Blakely Lab

The Blakely Lab

The Blakely Lab: Recent Publications

2014 Publications

Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior and alters in vivo responses to psychostimulants. Proc Natl Acad Sci USA, 2014 Nov 4;111(44):E4779-88 [PMID: 25331903; PMCID: PMC4226116]

Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJ, Erreger K, Galli A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014 Oct 14;4:e464. doi: 10.1038/tp2014.90. [PMID: 25313507; PubMed - in process].

Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry. 2014 Sep 9. doi 10.1038/mp.2014.98. Epub ahead of print. [PMID: 25199916; PubMed - as supplied by publisher].

Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 2014 Sep 5;275:184-93. doi: 10.1016/j.neuroscience.2014.06.012. Epub 2014 Jun 17. [PMID: 24950119; PMCID: PMC4122660].

Hardaway JA, Wang J, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. J Neurosci Methods. 2014 May 2:232C:58-62. doi: 10.1016/j.neumeth.2014.04.024 Epub ahead of print [PMID: 24792527; PubMed--as supplied by publisher].

Blakely RD, Ortega A, Robinson MB. The brain in flux: genetic, physiologic, and therapeutic perspectives on transporters in the CNS. Neurochem Int. 2014 Jul;73:1-3. doi: 10.1016/j.neuint.2014.04.008. Epub 2014 Apr 18. No abstract available. [PMID: 24751395; PubMed - in process].

Berry AS, Demeter E, Sabhapathy S, English BA, Blakely RD, Sarter M, Lustig C. Disposed to Distraction: Genetic Variation in the Cholinergic System Influences Distractibility But Not Time-on-Task Effects. J Cogn Neurosci. 2014 Mar 25. Epub ahead of print [PMID: 24666128; PubMed – in process].

Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J Neurochem, 2014 Jul;130(1):109-14. doi: 10.1111/jnc.12697, Epub 2014 Mar 18 [PMID 24611756; PMCID: PMC4065617].

Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes Brain Behav. 2014 Mar;13(3):261-75. doi: 10.1111/gbb.12119. Epub 2014 Feb 6 [PMID: 24405699; PubMed – in process].

Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan;466(1):25-42, doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13 [PMID: 24337881, PMCID: PMC3930102].

Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: On the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70. doi 10/1016/j.neuint.2013.11.009. Epub 2013 Dec 8 [PMID: 24332984; PMCID: PMC 4177817].

Holmstrand EC, Lund D., Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochem Int. 2014 Jul;73:217-28. doi: 10.1016/j.neuint.2013.11.008. Epub 2013 Nov 22 [PMID: 24274995; PMCID: PMC4104494].

Gowrishankar R, Hahn MK, Blakely RD. Good riddance to dopamine: Roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. Neurochem Int. 2014 Jul;73:42-8. doi: 10.1016/j.neuint.2013.10.016. Epub 2013 Nov 11 [PMID: 24231471; PubMed – in process].

Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 2014 Mar;13(3):247-60. doi: 10.1111/gbb.12092. Epub 2013 Oct 31 [PMID: 24102824; PMCID: PMC3979832].

2013 Publications

Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem, 2013 Jan 4;288(1):20-32, [PMID: 23161550; PMCID: PMC3537014].

Baganz NL, Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci, 2013 Jan 16;4(1):48-63, [PMID: 23336044; PMCID: PMC3547518].

Parikh V, St. Peters M, Blakely RD, Sarter M. The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci, February 6, 2013, 33(6):2326-2337, [PMID: 23392663; PMCID: PMC3711270].

Paolone G, Mallory CS, Koshy Cherian A, Miller TR, Blakely RD, Sarter M. Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: A model of cholinergic capacity limits. Neuropharmacology, 2013 Aug 16; 75C:274-285, [PMID: 23958450].

Campbell NG, Zhu CB, Lindler KM, Yaspan BL, Kistner-Griffin E; NIH ARRA Consortium, Hewlett WA, Tate CG, Blakely RD, Sutcliffe JS. Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Mol Autism. 2013 Aug 16;4(1)28, [PMID: 23953133].

Kerr TM, Muller CL, Miah M, Jetter CS, Pfeiffer R, Shah C, Baganz N, Anderson GM, Crawley JN, Sutcliffe JS, Blakely RD, Veenstra-Vanderweele J. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice. Mol Autism. 2013 Oct 1; 4(1):35, [PMID: 24083388].

Dong Y, Dani JA, Blakely RD. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochem Pharmacol. 2013 Oct 15; 86(8):1084-8, [PMID: 23939187].

2010 Publications Page

2009 Publications Page