Gridlock keeps blood flowing, hearts in check pg. 2
The blood vessel blockage in zebrafish with a mutation in Gridlock resembles a human disorder called coarctation (constriction) of the aorta. Recent studies have also linked a Gridlock mutation to a human septal defect – a hole in the dividing wall of the heart.
Zhong is setting up international collaborations to search for Gridlock and other developmental gene mutations in patients with cardiovascular diseases.