Previous Speakers
2006 Speakers
Sydney Brenner, D.Phil.,
"The Next 100 Years of Biology"
Nancy Andreasen, M.D., Ph.D.,
"The Creative Brain: The Neuroscience of Genius"
Harry Dietz, M.D.,
"Marfan Syndrome and Related Disorders: From Molecules to Medicines"
Marc Tessier-Lavigne, Ph.D.,
"Wiring Nerves, Wiring Vessels: Common Mechanisms of Axon Guidance, Regeneration, and Vascular Patterning"
Marc Kirschner, Ph.D.,
"Protein Degradation and the Timing of Events in the Cell Cycle"
Kathleen Gould, Ph.D.,
"Regulating the end of the cell cycle: splitting up is hard to do"
"The Next 100 Years of Biology"
Nancy Andreasen, M.D., Ph.D.,
"The Creative Brain: The Neuroscience of Genius"
Harry Dietz, M.D.,
"Marfan Syndrome and Related Disorders: From Molecules to Medicines"
Marc Tessier-Lavigne, Ph.D.,
"Wiring Nerves, Wiring Vessels: Common Mechanisms of Axon Guidance, Regeneration, and Vascular Patterning"
Marc Kirschner, Ph.D.,
"Protein Degradation and the Timing of Events in the Cell Cycle"
Kathleen Gould, Ph.D.,
"Regulating the end of the cell cycle: splitting up is hard to do"
2007 Speakers
Jeffrey Conn, Ph.D.,
"Opportunities and Challenges for Drug Discovery in a Postgenomic World"
Antonis K. Hatzopoulos, Ph.D.,
"Stem Cells and Cardiac Regeneration"
Elaine Fuchs, Ph.D.,
"Stem Cells and Their Lineages in Skin"
Tony Hunter, Ph.D.,
"Signal Transduction in Disease and the Response to DNA Damage"
Agnes Fogo, M.D.,
"Chronic Kidney Disease: Can We Stop the Epidemic?"
Emil Unanue, M.D.,
"Cellular and Biochemical Basis for Recognition of Beta Cell Antigens in Autoimmune Diabetes"
Harold (Hal) Moses, M.D.,
"TGF-beta Regulation of Stromal-Epithelial Interactions in Cancer"
Robert Coffey, M.D.,
"The Naked Truth about TGF-α: Lessons Learned from Polarized Epithelial Cells and their Relevance to GI Neoplasia"
Richard Lifton, M.D., Ph.D.,
"Genetics, Genomics and the Future of Medicine"
Kathryn M. Edwards, M.D.,
"From Jenner to Genome: New Approaches to Vaccinology"
Frank E Harrell Jr, Ph.D.,
"Information Allergy"
Bengt Samuelsson, M.D.,
"From Biochemical Mechanisms to Novel Drug Targets: The 5-Lipoxygenase Pathway"
Bradley Efron, Ph.D.,
"Baseball, Shakespeare, and Modern Statistical Theory"
Sir Paul Nurse, Ph.D.,
"Controlling the Cell Cycle"
Sten Vermund, M.D.,
"Vanderbilt Global Health Research into 2008"
Brian Kobilka, M.D.,
"Structure and Dynamics of the Human beta 2 Adrenoceptor"
Richard Hanson, Ph.D.,
"Phosphoenolpyruvate Carboxykinase: The Joy Of Thinking Outside The Box"
"Opportunities and Challenges for Drug Discovery in a Postgenomic World"
Antonis K. Hatzopoulos, Ph.D.,
"Stem Cells and Cardiac Regeneration"
Elaine Fuchs, Ph.D.,
"Stem Cells and Their Lineages in Skin"
Tony Hunter, Ph.D.,
"Signal Transduction in Disease and the Response to DNA Damage"
Agnes Fogo, M.D.,
"Chronic Kidney Disease: Can We Stop the Epidemic?"
