On Fridays, Cancer and Embryonic Development classes are dedicated to the student-led journal club. Succinct papers will be chosen in advance by the course instructors for their ability to illustrate and elucidate the links between cancer and embryonic development.  Background information on each paper will be provided in advance, so that students can focus their efforts on the paper itself. 

In preparing for their talk, students should focus on the most important aspects of the paper and highlight the similarities and differences between the two disciplines.  Presentations should be 15-minutes in length, followed by an ~12-minute discussion period.  The instructors for the week will be present to address any questions that the student presenters are unable to answer. These talks will NOT be graded but each student will be given personal feedback afterwards.

In addition to Andrea Page-McCaw, Ph.D. and Ethan Lee. M.D., Ph.D. (Course Directors) there will be four teaching assistants: Eric Bankaitis (GS-Cell and Developmental Biology), Annie Powell, Ph.D. (PD-Cancer Biology), Laura Hover (GS, Cancer Biology) and Spencer Crowder (GS-affiliation TBA). With their help, you will be able to present and discuss relevant papers with confidence.

• Click on the paper of your choice to download the reading material

Class will meet in 3131 MRBIII every Monday, Wednesday and Friday from 2:30 to 3:30 pm
WEEK 1 - STRUCTURAL FRAMEWORK
1/18/13	Paper #1 - S. Connonier Development of the chick embryo mesoblast: pronephros, lateral plate, and early vasculature. S. Meier (1980) J. Embryol. exp. Morph 155; 291-306 pdf download available
1/18/13	Paper #2 - R. Rath Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch. J.M. Haughian et al (2012) PNAS 109: 2742-2747 available
WEEK 2 - CELL MOVEMENT
1/25/13	Paper #3 - B. Jones Arp2/3 is critical for Lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis C Wu et al (2012) Cell 148: 973-987 available
1/25/13	Paper #4 - N. MacDonald Tumour-infitrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling W. Tan et al (2011) Nature 470: 548-553 available
WEEK 3 - NEURAL CREST SPECIFICATION
2/01/13	Paper #5 - W. Lewis Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin S. Demehri et al (2012) Cancer Cell 22: 494-505 available
2/01/13	Paper #6 - A. Andrews Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity S. Demehri et al (2008) PLoS Biology 6: e123 available
WEEK 4 - CELL-ECM INTERACTIONS
2/08/13	There are no Journal Club papers or presentations due this week
WEEK 5 - ANGIOGENESIS
2/15/13	Paper #7 - M. Sowder In vivo identification of regulators of cell invasion across basement membranes D.Q. Matus et al. (2010) Cell Biology 3: ra35: 1-9 available
2/15/13	Paper #8 - H. Loomans Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans S. Ihara et al. (2010) Nature Cell Biology 13: 641 - 651 available
WEEK 6 - INVASION
2/22/13	Paper #9 - S. Connonier, E. Tross, and W. Lewis Twist1-induced Invadopodia formation promotes tumor metastasis. M.A. Eckert et al (2011) Cancer Cell 19: 372-386 available
WEEK 7 - HEDGEHOG SIGNALING & THE BRAIN
3/01/13	Paper #10 - Z. Elmore Nerve-derived Sonic Hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells I. Brownell et al (2011) Cell Stem Cell 8: 552-565 available
3/01/13	Paper #11 - S. Winters and R. Rath Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. E. Petrova et al (2013) Nature Chemical Biology 17 February download available
WEEK 8 - EPIGENETICS
3/15/13	Paper #12 - E. Tross Chromatin "Prepattern" and histone modifiers in a fate choice for liver and pancreas C-R Xu et al (2011) Science 332: 963- 966 available Supplemental Figures, Materials & Methods available
3/15/13	Paper #13 - M. Sowder and B. Jones Regional activation of the cancer genome by long-range epigenetic remodeling S.A. Bert et al - 2013 Cancer Cell 23: 9-22 available
WEEK 9 - NOTCH SIGNALING
3/22/13	Paper #14 - N. MacDonald, H. Loomans, and Z. Elmore Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma K.A. Hassan et al - 2013 Clinical Cancer Research Feb 11 available
WEEK 10 - BMP
3/29/13	Paper #15 - S. Winters Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. X. Zhang et al - 2012 Cell 149: 1565-1577 available
3/29/13	Paper #16 - A. Bradley and M. Williams Kinetic responses of beat-catenin specify the sites of Wnt control. A. Hernandez et al - 2012 Science 338: 1337 available
WEEK 11 - WNT
4/05/13	Paper #17 - A. Andrews, A. Willet, and J. Evans HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation. 2013 Journal of Biological Chemistry 288: 8289-8298 available
WEEK 12 - mTOR
4/12/13	Paper # 18 - A. Bradley mTOR Complex 1 plays critical roles in hematopoiesis and Pten-Loss-Evoked leukemogenesis 2012 Cell Stem Cell 11: 429-439 available
4/12/13	Paper # 19 - J. Evans Rapamycin inhibits the growth of glioblastoma A. Arcella et al - 2013 Brain Research 1495: 37-51 available
WEEK 13 - SCREENING
4/19/13	Paper #20 - M. Williams Programmed elimination of cells by caspase-independent cell extrusion in C. elegans D. P. Denning et al - 2012 Nature 488: 226 - 230 available
4/19/13	Paper #21 - A. Willet Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions 2003 PNAS 100: 4616-4621 available