||Sergey Dikalov, PHD
Associate Professor of Medicine
Director of FFRIMCORE
Division of Clinical Pharmacology
Vanderbilt University Medical Center
Welcome to our website! Our lab studies the diverse pathophysiological role of reactive oxygen species (ROS) such as superoxide radical (O2•), hydrogen peroxide (H2O2), nitric oxide (NO·) and peroxynitrite (ONOO−). We were one of the first groups reported on development of mitochondrial oxidative stress and mitochondrial impairment under conditions of endothelial dysfunction and hypertension. Our lab has uncovered specific molecular mechanisms of mitochondrial ROS upregulation and their contribution in the development of hypertension by overexpression of mitochondrial superoxide dismutase (SOD2) and mitochondria targeted SOD mimetic antioxidants. Our team continues to develop a deeper understanding of the complex redox cell signaling pathways and oxidative stress in the pathogenesis of hypertension and other pathological conditions.
As the FRIMCORE director and principal investigator my goal is to bring free radical study from the bench to the bedsides which include:
- Understand the specific roles of various sources of reactive oxygen species;
- Discover new therapeutic targets and design new site specific targeted antioxidants;
- Develop new tools for in vitro and in vivo ROS studies;
- Provide free radical training and mentorship both locally and nationally
Our research projects have been focused on three subjects:
- Role of mitochondrial oxidative stress in endothelial dysfunction and hypertension;
- Sources of superoxide (O2•) and hydrogen peroxide (H2O2) in vasculature and immune cells, their regulation and pathophysiological role.
- Development of new probes for measurements of superoxide (O2•), hydrogen peroxide (H2O2), nitric oxide (NO•) and peroxynitrite (ONOO−) in vitro and in vivo. Electron spin resonance studies of the free radical reactions and design of site-specific targeted antioxidants.
Our lab is interested in the study of reactive oxygen species in the endothelial function, regulation of immune response and cancer both in vitro and in vivo models. We start with the test tube free radical reactions mediated by O2• or lipid radicals, translate these reactions into complex cell culture research of ROS mediated regulation of mitochondrial and cellular functions, expand these cellular study to in vivo experiments on animals in order to determine the role of specific ROS dependent processes in the development of endothelial dysfunction, hypertension or cancer, and, finally, develop novel therapeutic strategies. If this is your first time here, please take a look at a more detailed description of our research projects and list of our publications. You may be also interested in seeing the people that work in the lab. Please do not hesitate to get in touch with us using contact information below.
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