THE BLAKELY LAB
Randy Blakely, Ph. D.
Allan D. Bass Professor of Pharmacology and Psychiatry
Director, Silvio O. Conte Center for
Vanderbilt Postdoctoral Training Program
Click here for Dr. Blakely's Curriculum Vitae
updated 3 May 2013
My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation.
We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters.
We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods.
We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.