Summer 2008 - What the Embryo Can Teach Us

Cells in the pancreas of a 1-week-old mouse that express the Ptf1a transcription factor gene are revealed in this photograph. The Ptf1a gene has been genetically engineered to express a bacterial enzyme that produces a dark blue color. In both mice and humans, Ptf1a is essential for formation of the entire pancreas, including insulin-secreting beta cells. By tracing the “cell lineage,” or family history, of Ptf1a-expressing cells, scientists hope to learn more about how to maintain—or restore—the function of beta cells. At top right is the sausage-shaped spleen (light orange), and at bottom is the duodenum.Islets of youth

Bill Snyder

In the not-too-distant future, cells taken from patients with diabetes will be “re-programmed” in the laboratory to create new insulin-producing beta cells that potentially can cure their disease. It sounds like science fiction, but researchers are quickly learning the genetic keys to this developmental path.  read more


The fine art of brain development

Melissa Marino, Ph.D.

It takes more than a hammer and chisel to shape the grandest sculpture of them all, the human brain. At least half the genome (10,000 genes or more) may be required. Equally surprising: development never stops. The living brain never achieves a “final” form.  read more


Joey Barnett, Ph.D., reveals an artificial valve in a preserved human heart.The lub-dub of a healthy heart

Leigh MacMillan, Ph.D.

Valves in action give the heart its characteristic lub-dub sound. When they fail, the results can be fatal. What if scientists could build replacement heart valves from patients’ own tissues? The hypothesis may be “outrageous,” but according to Vanderbilt researchers, it just might work.  read more


Trudi Schüpbach and Eric Wieschaus: A shared passion for nature’s truth

Princeton developmental biologists Eric Wieschaus and Trudi Schüpbach, who are husband and wife, have shared more than their work in the laboratory and a home life raising three daughters – they are of one mind when it comes to preserving the “purity” of scientific truth.  read article

The scientist in society

Internationally known reproductive biologist S.K. Dey advocates “a million scientists march” on Washington to sound the alarm about regulatory impediments and dwindling research support that are slowing the pace of progress. If the situation doesn’t improve, he warns, scientists may become “an endangered species.”  read article

Also in this Issue:

Nature’s operating system – an essay by Christopher V.E. Wright, D.Phil.

The power of animal models

Choosing sides

Gridlock keeps blood flowing, hearts in check

Riding the neural crest

The next generation