Emil Unanue, M.D.,
"Cellular and Biochemical Basis for Recognition of Beta Cell Antigens in Autoimmune Diabetes"
Harold (Hal) Moses, M.D.,
"TGF-beta Regulation of Stromal-Epithelial Interactions in Cancer"
Robert Coffey, M.D.,
"The Naked Truth about TGF-α: Lessons Learned from Polarized Epithelial Cells and their Relevance to GI Neoplasia"
Richard Lifton, M.D., Ph.D.,
"Genetics, Genomics and the Future of Medicine"
Kathryn M. Edwards, M.D.,
"From Jenner to Genome: New Approaches to Vaccinology"
Frank E Harrell Jr, Ph.D.,
"Information Allergy"
Bengt Samuelsson, M.D.,
"From Biochemical Mechanisms to Novel Drug Targets: The 5-Lipoxygenase Pathway"
Bradley Efron, Ph.D.,
"Baseball, Shakespeare, and Modern Statistical Theory"
Sir Paul Nurse, Ph.D.,
"Controlling the Cell Cycle"
Sten Vermund, M.D.,
"Vanderbilt Global Health Research into 2008"
Brian Kobilka, M.D.,
"Structure and Dynamics of the Human beta 2 Adrenoceptor"
Richard Hanson, Ph.D.,
"Phosphoenolpyruvate Carboxykinase: The Joy Of Thinking Outside The Box"
2008 Speakers
Elizabeth Blackburn, Ph.D.,
"Telomeres and Telomerase in Health and Disease"
Ferid Murad, M.D., Ph.D.,
"Discovery of NO and cGMP Signaling and Role in Drug Discovery and Development, Grant R. Wilkinson Distinguished Lectureship in Clinical Pharmacology"
Christine E. Seidman, M.D.,
"Mutations to Mechanisms in Cardiovascular Disease"
Allan Brandt, PhD,
"The Tobacco Pandemic: Ethics, Health, and History"
Solomon Snyder, M.D.,
"Novel Molecular Signaling in Life and Death of Neurons"
Cato T. Laurencin, M.D., Ph.D.,
"Musculoskeletal Regeneration: The Regenerative Engineering Approach"
Kurt Wuthrich, Ph.D.,
"The NMR view of Proteins"
Ron Evans, Ph.D.,
"Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology"
David W. Russell, Ph.D.,
"Cholesterol and Learning: Expect the Unexpected"
Douglas A. Melton, Ph.D.,
"Making pancreatic β cells for diabetics"
Neil R. Powe, M.D., M.P.H., M.B.A.,
"Health and Health Care Disparities: Causes, Consequences and the Will to Conquer "
Ann Graybiel, Ph.D.,
"Our Habitual Lives: How the Brain Makes and Breaks Habits"
Thomas Jessell, Ph.D.,
"Assembly and Organization of Spinal Motor Circuits"
Barbara A. Schaal, Ph.D.,
"Enhancing Nutrition in the Developing World: The Tropical Crop Cassava"
"Telomeres and Telomerase in Health and Disease"
Ferid Murad, M.D., Ph.D.,
"Discovery of NO and cGMP Signaling and Role in Drug Discovery and Development, Grant R. Wilkinson Distinguished Lectureship in Clinical Pharmacology"
Christine E. Seidman, M.D.,
"Mutations to Mechanisms in Cardiovascular Disease"
Allan Brandt, PhD,
"The Tobacco Pandemic: Ethics, Health, and History"
Solomon Snyder, M.D.,
"Novel Molecular Signaling in Life and Death of Neurons"
Cato T. Laurencin, M.D., Ph.D.,
"Musculoskeletal Regeneration: The Regenerative Engineering Approach"
Kurt Wuthrich, Ph.D.,
"The NMR view of Proteins"
Ron Evans, Ph.D.,
"Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology"
David W. Russell, Ph.D.,
"Cholesterol and Learning: Expect the Unexpected"
Douglas A. Melton, Ph.D.,
"Making pancreatic β cells for diabetics"
Neil R. Powe, M.D., M.P.H., M.B.A.,
"Health and Health Care Disparities: Causes, Consequences and the Will to Conquer "
Ann Graybiel, Ph.D.,
