CHARLES TESSIER:
Project Summary:
I am interested in understanding the molecular basis of Fragile X Syndrome. Fragile X is caused by the loss of the translational regulator FMRP. FMRP binds to specific mRNAs and via an unknown mechanism represses their translation. I am particularly focused on determining the role that neuronal activation plays in FMRP function. FMRP is upregulated in response to stimulation and likewise repressed during forced repression of neuronal firing. I am using a battery of genetic, molecular, and imaging tools to investigate activity-dependent processes of brain maturation and the effect of these processes on FMRP target mRNAs and interacting proteins
Education:
| 2005-current: | Postdoctoral research associate. Laboratory of Kendal Broadie. Vanderbilt University-Nashville, TN |
| 1999-2005: | Ph.D.-Cell and Molecular Biology. Laboratory of Dr. Jeff Ross. University of Wisconsin–Madison, Madison, WI. |
| 1995-1999: | BA-Biochemistry. BA-Biology. Clark University, Worcester, MA. |
Publications:
Tessier, C.R., G.A. Doyle, B.A. Clark, H.C. Pitot, and J. Ross. Mammary Tumor Induction in Transgenic Mice Expressing an RNA-Binding Protein. Cancer Res., 64: 209-214, 2004.