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molecular-level imaging of
whole cells

Innovative Electron Microscopy
This research program aims at developing new scanning transmission electron microscopy (STEM) techniques for biomedical research to investigate the molecular machinery underlying cellular function. Electron microscopy presently has its strength in imaging with high spatial resolution. New phenomena may be discovered by improving the capabilities of time-resolved and three-dimensional (3D) imaging under native conditions. The program includes research on imaging of biological specimen with Liquid STEM, 3D STEM, in situ STEM, and aberration corrected STEM. This research is conducted by an interdisciplinary team of biophysicists, cellbiologists, chemists, computer scientists, and materials scientists. The research group was situated in the department of Molecular Physiology and Biophysics of the at Vanderbilt University School of Medicine (VUMC) until Dec. 2011. Dr. Niels de Jonge leads the group Innovative Electron Microscopy at the INM Leibniz-Institute for New Materials, in Saarbrücken, Germany, since Jan. 2012. Various collaborations exist with research groups at VUMC.


2nd Conference on In-Situ and Correlative Electron Microscopy
October 14-15, 2014, Saarbrücken, Germany

Special issue on electron microscopy of specimens in liquids in Microscopy and Microanalysis. link

EGFR subunit locations determined in hydrated cells with ESEM, Scientific Reports 3, 2626, 2013.






High resolution electron microscopy

Diana Peckys and Niels de Jonge at the JEOL ARM200F of the INM-Leibniz Institute for New Materials, Saarbrücken, Germany

Foto ©Uwe Bellhäuser



Copyright © 2009 by Vanderbilt University Medical Center
Last updated February 1, 2015