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Liebler Laboratory Proteomics Publications
Liebler Research Laboratory Links Research Focus: Protein Damage Lielber Research Laboratory Publications Liebler Research Laboratory Software Liebler Research Laboratory Personnel Graduate and Postdoctoral Training Opportunities in the Liebler Research Laboratory Liebler Research Laboratory Alumni Introduction to Proteomics by Daniel C. Liebler, Ph.D. Liebler Laboratory Contact Information Liebler Laboratory Home Page Mass Spectrometry Research Laboratory Home


Algorithms and software

Hansen, B. T., Davey, S.W., Ham, A.J.L. & Liebler, D.C. (2005) P-MOD: Algorithm and software to map modifications to peptide sequences using tandem MS data. J. Proteome Res. 4: 358-368.

Hansen, B.T., Mason, D.E., Jones, J.A. & Liebler, D.C. (2001) SALSA: An algorithm for detection of modified peptides by automated evaluation of their CID spectra in LC-tandem MS analyses, Anal. Chem. 73: 1676-1683.

Liebler, D.C., Hansen, B.T., Davey, S.W., Tiscareno, L. and Mason, D.E. (2002) Peptide sequence motif analysis of tandem MS data with the SALSA algorithm. Anal Chem. 74: 203-210.

Protein modification mapping with LC-MS-MS

Badghisi, H. and Liebler, D.C. (2002) Sequence mapping of epoxide adducts in human hemoglobin with LC-tandem MS and the SALSA algorithm. Chem. Res. Toxicol. 15: 799-805.

Lantum, H.B.M., Liebler, D.C., Board, P.G., Anders, M.W., (2002) Alkylation and inactiviation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone. Chem. Res. Toxicol. 15: 707-16.

Anderson, W.B., Liebler, D.C., Board, P.G. and Anders, M.W. (2002) Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta. Chem. Res. Toxicol. 15: 1387-1397.

Alderton, A.L., Faustman, C., Liebler, D.C. and Hill, D.W. (2003) Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal. Biochemistry 42: 4398-4405.

Person, M.D., Mason, D.E., Liebler, D.C., Monks, T.J., & Lau, S.S. (2004) Alkylation of cytochrome c by (Glutathion-S-yl)-1,4-benzoquinone and iodoacetamide demonstrates compound-dependent site specificity. Chem. Res. Toxicol. 18: 41-50.

Toxicoproteomics

Manza, L.L., Codreanu, S.G., Stamer, S.L., Smith, D.L., Wells, K.S., Roberts, R.L. and Liebler, Daniel C. (2004) Global shifts in protein sumoylation in response to electrophile and oxidative stress. Chem. Res. Toxicol. 17: 1706-1715.

Jones, J.A., Kaphalia, L., Moslen, M.T. and Liebler, D.C. (2003) Proteomic characterization of metabolism, protein adducts and hepatobiliary injury in rats exposed to 1,1-dichloroethylene and diclofenac. Chem. Res. Toxicol. 16: 1306-1317.

Peptide adduct tandem MS

Mason, D.E. & Liebler, D.C. (2000) Characterization of benzoquinone peptide adducts by electrospray mass spectrometry. Chem. Res. Toxicol. 13: 976-982.

Jones, J.A. & Liebler, D.C. (2000) Tandem MS analysis of model peptide adducts from reactive metabolites of the hepatotoxin 1,1-dichloroethylene, Chem. Res. Toxicol. 13: 1302-1312.

Methods

Manza, L.L., Stamer, S.L., Ham, A.L.L., Codreanu, S.G. and Liebler, D.C. (2004) Sample preparation and digestion for proteomic analyses using spin filters. Proteomics, in press.

Mason, D.E. and Liebler, D.C. (2003) Quantitative analysis of modified proteins by LC-MS-MS of peptides labeled with phenyl isocyanate. J. Proteome Res. 2: 265-272.

Reviews and Book Chapters

Liebler, D.C. (2002) Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures. Env. Health Persp. 110 (Suppl. 1): 3-9.

Liebler, D.C., Hansen, B.T., Jones, J.A., Badghisi, H. & Mason, D.E. (2003) Mapping protein modifications with liquid chromatography-mass spectrometry and the SALSA algorithm. In Proteome Characterization and Proteomics. Advances in Protein Chemistry, Vol. 65 (Smith,R.D. & Veenstra, T.D., eds.) Academic Press, San Diego, pp. 195-216.

Liebler, D.C. (2003) Analysis of protein modifications with LC-MS and the SALSA algorithm: New tools for toxicology. Exp. Lung Res. 29 (Suppl. 1): 88-92. Liebler, D.C., Hansen, B.T., Jones, J.A., Badghisi, H. & Mason, D.E. (2003) Mapping protein modifications with liquid chromatography-mass spectrometry and the SALSA algorithm. In Proteome Characterization and Proteomics. Advances in Protein Chemistry, Vol. 65 (Smith,R.D. & Veenstra, T.D., eds.) Academic Press, San Diego, pp. 195-216.

Liebler, D.C. (2004) Shotgun mass spec goes data-independent. Nat. Methods 1: 16-17.

Liebler, D.C. and Guengerich, F.P. (2005) Elucidating mechanisms of drug induced toxicity. Nat. Rev. Drug Discovery, in press.


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