Blakely Lab

The Blakely Lab

The Blakely Lab: Recent Publications

2016 Publications

Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016 Jun;41(7):1733-41. doi: 10.1038/npp.2015.335. Epub 2015 Oct 30. PMID: 26514584; PubCentral PMCID: PMC4869040.

Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25. PMID: 27111230

Ennis EA, Blakely RD. Choline on the Move: Perspectives on the Molecular Physiology and Pharmacology of the Presynaptic Choline Transporter. Adv Pharmacol. 2016;76:175-213. doi: 10.1016/bs.apha.2016.03.001. Epub 2016 Apr 7. PMID: 27288078

Iwamoto H, Calcutta MW, Blakely RD. Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine. Neurochem Int. 2016 Mar 22. pii: S0197-0186(16)30038-9. doi: 10.1016/j.neuint.2016.03.012. [Epub ahead of print] PMID: 27013347

Robson MJ, Zhu CB, Quinlan MA, Botschner DA, Baganz NL, Lindler KM, Thome JG, Hewlett WA, Blakely RD. Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. PLoS One. 2016 Mar 1;11(3):e0150068. doi: 10.1371/journal.pone.0150068. eCollection 2016. PubMed PMID: 26930558; PubMed Central PMCID: PMC4773179.

Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD. Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. Neurochem Int. 2016 Feb 3. pii: S0197 0186(16)30008-0. doi: 10.1016/j.neuint.2016.01.008. [Epub ahead of print] PubMed PMID: 26850478.

Ye R, Quinlan MA, Iwamoto H, Wu HH, Green NH, Jetter CS, McMahon DG, Veestra-VanderWeele J, Levitt P, Blakely RD. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Front Synaptic Neurosci. 2016 Jan 11;7:20. doi: 10.3389/fnsyn.2015.00020. eCollection 2015. PubMed PMID: 26793096; PubMed Central PMCID: PMC4707279.

2015 Publications

Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H, Deneris ES, Hewlett WA, Blakely RD. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Transl Psychiatry. 2015 Nov 3;5:e671. doi: 10.1038/tp.2015.168. PubMed PMID: 26529424.

Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM 3rd, Carvelli L, Hardie SL, Blakely RD. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. J Neurosci. 2015 Jun 24;35(25):9409-23. doi: 10.1523/JNEUROSCI.0800-15.2015 [PMID: 26109664]

Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Genetic Variation in Alpha2-Adrenoreceptors and Heart Rate Recovery after Exercise. Physiol Genomics. 2015 Jun 9:physiolgenomics.00124.2014.doi:10.1152/physiolgenomics.00124.2014 Epub ahead of print. [PMID: 26058836]

Bollinger SR, Engers DW, Ennis EA, Wright J, Locuson CW, Lindsley CW, Blakely RD, Hopkins CR. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1757-60. doi: 10.1016/j.bmcl.2015.02.058. Epub 2015 Feb 28. [PMID: 25801932; PMCID: PMC4385452]

Kovtun O, Sakrikar D, Tomlinson ID, Chang JC, Arzeta-Ferrer X, Blakely RD, Rosenthal SJ. Single-Quantum-Dot Tracking Reveals Altered Membrane Dynamics of an Attention-Defecit/Hyperactivity-Disorder-Derived Dopamine Transporter Coding Variant. ACS Chem Neurosci. 2015 Mar 16. Epub ahead of print. [PMID: 25747272]

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. 3D visualization of the regional differences. Mol Psychiatry. 2015 Feb; 20(1):1 doi: 10.1038/mp.2014.168 [PMID: 25648202]

Chen X, Ye R, Gargus JJ,
Blakely RD, Dobrenis K, Sze JY. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01062-6. doi: 10.1016/j.celrep.2014.12.033. Epub ahead of print. [PMID: 25600870]

Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR,
Blakely RD. Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27. doi: 10.1021/cn5001809. Epub 2015 Feb 2. [PMID: 25560927; PMCID: PMC4367188]

Berry AS,
Blakely RD, Sarter M, Lustig C. Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics. Neuroimage. 2015 Mar; 108:386-95. doi: 10.1016/j.neuroimage.2014.12.036. Epub 2014 Dec 20. [PMID: 25536497; PubMed in process]

2014 Publications

Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior and alters in vivo responses to psychostimulants. Proc Natl Acad Sci USA, 2014 Nov 4;111(44):E4779-88 [PMID: 25331903; PMCID: PMC4226116]

Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJ, Erreger K, Galli A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014 Oct 14;4:e464. doi: 10.1038/tp2014.90. [PMID: 25313507; PubMed - in process].

