Patrick Gentry

Research Assistant I

      B.S. cum laude, Chemistry, Vanderbilt University, 2008
     

Phone: (615) 343-6627
Fax: (615) 343-8199
Email: patrick.r.gentry@vanderbilt.edu
Location: 12475 MRB IV (Langford)

Biosketch and Research Interests

Patrick Gentry earned his Bachelor’s Degree from Vanderbilt University, where he studied chemistry. In February of 2007, he joined the Lindsley lab as an undergraduate researcher and he has stayed on as a research tech in the wake of his graduation. His research interests are focused on medicinal chemistry and the synthesis of novel, receptor-specific molecules for the improved treatment of Alzheimer’s disease and Parkinson’s disease. His synthetic work has focused on positive allosteric modulators for mAChR4 and mGluR4 receptors as well as negative allosteric modulators for mGluR5 receptors. In the lab, Patrick is also known for his “Friday cookies” where he experiments with novel uses for butter, flour, sugar, and chocolate.

Selected Publications

Bridges, T.M.; Brady, A.E.; Kennedy, J.P.; Daniels, R.N.; Miller, N.R.; Kim, K.; Breininger, M.L.; Gentry, P.R.; Brogan, J.T.; Jones, C.K.; Conn, P.J.; Lindsley C.W. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg. Med. Chem. Lett. (2008 Sep. 10; Epub. ahead of print).

A.E. Brady, C.K. Jones, T.M. Bridges, J.P. Kennedy, A.D. Thompson, J.U. Heiman, M.L. Breininger, P.R. Gentry, H. Yin, S.B. Jadhav, J.K. Shirey, P.J. Conn, C.W. Lindsley.  “Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.”  Journal of Pharmacology and Experimental Therapeutics (2008 Sep. 4; Epub. ahead of print).