Phone 615.936.5574
Office 4270 MRBIII
Nashville, TN 37232-1634
Email josh.gamse@vanderbilt.edu

Figure 4. The asymmetic zebrafisg habenular nuclei are central to the dorsal diencephalic conduction pathway. Excerpted from "Making a difference together: reciprocal interactions in C. elegans and zebrafisg asymmetric neural development."


 

Left-right differences in the adult human brain have been noted for over 150 years. However, the way in which brain asymmetry is established during fetal development is not well understood. Reduced or reversed brain asymmetry have been linked to many psychiatric disorders, including schizophrenia, autism, depression, and dyslexia.

The Gamse laboratory is identifying and studying genes that control how such left-right asymmetries develop in the vertebrate brain. They use the zebrafish as a model organism for these studies. Zebrafish embryos have many advantages for investigating brain laterality, as they are transparent, develop rapidly, and have prominent left-right differences in the brain, particularly in a region known as the epithalamus. Gamse lab members have identified genes that control the formation of brain asymmetry by looking for mutant versions of these genes that cause defects in epithalamic laterality. These genes, and the consequences of their mutation, have revealed a series of embryonic events that lead to left-right asymmetry. These include migration of neurons from the center of the brain towards one side, and elaboration of different neuronal morphology on the left versus the right side. The lab is continuing to identify new laterality genes through forward and reverse genetic methods, in an effort to comprehensively describe the formation of asymmetry in the epithalamus.

 

NEWEST PUBLICATIONS

Making a difference together: reciprocal interactions in C. elegans and zebrafisg asymmetric neural development.
2010 Development 137: 681-691

Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development.
2009 PNAS 106: 2023-2028

 

PREVIOUS PUBLICATIONS

For more information about Dr. Gamse visit his Vanderbilt Faculty or Lab Web Pages
 

 

 

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Copyright 2004, Educational Technology, Biomedical Research Education & Training
Last modified: Monday ,October 25, 2010 by Kim.Kane@vanderbilt.edu