in cancer available | |
| Pampee Young,M.D., Ph.D. | ||
Tumor angiogenesis: molecular pathways and therapeutic targets 2011 Nature Medicine 17: 1359-1370 |
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| 2/15/13 | Journal Club 5 Guest Speaker David Sherwood Papers available | |
| WEEK 6 - INVASION | ||
| 2/18/13 | Breaching the basement membrane: anchor cell invasion in C. elegans | |
| David Sherwood, Ph.D. (Duke University) | ||
Cell inaction through basement membrane: the anchor cell breaches the barrier. 2011 Current Opinion in Cell Biology 23: 589-596 |
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| 2/20/13 | Cancer invasion available | |
| Alissa Weaver,MD, Ph.D | ||
Directed cell invasion and migration during metastasis. 2012 Current Opinion in Cell Biology 24: 277-283 |
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| 2/22/13 | Journal Club 6 available | |
| WEEK 7 - HEDGEHOG SIGNALING & THE BRAIN | ||
| 2/25/13 | Hedgehog signaling in brain development available | |
| Jonathan Fleming, B.S. | ||
| (you may skim this article since it is so large) Hedgehog signaling in animal development: paradigms and principles. 2001 Genes & Development 15: 3059-3087 |
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| 2/27/13 | Hedgehog signaling in cancer available | |
| Michael Cooper, M.D. | ||
| Recommended Reading Targeting the Hedgehog pathway in cancer. 2006 Nature Reviews Drug Discovery 5: 1026-1033 |
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| 3/01/13 | Journal Club 7 available | |
| WEEK 8 - EPIGENETICS | ||
| 3/11/13 | The role of epigeentic mechanisms during development available | |
| Sebastian Rieck, Ph.D. | ||
| Recommended Reading Control of the embryonic stem cell state 2011 Cell 144: 940-957 |
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| 3/13/13 | Epigenetics and cancer available | |
| Wael El-Rifai,M.D., Ph.D. | ||
| Recommended Reading A decade of exploring the cancer epigenome - biological and translational implications 2011 Nature Reviews Cancer 11: 726-734 |
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| 3/15/13 | Journal Club 8 available | |
| WEEK 9 - NOTCH | ||
| 3/18/13 | No Class See 2/6/13 Rafi Kopan Seminar | |
| 3/20/13 | TBA | |
| Stacey Huppert, Ph.D. | ||
| Recommended Readings Notch signaling: simplicity in design, versatility in function 2011 Development 138: 3593-3612 The double-edged sword of Notch signaling in canc2013cbio320wk7devbiolectureer 2012 Seminars in Cell & Developmental Biology 23: 458-464 |
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| 3/22/13 | Journal Club 9 available | |
| WEEK 10 - BMP | ||
| 3/25/13 | Spatial regulation of BMP signaling during embryonic development available |
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| Mark deCaestecker,M.D., Ph.D. | ||
Recommended Readings |
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| 3/27/13 | Bone Morphogenetic Proteins (BMPs) in Cancer: lessons from embryology available |
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| Phil Owens, Ph.D. | ||
| Recommended Readings Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? 2010 Endocrine-Related Cancer 17: R123-R139 |
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| 3/29/13 | Journal Club 10 Guest Speaker Xi He Papers available | |
| WEEK 11 - WNT | ||
| 4/01/13 | Understanding Wnt Signaling in Development and Disease | |
| Xi He, Ph.D. (Harvard Medical School) | ||
| Recommended Reading Wnt/Beta-Catenin signaling: components, mechanisms, and diseases 2009 Developmental Cell 17: 9-26 |
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| 4/03/13 | TBA | |
| Bob Coffey, M.D. | ||
| Recommended Reading Wnt signaling, stem cells, and cancer of the gastrointestinal tract. 2012 Cold Spring Harbor Perspectives in Biology |
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| 4/05/13 | Journal Club 11 available | |
| WEEK 12 -mTOR | ||
| 4/08/13 | There will be blood: Mammalian target of Rapamycin (mTOR) pathways in hematopoietic development and bloody cancers Presentation not available at PI's request | |
| Mark Boothby, M.D., Ph.D. | ||
| Recommended Reading mTOR signaling in growth control and disease 2012 Cell 149: 274-293 |
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| 4/10/13 | mTOR on the brain: neurodevelopment and brain tumors available | |
| Kevin Ess, M.D., Ph.D. | ||
| Recommended Reading mTOR signaling in growth control and disease 2012 Cell 149: 274-293 |
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| 4/12/13 | Journal Club 12 available | |
| WEEK 13 - SCREENING | ||
| 4/15/13 | TBA | |
| David Miller, Ph.D. | ||
The art and design of genetic screens: Caernorhabditis elegans 2002 Nature Reviews Genetics 3: 356-369 |
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| 4/17/13 | TBA | |
| Charles Hong, M.D., Ph.D. | ||
| 4/19/13 | Journal Club 13 | |
| WEEK 14 - FEEDBACK | ||
| 4/22/13 | Feedback | |
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Last modified: Tuesday, April 16, 2013 by
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