Leah Konkol, Ph.D.

Drug Discovery Scientist I

    B.S.    Univeristy of Wisconsin at Madison, 2007

              Chemistry, Biology

    Ph.D.  Northwestern University, 2013

              Organic Chemistry

Phone: (615) 322-7324
Fax: (615) 343-9332
Email: leah.c.konkol@vanderbilt.edu
Location: 12445 MRB IV (Langford)

Biosketch and Research Interests

Leah joined the Lindsley lab as a post-doctoral fellow in July of 2011. Her research interests include the design and synthesis of biologically active small molecules. Her current projects include the synthesis of mGluR5 allosteric modulators and the development of synthetic organic methodologies.

Leah received her Ph.D. from Northwestern University in May of 2012 under the direction of Professor Regan J. Thomson. Her doctoral research focused on developing new oxidative coupling methodologies. These methods allowed for the concise synthesis of 1,4-diketones which were also used to synthesize pyrroles, linked quinones, and enantiopure biaryls. Application of one of these methods allowed for the first enantioselective synthesis of bismurrayaquinone A, a biologically active axially chiral bis-carbazole alkaloid natural product isolated from M. koenigii (L.) Spreng (the curry-leaf tree).

Selected Publications

Konkol, L. C.; Guo, F.; Sarjeant, A. A.; Thomson, R. J. ‘Enantioselective Total Synthesis and Studies into the Configurational Stability of bismurrayaquinone A’ Angew. Chem. Int. Ed. (2011), Vol. 50, 9931-9934.

Guo, F.; Konkol, L. C.; Thomson, R. J. ‘Enantioselective Synthesis of Biphenols from 1,4-Diketones by Traceless Central-to-Axial Chirality Exchange&rsquo J. Am. Chem. Soc. (2011), Vol. 133, 18­­-20.

Konkol, L. C.; Jones, B. J.; Thomson, R. J. ‘Oxidative Carbon-Carbon Bond Formation via Allyldimethylsilyl Enol Ethers’ Org. Lett., (2009), Vol. 11, 5550-5553.

Avetta, C. T.; Konkol, L. C.; Taylor, C. N.; Dugan, K. C.; Stern, C. L.; Thomson, R. J. Diastereoselective Oxidative Carbon-Carbon Bond Formation via Silyl Bis-enol Ethers’ Org. Lett. (2008), Vol. 10, 5621-5624.

Leah Works

Curriculum Vita

Mailing Address:
Vanderbilt University Medical Center

Department of Pharmacology

1205 Light Hall
Nashville, TN 37232-0697