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry. 2014 Sep 9. doi 10.1038/mp.2014.98. Epub ahead of print. [PMID: 25199916; PubMed - as supplied by publisher].

Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 2014 Sep 5;275:184-93. doi: 10.1016/j.neuroscience.2014.06.012. Epub 2014 Jun 17. [PMID: 24950119; PMCID: PMC4122660].

Hardaway JA, Wang J, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. J Neurosci Methods. 2014 May 2:232C:58-62. doi: 10.1016/j.neumeth.2014.04.024 Epub ahead of print [PMID: 24792527; PubMed--as supplied by publisher].

Blakely RD, Ortega A, Robinson MB. The brain in flux: genetic, physiologic, and therapeutic perspectives on transporters in the CNS. Neurochem Int. 2014 Jul;73:1-3. doi: 10.1016/j.neuint.2014.04.008. Epub 2014 Apr 18. No abstract available. [PMID: 24751395; PubMed - in process].

Berry AS, Demeter E, Sabhapathy S, English BA, Blakely RD, Sarter M, Lustig C. Disposed to Distraction: Genetic Variation in the Cholinergic System Influences Distractibility But Not Time-on-Task Effects. J Cogn Neurosci. 2014 Mar 25. Epub ahead of print [PMID: 24666128; PubMed – in process].

Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J Neurochem, 2014 Jul;130(1):109-14. doi: 10.1111/jnc.12697, Epub 2014 Mar 18 [PMID 24611756; PMCID: PMC4065617].

Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes Brain Behav. 2014 Mar;13(3):261-75. doi: 10.1111/gbb.12119. Epub 2014 Feb 6 [PMID: 24405699; PubMed – in process].

Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan;466(1):25-42, doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13 [PMID: 24337881, PMCID: PMC3930102].

Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: On the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70. doi 10/1016/j.neuint.2013.11.009. Epub 2013 Dec 8 [PMID: 24332984; PMCID: PMC 4177817].

Holmstrand EC, Lund D., Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochem Int. 2014 Jul;73:217-28. doi: 10.1016/j.neuint.2013.11.008. Epub 2013 Nov 22 [PMID: 24274995; PMCID: PMC4104494].

Gowrishankar R, Hahn MK, Blakely RD. Good riddance to dopamine: Roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. Neurochem Int. 2014 Jul;73:42-8. doi: 10.1016/j.neuint.2013.10.016. Epub 2013 Nov 11 [PMID: 24231471; PubMed – in process].

Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 2014 Mar;13(3):247-60. doi: 10.1111/gbb.12092. Epub 2013 Oct 31 [PMID: 24102824; PMCID: PMC3979832].

2013 Publications

Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem, 2013 Jan 4;288(1):20-32, [PMID: 23161550; PMCID: PMC3537014].

Baganz NL, Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci, 2013 Jan 16;4(1):48-63, [PMID: 23336044; PMCID: PMC3547518].

Parikh V, St. Peters M, Blakely RD, Sarter M. The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci, February 6, 2013, 33(6):2326-2337, [PMID: 23392663; PMCID: PMC3711270].

Paolone G, Mallory CS, Koshy Cherian A, Miller TR, Blakely RD, Sarter M. Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: A model of cholinergic capacity limits. Neuropharmacology, 2013 Aug 16; 75C:274-285, [PMID: 23958450].

Campbell NG, Zhu CB, Lindler KM, Yaspan BL, Kistner-Griffin E; NIH ARRA Consortium, Hewlett WA, Tate CG, Blakely RD, Sutcliffe JS. Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Mol Autism. 2013 Aug 16;4(1)28, [PMID: 23953133].

Kerr TM, Muller CL, Miah M, Jetter CS, Pfeiffer R, Shah C, Baganz N, Anderson GM, Crawley JN, Sutcliffe JS, Blakely RD, Veenstra-Vanderweele J. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice. Mol Autism. 2013 Oct 1; 4(1):35, [PMID: 24083388].

Dong Y, Dani JA, Blakely RD. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochem Pharmacol. 2013 Oct 15; 86(8):1084-8, [PMID: 23939187].

2010 Publications Page

2009 Publications Page