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The Gannon laboratory
uses mouse models to analyze the role of several different transcription
factors in pancreatic development, endocrine cell formation, and
mature islet function. Lab members use genetic strategies for conditional
inactivation or over-expression of these factors (pdx1, HNF6, Foxm1)
in combination with lineage tracing techniques to determine the fate
of the genetically manipulated cells. The main goals of the Gannon
lab are to understand how the different endocrine lineages are established
in the appropriate proportions during embryogenesis, how endocrine
mass is maintained in adulthood, and how endocrine mass is altered
in response to metabolic challenges such as pregnancy, obesity, and
injury.
For
more information about Dr. Gannon visit her Vanderbilt
Faculty Page or her Lab
Website
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