The Broadie Lab works on nervous system development, including neuronal pathfinding, target recognition and synaptogenesis. Lab members take a genetic approach in Drosophila, using mutagenesis screens to identify developmental mutants, and a combination of light imaging, electron microscope ultrastructural studies and electrophysiology to characterize mutant phenotypes. Trainees in the Broadie lab typically take one of two courses; 1) molecular genetics training in the mutagenesis, mapping, cloning and transgenic manipulation of target genes, or 2) cellular neurobiology training in confocal imaging and functional neurobiological techniques to assay mutant phenotypes. Motivated students pursue both courses in parallel.

For more information about Dr. Broadie visit his Vanderbilt Faculty Page or his Lab Website

NEWEST PUBLICATIONS

Proteasome function is required to maintain muscle cellular architecture.  2007 Biol Cell. May 24; [Epub ahead of print]

The ubiquitin–proteasome system postsynaptically regulates glutamatergic synaptic function.  2007 Molecular and Cellular Neuroscience (Article in Press)

In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila.  2007 Journal of Neuroscience 162: 198-205