Blakely Lab

The Blakely Lab

Randy Blakely, Ph.D.


Randy Headshot

Allan D. Bass Professor of Pharmacology and Psychiatry

Director, Silvio O. Conte Center for Neuroscience Research

Director, Vanderbilt Postdoctoral Training Program in Neurogenomics

Email: randy.blakely@vanderbilt.edu


THE BLAKELY LAB


Stacks Image 0
Stacks Image 1
Stacks Image 2
Stacks Image 3
Stacks Image 4
Stacks Image 5
Stacks Image 6
Stacks Image 7
Stacks Image 8
Stacks Image 9
Stacks Image 10
Stacks Image 11
Stacks Image 12
Stacks Image 487
Stacks Image 488
Stacks Image 489
Stacks Image 490


Randy D. Blakely, Ph. D.
Allan D. Bass Professor of Pharmacology and Psychiatry
Director, Silvio O. Conte Center for
Neuroscience Research
Vanderbilt Postdoctoral Training Program
in Functional Neurogenomics


Stacks Image 461





My laboratory explores mechanisms of synaptic regulation, focusing on how clearance of neurotransmitters by presynaptic and glial transporters regulates neurotransmitter signaling capacity. We use molecular biology, transcriptomic and proteomic methods, model system genetics (C. elegans, recombinant inbred mice), molecular and cellular imaging approaches, electrophysiological paradigms, and transgenic mouse approaches to identify mechanisms by which neurotransmitter transporters insure normal synaptic function and how disease risk is impacted by transporter dysfunction. We also seek to understand how drugs, including antidepressants (e.g. SSRIs) and psychostimulants (e.g. cocaine, ADHD medications) carry out their actions. Finally, we seek to understand the web of molecular interactions that act in concert with, or regulate neurotransmitter transporters to insure proper synaptic signaling and plasticity.



Stacks Image 13
Stacks Image 14
Stacks Image 15