Knowledge Management

Issue Highlights

Issue Highlights

Issue Highlights

Issue Highlights

Issue Highlights

1.  Clinical questions recently sent to the EBM Literature Request message basket in StarPanel
   • Evidence suggests mental exercises may maintain cognitive thinking skills for specific tasks by elderly patients
   • Evidence for adding low-dose aspirin to warfarin therapy in artificial heart valve patients
   • Consenting patients with cognitive impairment for surgical procedures
2.  Clinical Practice Guidelines
   • USPSTF recommends against routine screening for colorectal cancer in patients older than 75 years
   • CDC releases new and expanded Hepatitis B testing recommendations
   • ACP recommends considering drug therapy for patients at risk for osteoporosis
3.  Newly Published Research
   • Multicenter RCT shows no significant difference in time to death with rosuvastatin vs placebo in CHF patients
   • RCT shows conflicting results for daily high-dose vitamin KI on bone loss and fractures in postmenopausal women with osteopenia
   • Randomized trial shows no difference between episodic and continuous amiodarone therapy for major adverse events in ambulatory patients with recurrent persistent a-fib
   • Multicenter RCT shows no significant change in cognition with vitamin B regimen versus placebo in AD patients
4.  FDA News & Safety Advisories
   • FDA receives additional data from manufacturer of Spiriva HandiHaler showing no increased risk of stroke
   • FDA postmarketing adverse event review finds no significant incidence or risk of ALS with statin use
   • FDA continues ongoing safety review of risk of atrial fibrillation in patients taking bisphosphonates

Issue Highlights

1.  Clinical questions recently sent to the EBM Literature Request message basket in StarPanel
   • Limited evidence for management of recurrent infection with chronic indwelling urinary catheters
   • Conflicting evidence for efficacy and duration of benefit with Synvisc for elderly patients with osteoarthritis
   • Adding low-dose aspirin to anticoagulation therapy may aid patients with artificial heart valves
   • Literature lacks strong evidence for management of UTI in adults with chronic urinary calculi
2.  Clinical Practice Guidelines
   • USPSTF concludes available evidence is insufficient regarding prostate cancer screening
   • USPSTF recommends screening asymptomatic adults for type 2 diabetes based on blood pressure level
   • ACIP Finalizes Zoster Vaccine Recommendations
3.  Newly Published Research
   • Dimebon shows significant improvement in cognition for patients with mild-to-moderate Alzheimer’s
   • Randomized trial of fish oil supplementation does not show significant cognitive improvement in older adults
   • Problem-solving therapy as collaborative care within a primary care clinic compared to usual care effective for reducing late-life depression in older adults
   • Tibolone reduces fracture risk and breast cancer risk but increases stroke risk in older women with osteoporosis
4.  FDA News & Safety Advisories
   • FDA warns of increased mortality risk in elderly patients treated with antipsychotics for dementia-related psychosis
   • CDC releases framework monograph for translating public health research on caregiving into practice
   • Medicare Improvements for Patients and Providers Act of 2008 Enacted