Molecular fingerprints

The search for patterns of proteins in blood and tissue one day may help doctors diagnose diseases like cancer earlier and more accurately than ever before. These “molecular fingerprints” also may lead to new, more effective medicines and the ability to tailor treatments to individual patients. The ultimate aim: a more thorough understanding of disease and how to prevent it.  read article

Mining for proteins

Recent technological advances are helping scientists isolate and identify proteins, determine their three-dimensional structures, and figure out how they interact. The result is a much clearer picture of how the cellular “factory” operates, and how tiny changes in protein function can lead to disease.  read article

Leroy Hood: Discovery Science

Leroy Hood is known as the father of biotechnology for the development of groundbreaking biomedical instrumentation. Now he’s calling for a revolution of thought – an interdisciplinary, systems approach to biological discovery that challenges conventional wisdom about how research is conducted. A lifetime of influences, opportunities and challenges has led Hood to this, his meridian hour.  read article

EGFR – one protein’s story

We invited you to take a journey into a busy cell, to learn about proteins – how they’re made and what they do. We’ve selected as our guide the EGF receptor, a protein involved in signaling pathways that regulate cell growth.  read article

The future of proteomics

Two of the nation’s most prominent leaders in biotechnology, Tony White and Mike Hunkapiller, sit down with Lens for a wide-ranging interview on the challenges facing the field of proteomics, the growing need for collaboration between government, universities and private companies, and the potential impact that the debate over stem-cell research may have on scientific progress.  read article

Guest editorial by Lee Limbird

WINTER 2003—Capturing light. Providing focus. Altering perspective. That is the intent of our new publication, Lensread article

The power of proteins – a brief history

The term “protein” goes back to 1838, when Swedish chemist Jöns Berzelius coined it from the Greek proteios (primary) to emphasize the importance of this group of molecules as the primary building blocks of life.  read article

Editorial

Imagine yourself driving in the country in a convertible, watching the grassy fields roll by, feeling the wind in your face. Much of what you’re experiencing—including the ability to grasp the steering wheel and hear the music on the radio—is due to the actions and interactions of microscopic protein molecules in your nerves, your muscles, your eyes and ears.  read article

Challenges ahead

There are limits to the new science of proteins.

For example, researchers often don’t speak the same scientific “language,” making it difficult for them to share information or collaborate. To solve that problem, the international Human Proteome Organization is developing standards for the reporting of experimental data.  read article

Does proteomics need a “big government” approach?

The field of proteomics is burgeoning, thanks in large part to a generous flow of research funding – both public and private. But some observers wonder whether faster progress could be achieved with a concerted government effort – a “big science” program like the Human Genome Project (see “The Future of Proteomics”).  read article

Proteomics – a new language

The term “proteome” was coined by Australian researchers in the mid-1990s to describe all the PROTEins expressed by the genOME, the complete set of genetic material necessary for life. Proteomics, then, is the study of the expression, function and interaction of proteins in health and disease.  read article