THE BLAKELY LAB
Randy D. Blakely, Ph. D.
Allan D. Bass Professor of Pharmacology and Psychiatry
Director, Silvio O. Conte Center for
Vanderbilt Postdoctoral Training Program
in Functional Neurogenomics
My laboratory explores mechanisms of synaptic regulation, focusing on how clearance of neurotransmitters by presynaptic and glial transporters regulates neurotransmitter signaling capacity. We use molecular biology, transcriptomic and proteomic methods, model system genetics (C. elegans, recombinant inbred mice), molecular and cellular imaging approaches, electrophysiological paradigms, and transgenic mouse approaches to identify mechanisms by which neurotransmitter transporters insure normal synaptic function and how disease risk is impacted by transporter dysfunction. We also seek to understand how drugs, including antidepressants (e.g. SSRIs) and psychostimulants (e.g. cocaine, ADHD medications) carry out their actions. Finally, we seek to understand the web of molecular interactions that act in concert with, or regulate neurotransmitter transporters to insure proper synaptic signaling and plasticity.
To learn more about Dr. Freeman, her research on the dopamine transporter in C. elegans and her role at Fisk University, please click here.