In The News

The Vanderbilt Specialized Chemistry Center

for Accelerated Probe Development

The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development was established as a member of the Molecular Libraries Probe Production Centers Network (MLPCN) initiated and supported by the National Institutes of Health (NIH) Molecular Libraries Roadmap.

The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development is housed within the newly constructed Medical Research Building IV (MRBIV), which also houses the Vanderbilt Program in Drug Discovery, and consists of three cores (Synthesis/Medicinal Chemistry, Cheminformatics and Administration).   The mission of the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development is to develop small molecule probes with exceptional potency and selectivity to explore molecular targets where no previous small molecule tools existed.Through this unique Roadmap mechanism (RO3), researchers can identify small molecule compounds to be used as probes for exploring the functions of genes and pathways in health and disease at the molecular, cellular and in vivo levels. Screening data generated by the MLPCN is deposited in a public database called PubChem which also provides cheminformatics data mining tools.

The director of the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development is Craig W. Lindsley, Associate Professor of Pharmacology and Chemistry.

Click here for more information about the center capabilities.

Please direct your general inquiries regarding probe development or project collaboration to Julie Le Engers.