"Our Habitual Lives: How the Brain Makes and Breaks Habits"
Thomas Jessell, Ph.D.,
"Assembly and Organization of Spinal Motor Circuits"
Barbara A. Schaal, Ph.D.,
"Enhancing Nutrition in the Developing World: The Tropical Crop Cassava"
2009 Speakers
Eric Nestler, M.D., Ph.D.,
"Transcriptional Mechanisms of Drug Addiction"
Alastair J.J. Wood, MB, ChB,
"Drug Regulation: Time for a radical change"
Shiriki Kumanyika, PhD, MPH ,
"Research to Eliminate Ethnic Disparities in Obesity: Strategic Directions "
Kevin P. Campbell, Ph.D.,
"Muscle Cell Membrane Integrity and the Pathogenesis of Muscular Dystrophy "
Aaron Ciechanover, M.D., D.Sc.,
"The Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and onto Drug Targeting "
Tachi Yamada, M.D.,
"Perspectives on Global Health"
Gerald I. Shulman, M.D., Ph.D.,
"Cellular mechanisms of insulin resistance: Implications for obesity, lipodystrophy and type 2 diabetes "
Charles Rice, Ph.D.,
"Hepatitis C Virus: Twenty Years Later"
Pierre Chambon, M.D.,
"Nuclear Receptors: From Mice to Diseases"
Helen Hobbs, M.D.,
"Genetic Protection from Disorders of Dietary Excess"
Elizabeth G. Nabel, M.D.,
"Genomic Medicine: Cardiovascular Insights from a Premature Aging Syndrome "
Xiaodong Wang, Ph.D. ,
"Understanding Cell Death"
Patricia K. Donahoe, M.D.,
"Pinpointing the Genetic Causes of Birth Defects"
Joan Steitz,
"Regulating the Activity of MicroRNAs in Vertebrate Cells"
Tyler Jacks,
"Lung Cancer Progression"
Richard Lerner,
"Ernest W. Goodpasture Lecture, The Chemistry of Disease"
"Transcriptional Mechanisms of Drug Addiction"
Alastair J.J. Wood, MB, ChB,
"Drug Regulation: Time for a radical change"
Shiriki Kumanyika, PhD, MPH ,
"Research to Eliminate Ethnic Disparities in Obesity: Strategic Directions "
Kevin P. Campbell, Ph.D.,
"Muscle Cell Membrane Integrity and the Pathogenesis of Muscular Dystrophy "
Aaron Ciechanover, M.D., D.Sc.,
"The Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and onto Drug Targeting "
Tachi Yamada, M.D.,
"Perspectives on Global Health"
Gerald I. Shulman, M.D., Ph.D.,
"Cellular mechanisms of insulin resistance: Implications for obesity, lipodystrophy and type 2 diabetes "
Charles Rice, Ph.D.,
"Hepatitis C Virus: Twenty Years Later"
Pierre Chambon, M.D.,
"Nuclear Receptors: From Mice to Diseases"
Helen Hobbs, M.D.,
"Genetic Protection from Disorders of Dietary Excess"
Elizabeth G. Nabel, M.D.,
"Genomic Medicine: Cardiovascular Insights from a Premature Aging Syndrome "
Xiaodong Wang, Ph.D. ,
"Understanding Cell Death"
Patricia K. Donahoe, M.D.,
"Pinpointing the Genetic Causes of Birth Defects"
Joan Steitz,
"Regulating the Activity of MicroRNAs in Vertebrate Cells"
Tyler Jacks,
"Lung Cancer Progression"
Richard Lerner,
"Ernest W. Goodpasture Lecture, The Chemistry of Disease"
2010 Speakers
Melanie H. Cobb, Ph.D.,
"MAPquest – From Cancer to Diabetes"
Gregory S. Barsh, M.D., Ph.D.,
"Genetics of color variation: model systems and model organisms in a post-genome world "
Susan Taylor, Ph.D.,
"Dynamics of Signaling by PKA"
Jean Pierre Changeux, Ph.D.,
"The Nicotinic Receptor: an allosteric membrane protein engaged in neuronal communication - The Logic of Allosteric Receptors in Signal Transduction and Chemical Therapeutics"
Thomas R. Cech, Ph.D.
