Biomarkers

Protein adducts and other modified protein forms may reflect specific disease processes or drug and chemical toxicity. We are employing mass spectrometry-based approaches to discover and quantify protein adducts as biomarkers of type 2 diabetes and other diseases involving inflammation and systemic oxidative stress. We also are identifying cellular protein targets that can serve as biomarkers for the formation of reactive electrophiles involved in chemical toxicity and adverse drug reactions.