Blakely Lab

The Blakely Lab

Randy Blakely, Ph.D.


Randy Headshot

Allan D. Bass Professor of Pharmacology and Psychiatry

Director, Silvio O. Conte Center for Neuroscience Research

Director, Vanderbilt Postdoctoral Training Program in Neurogenomics

Email: randy.blakely@vanderbilt.edu


THE BLAKELY LAB
at Florida Atlantic University

Stacks Image 24224




Stacks Image 0
Stacks Image 2604
Stacks Image 2606
Stacks Image 2608
Stacks Image 2610
Stacks Image 2612
Stacks Image 2614
Stacks Image 2616
Stacks Image 2618
Stacks Image 2620
Stacks Image 2624
Stacks Image 2626
Stacks Image 2628
Stacks Image 2630
Stacks Image 2632
Stacks Image 2634
Stacks Image 2636


Randy D. Blakely, Ph. D.
Executive Director, FAU Brain Institute
Director, Silvio O. Conte Center for Neuroscience Research






Stacks Image 10153


My laboratory explores mechanisms of synaptic regulation, focusing on how clearance of neurotransmitters by presynaptic and glial transporters regulates neurotransmitter signaling capacity. We use molecular biology, transcriptomic and proteomic methods, model system genetics (C. elegans, recombinant inbred mice), molecular and cellular imaging approaches, electrophysiological paradigms, and transgenic mouse approaches to identify mechanisms by which neurotransmitter transporters insure normal synaptic function and how disease risk is impacted by transporter dysfunction. We also seek to understand how drugs, including antidepressants (e.g. SSRIs) and psychostimulants (e.g. cocaine, ADHD medications) carry out their actions. Finally, we seek to understand the web of molecular interactions that act in concert with, or regulate neurotransmitter transporters to insure proper synaptic signaling and plasticity.




Stacks Image 25675
Congratulations to Daniel Bermingham, who successfully defended his PhD thesis, The Conserved MAP Kinase SWIP-13/ERK8 Regulates Dopamine Signaling Through Control of the Presynaptic Dopamine Transporter, on April 26, 2016.



Stacks Image 25637
Congratulations to Alex Nackenoff on successfully defending his PhD thesis, Determination of Requisite SERT Antagonism for the Acute and Chronic Behavioral and Biochemical Antidepressant Effects of SSRIs, as Revealed Utilizing the SERT Met 172 Mouse Model, on March 14th, 2016.



Stacks Image 25653
Congratulations to Elizabeth Ennis on successfully defending her PhD thesis, Identification and Characterization of Novel Inhibitors of the Presynaptic, Hemicholinium-3-Sensitive Choline Transporter on February 12, 2016.



Stacks Image 2544
Congratulations to Meagan Quinlan for receipt of a travel award to present her work at the 2016 Meeting of the International Society for Serotonin Research.



Stacks Image 2525
Established in 2007, the Next Generation award recognizes Society for Neuroscience's chapter members who have made outstanding contributions to public communication, outreach and education about neuroscience. Congratulations to Nicole Baganz for winning this year's award for her efforts with the local chapter of NAMI, outreach efforts with yoga, neuroscience and Eastern medicine, and organizing Vanderbilt's Music and Mind Exposition.



Stacks Image 5454
Congrats to Neuroscience Ph.D. Student Gwynne Davis for awarding of a Fellowship from the National Institute of Mental Health to pursue “In Vivo Modeling of Heritable Dopamine Transporter Dysfunction Associated with Neuropsychiatric Disorders”



Stacks Image 2455
Congratulations to Dr. Matthew Robson for receiving a two-year NARSAD Young Investigator Award from the Brain and Behavioral Research Foundation.


Stacks Image 15