Nobel Laureate in Chemistry 1989,
"Crawling Out of the RNA World"
Kathy Giacomini,
"Personalizing Anti-diabetic Drug Therapy"
Discovery Lecture/Lamb Center 20th Anniversary Symposium
Peter Schultz,
"A Chemist's Foray into Translational Research: From Stem Cells to Orphan Diseases"
Svante Pääbo,
"A Neandertal Perspective on Human Origins"
Jacek J. Hawiger, M.D., Ph.D.,
"The Joy of Crossing Borders"
Vern L. Schramm, Ph.D.,
"Enzymatic Transition States and Drug Design"
Martin Chalfie, Ph.D.,
"Touch Sensitivity in C. elegans: An Adventure in Nontranslational Research"
Max Essex, DVM/MS, Ph.D.,
"HIV-1C of Southern Africa: Treatment for Prevention"
Jean-Laurent Casanova, M.D., Ph.D.,
"Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?"
Susan Lindquist, Ph.D.,
"Protein Homeostasis: Regulating a Crucial Balance in Heath and Disease."
"MAPquest – From Cancer to Diabetes"
Gregory S. Barsh, M.D., Ph.D.,
"Genetics of color variation: model systems and model organisms in a post-genome world "
Susan Taylor, Ph.D.,
"Dynamics of Signaling by PKA"
Jean Pierre Changeux, Ph.D.,
"The Nicotinic Receptor: an allosteric membrane protein engaged in neuronal communication - The Logic of Allosteric Receptors in Signal Transduction and Chemical Therapeutics"
Thomas R. Cech, Ph.D.
Nobel Laureate in Chemistry 1989,
"Crawling Out of the RNA World"
Kathy Giacomini,
"Personalizing Anti-diabetic Drug Therapy"
Discovery Lecture/Lamb Center 20th Anniversary Symposium
Peter Schultz,
"A Chemist's Foray into Translational Research: From Stem Cells to Orphan Diseases"
Svante Pääbo,
"A Neandertal Perspective on Human Origins"
Jacek J. Hawiger, M.D., Ph.D.,
"The Joy of Crossing Borders"
Vern L. Schramm, Ph.D.,
"Enzymatic Transition States and Drug Design"
Martin Chalfie, Ph.D.,
"Touch Sensitivity in C. elegans: An Adventure in Nontranslational Research"
Max Essex, DVM/MS, Ph.D.,
"HIV-1C of Southern Africa: Treatment for Prevention"
Jean-Laurent Casanova, M.D., Ph.D.,
"Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?"
Susan Lindquist, Ph.D.,
"Protein Homeostasis: Regulating a Crucial Balance in Heath and Disease."
2011 Speakers
Leonard Zon, M.D.,
"Pathways Regulating Self-Renewal in Blood Stem Cells"
Meir Stampfer, M.D., Dr.P.H.,
"Eating, Drinking, and Staying Healthy: Primary Prevention of Chronic Diseases through Diet and Lifestyle"
E. Albert Reece, M.D., Ph.D., M.B.A., F.A.C.O.G.,
"Unraveling the Syndrome of Diabetic Embryopathy"
Roger D. Cone, Ph.D.,
"Energy in, energy out: What syndromic obesity has taught us about how the brain regulates body weight"
Huda Zoghbi, M.D.,
"Rett Syndrome and MECP2 Disorders: Linking Epigenetics to Neurobiology"
Vanderbilt Prize in Biomedical Science Lecture
Nancy Andrews, M.D., Ph.D.,
"Forging an Understanding of Iron Homeostasis"
Randy Schekman, Ph.D. ,
"Protein Sorting in the Secretory Pathway: Basic Principles and Consequences for Human Disease "
Alfred Sommer, M.D. M.H.S.,
"What I Discovered While Discovering: A Peripatetic Adventure"
Shirley Tilghman, Ph.D.,
"The Meaning of Race in the Post-Genome Era"
Russ Doolittle, Ph.D.,
"Searching for the Roots of Blood Clotting: A Bioinformatics Approach "
Michael R. DeBaun, M.D., MPH,
"Discovery at the Bedside: The Intersection Between Asthma and Sickle Cell Disease"
Eric Topol, M.D.,
"How Digitizing Human Beings Changed the Future of Medicine"
Lora Hooper, Ph.D.,
"Immune Adaptations to the Intestinal Microbiota"
Gina Kolata, M.S.,
"Discovering Science Stories: What makes them news?"
