The Chiang lab's research is focused on Sonic hedgehog (Shh) signaling in development and cancer.  They study how the distribution of Shh protein is regulated and how this regulation affects the identity and number of neural progenitors/stem cells in the central nervous system.  The lab uses the vertebrate system to address these questions, with emphasis on neural progenitors involved in the establishment of the brain circuitry or the generation of tumors.

RECENT PUBLICATIONS

Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.   2009 Development 136: 2535-2543

Shh and Gli3 activities are required for timely generation of motor neuron progenitors.  2009 Developmental Biology 331: 261-269