Chris Tarr, Ph.D.

Drug Discovery Scientist I

    B.S.    Univeristy of Georgia, 2005


    Ph.D.  University of North Carolina at Chapel Hill, 2010

              Organic Chemistry

Phone: (615) 322-8662
Fax: (615) 322-8577
Email: james.c.tarr@vanderbilt.edu
Location: 12475 MRB IV (Langford)

Biosketch and Research Interests

Chris Tarr joined the Lindsley lab as a postdoctoral fellow in 2010. His research interests include synthetic organic chemistry, total synthesis, and drug discovery. His current projects include total synthesis of biologically interesting natural products and the library synthesis of small molecules for the identification of M1 receptor agonists.

Chris obtained his bachelor's degree in chemistry at the University of Georgia under the direction of Professor George Majetich where he worked on a second generation synthesis of salvadiol A. Also while at UGA, he interned at the EPA where he studied the degradation of organophosphorous pesticides during drinking water purification under the guidance of Dr. Timothy Collette. Upon graduation, Chris began his graduate career under the direction of Professor Jeffrey S. Johnson at the University of North Carolina. His graduate research focused on the development new methodologies for benzoin-type reactions using acyl silanes as masked acyl anions.

Selected Publications

Tarr, J. C.; Johnson, J. S. ‘Lanthanum Tricyanide-Catalyzed Acyl Silane-Ketone Benzoin Additions and Kinetic Resolution of Resultant α-Silyloxyketones’ J. Org. Chem. (2010), Vol. 75, 3317.

Tarr, J. C. and Johnson, J. S. ‘Lanthanum Tricyanide-Catalyzed Acyl Silane-Ketone Benzoin Additions’ Org. Lett. (2009), Vol. 11, 3870.

Garrett, M. R.; Tarr, J. C.; Johnson, J. S. ‘Enantioselective Metallophosphite-Catalyzed C-Acylation of Nitrones’ J. Am. Chem. Soc. (2007), Vol. 129(12), 944.

Duirk, Stephen E.; Tarr, J. Christopher; Collette, Timothy W. ‘Chlorpyrifos Transformation by Aqueous Chlorine in the Presence of Bromide and Natural Organic Matter’ J. Agric. Food Chemistry (2008), Vol. 56, 1328-1335.

Cherney, Daniel P.; Duirk, Stephen E.; Tarr, James C.; Collette, Timothy W. ‘Monitoring the Speciation of Aqueous Free Chlorine from pH 1 to 12 with Raman Spectroscopy to Determine the Identity of the Potent Low-pH Oxidant.’ Appl. Spectrosc. (2006), Vol. 60, 764-772.

Okun, Nelya M.; Tarr, James C.; Hillenshiem, Daniel A.; Zhang, Lei; Hardcastle, Kenneth I.; Hill, Craig L. ‘Highly Reactive Catalysts for Aerobic Thioether Oxidation. The Fe-substituted Polyoxometalate/Hydrogen Dinitrate System.’ J. Mol. Catal. A: Chemical (2006), Vol. 246, 11-17.

Chris Works

Curriculum Vita

Mailing Address:
Vanderbilt University Medical Center

Department of Pharmacology

1205 Light Hall
Nashville, TN 37232-0697