The differences between the right and left sides of the brain are widely known, such as the localization of language functions to the left cerebral hemisphere in most people. However, the developmental processes in the brain responsible for left-right (L/R) asymmetry are not well understood. The Gamse laboratory studies this question in zebrafish because of the molecular, genetic, and embryological techniques it makes available. The lab's attention is currently focused on the epithalamus, a brain region that exhibits dramatic L/R asymmetry in many lower vertebrates. Lab members have identified three closely related genes that show asymmetric expression in the epithalamus. Since their function is unknown, the Gamse lab is performing functional knockdowns on these genes. Gamse lab members have also performed a genetic screen to identify brain asymmetry mutants. One mutant lacks asymmetric features in the epithalamus, but laterality of the visceral organs (including pancreas, gall bladder, and liver) is normal. Lab members are working to determine the identity of this presumptive brain-specific laterality gene.

For more information about Dr. Gamse visit his Vanderbilt Faculty Page

NEWEST PUBLICATIONS

Tbx2b is required for the development of the parapineal organ.   Development (2008) 135: 1693-1702

Selective asymmetry in a conserved forebrain to midbrain projection.  Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (2007) 308B: 669-678