Bruce Spiegelman, Ph.D.,
"Transcriptional Control of Adipogenesis: Toward a New Generation of Therapeutics"
Kevin Johnson, M.D.,
"Evaluating Electronic Health Information Exchange: An Exemplar of the Science in Clinical Informatics"
Andy Feinberg, M.D., MPH,
"The Epigenetic Basis of Common Human Disease"
"Pathways Regulating Self-Renewal in Blood Stem Cells"
Meir Stampfer, M.D., Dr.P.H.,
"Eating, Drinking, and Staying Healthy: Primary Prevention of Chronic Diseases through Diet and Lifestyle"
E. Albert Reece, M.D., Ph.D., M.B.A., F.A.C.O.G.,
"Unraveling the Syndrome of Diabetic Embryopathy"
Roger D. Cone, Ph.D.,
"Energy in, energy out: What syndromic obesity has taught us about how the brain regulates body weight"
Huda Zoghbi, M.D.,
"Rett Syndrome and MECP2 Disorders: Linking Epigenetics to Neurobiology"
Vanderbilt Prize in Biomedical Science Lecture
Nancy Andrews, M.D., Ph.D.,
"Forging an Understanding of Iron Homeostasis"
Randy Schekman, Ph.D. ,
"Protein Sorting in the Secretory Pathway: Basic Principles and Consequences for Human Disease "
Alfred Sommer, M.D. M.H.S.,
"What I Discovered While Discovering: A Peripatetic Adventure"
Shirley Tilghman, Ph.D.,
"The Meaning of Race in the Post-Genome Era"
Russ Doolittle, Ph.D.,
"Searching for the Roots of Blood Clotting: A Bioinformatics Approach "
Michael R. DeBaun, M.D., MPH,
"Discovery at the Bedside: The Intersection Between Asthma and Sickle Cell Disease"
Eric Topol, M.D.,
"How Digitizing Human Beings Changed the Future of Medicine"
Lora Hooper, Ph.D.,
"Immune Adaptations to the Intestinal Microbiota"
Gina Kolata, M.S.,
"Discovering Science Stories: What makes them news?"
Bruce Spiegelman, Ph.D.,
"Transcriptional Control of Adipogenesis: Toward a New Generation of Therapeutics"
Kevin Johnson, M.D.,
"Evaluating Electronic Health Information Exchange: An Exemplar of the Science in Clinical Informatics"
Andy Feinberg, M.D., MPH,
"The Epigenetic Basis of Common Human Disease"
2012 Speakers
Risa Lavizzo-Mourey, M.D., M.B.A.,
"Reversing Childhood Obesity: Helping All Children Lead Healthier Lives"
Vanderbilt Prize Winner - Titia de Lange, Ph.D. ,
"How telomeres solve the end-protection problem"
Trudi Schupbach, Ph.D.,
"Control of EGF Receptor Activity and Axis Establishment in Drosophila Oogenesis"
Eric Wieschaus, Ph.D.,
"Mechanics of Cell Shape Change in Drosophila"
Gail Martin, Ph.D.,
"FGF signaling in vertebrate organogenesis: how Sprouty genes help to get it right"
Jim Wells, Ph.D.,
"Engineering Cells to Death"
Jeff Wrana, Ph.D.,
"Intersection of Polarity and Morphogen Pathways in Development and Cancer"
R. Alta Charo, J.D.,
"Faster, Safer, Better: Thoughts on Pharmaceutical Development"
Kerry J. Ressler, M.D., Ph.D.,
"Fear from Mice to Men: Implications for PTSD and other Disorders of Fear and Anxiety"
Joe Palca, Ph.D.,
"News and Science: A Marriage of Convenience"
Phillip A. Sharp, Ph.D.,
"The biology of non-coding RNAs"
Mriganka Sur, Ph.D.,
"Mechanisms and Emerging Therapeutics for Autism Spectrum Disorders"
Lynne E. Maquat, Ph.D.,
"Tales from the Cellular Underworld: mRNA Decay and Disease"
