The Broadie Lab works on nervous system development, including neuronal pathfinding, target recognition and synaptogenesis. Lab members take a genetic approach in Drosophila, using mutagenesis screens to identify developmental mutants, and a combination of light imaging, electron microscope ultrastructural studies and electrophysiology to characterize mutant phenotypes. Trainees in the Broadie lab typically take one of two courses; 1) molecular genetics training in the mutagenesis, mapping, cloning and transgenic manipulation of target genes, or 2) cellular neurobiology training in confocal imaging and functional neurobiological techniques to assay mutant phenotypes. Motivated students pursue both courses in parallel.

For more information about Dr. Broadie visit his Vanderbilt Faculty Page or his Lab Website

NEWEST PUBLICATIONS

Harvesting and preparing Drosophila embryos for electrophysiological recording and other procedures.  2009 Journal of Visualized Experiments 20

Electrophysiological recording in the Drosophila embryo.  2009 Journal of Visualized Experiments 21

Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments.  2009 Developmental Dynamics 238: 554-571

The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation.  2009 Molecular Neurobiology [Epub ahead of print]

Rolling blackout is required for bulk endocytosis in non-neuronal cells and neuronal synapses.  2009 Journal of Cell Science 122: 1140-125.