The Cooper laboratory studies molecular signaling pathways in the developing nervous system. Lab members are interested in learning how extracellular signals are generated, received and implemented to coordinate cellular growth and differentiation during neural development. Sonic hedgehog (Shh) is the best characterized of three vertebrate Hedgehog signaling proteins and is of considerable interest because of its role in regulating progenitor cells during tissue patterning, regeneration and malignant transformation. The lab's current research efforts are directed at understanding the molecular events through which Shh signaling influences dopaminergic neurogenesis in the midbrain, regulates progenitor cell proliferation in adult gliomas, and how lipid modifications govern the spatial deployment of Shh ligand within the neuroepithelium.

For more information about Dr.Cooper visit his Vanderbilt Faculty Page or his Lab Website

NEWEST PUBLICATIONS

Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells.  Oncogene ePublication March 12, 2007