Thomas C. Südhof, M.D.,
"Physiology and Pathology of Neurotransmitter Release"
"Reversing Childhood Obesity: Helping All Children Lead Healthier Lives"
Vanderbilt Prize Winner - Titia de Lange, Ph.D. ,
"How telomeres solve the end-protection problem"
Trudi Schupbach, Ph.D.,
"Control of EGF Receptor Activity and Axis Establishment in Drosophila Oogenesis"
Eric Wieschaus, Ph.D.,
"Mechanics of Cell Shape Change in Drosophila"
Gail Martin, Ph.D.,
"FGF signaling in vertebrate organogenesis: how Sprouty genes help to get it right"
Jim Wells, Ph.D.,
"Engineering Cells to Death"
Jeff Wrana, Ph.D.,
"Intersection of Polarity and Morphogen Pathways in Development and Cancer"
R. Alta Charo, J.D.,
"Faster, Safer, Better: Thoughts on Pharmaceutical Development"
Kerry J. Ressler, M.D., Ph.D.,
"Fear from Mice to Men: Implications for PTSD and other Disorders of Fear and Anxiety"
Joe Palca, Ph.D.,
"News and Science: A Marriage of Convenience"
Phillip A. Sharp, Ph.D.,
"The biology of non-coding RNAs"
Mriganka Sur, Ph.D.,
"Mechanisms and Emerging Therapeutics for Autism Spectrum Disorders"
Lynne E. Maquat, Ph.D.,
"Tales from the Cellular Underworld: mRNA Decay and Disease"
Thomas C. Südhof, M.D.,
"Physiology and Pathology of Neurotransmitter Release"
2013 Speakers
Brenda A. Schulman, Ph.D.,
"Twists and Turns in Ubiquitin Conjugation Cascade"
Andrew Z. Fire, Ph.D.,
"Biological responses to foreign information"
C. Ronald Kahn, M.D.,
"Insulin, Diabetes, and the Control of Brain Metabolism"
Scott Hultgren, Ph.D.,
"Molecular Blueprint of Uropathogenic E. coli Pathogenesis and Targeted Therapies"
Jonathan G. Seidman, Ph.D.,
"Next generation sequencing has revolutionized cardiovascular genetics"
Jeffrey A. Whitsett, M.D.,
"Transcriptional networks regulating lung formation and alveolar homeostasis: Lessons from newborn infants"
Professor Sir Rory Collins,
"Size matters: The Need for Large-scale Population Studies"
"Twists and Turns in Ubiquitin Conjugation Cascade"
Andrew Z. Fire, Ph.D.,
"Biological responses to foreign information"
C. Ronald Kahn, M.D.,
"Insulin, Diabetes, and the Control of Brain Metabolism"
Scott Hultgren, Ph.D.,
"Molecular Blueprint of Uropathogenic E. coli Pathogenesis and Targeted Therapies"
Jonathan G. Seidman, Ph.D.,
"Next generation sequencing has revolutionized cardiovascular genetics"
Jeffrey A. Whitsett, M.D.,
"Transcriptional networks regulating lung formation and alveolar homeostasis: Lessons from newborn infants"
Professor Sir Rory Collins,
"Size matters: The Need for Large-scale Population Studies"
 |
Marc Kirschner, Ph.D.
Chair of Systems Biology, Harvard Medical School; National Academy of Sciences member (Orrin Ingram Distinguished Lecturer, Vanderbilt-Ingram Cancer Center; Cell and Developmental Biology Distinguished Faculty Lecturer) |
Protein Degradation and the Timing of Events in the Cell Cycle
November 6, 2006
Click below to view the entire archived webcast of this lecture.
Windows Media Player | RealPlayer
Click below to view the entire archived webcast of this lecture.
Windows Media Player | RealPlayer