Welcome to Crowelab


    RECENT NEWS
  • April 2005 - Hendrik Weitkamp, MD awarded Young Investigator Travel Award for 2005 SPR for his work on human rotavirus immunology.
  • Christopher Keefer, MD selected for 2005 Pediatric Infectious Diseases Fellowship Award and MedImmune fellowship award for work on RSV antibody structure/function
  • James Crowe, MD selected for 2005 Burroughs Wellcome Fund Clinical Scientist Award in Translational Research for work on human metapneumovirus cell biology and immunology
  • Cuixia Tian, MD presents work at American Association of Immunology, FASEB, April 2005, San Diego, CA. "Molecular and genetic characterization of rotavirus (RV)-specific human intestinal mucosal memory B cells -- highly mutated antibody genes but low levels of CD38 and isotype switching."

New publications from Crowelab in the last several months
  • Elizabeth L. Bentzen, Frances House, Thomas J. Utley, James E. Crowe, Jr., and David W. Wright. Progression of Respiratory Syncytial Virus Infection Monitored by Fluorescent Quantum Dot Probes. NanoLetters 5:591-5.
    Press review @ Nanotechweb.org
    Exploration articles @ Exploration Online Research Journal
  • Chen X, Rock MT, Hammonds J, Tartaglia J, Shintani A, Currier J, Slike B, Crowe JE Jr, Marovich M, Spearman P. Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses. J Virol. 2005 May;79(9):5537-47.
  • Rock MT, Yoder SM, Wright PF, Talbot TR, Edwards KM, Crowe JE Jr. Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization. J Immunol. 2005 Mar 15;174(6):3757-64.
  • Weitkamp JH, Kallewaard NL, Bowen AL, Lafleur BJ, Greenberg HB, Crowe JE Jr. VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7. J Immunol. 2005 Mar 15;174(6):3454-60.
  • Tai JH, Williams JV, Edwards KM, Wright PF, Crowe JE Jr, Dermody TS. Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. J Infect Dis. 2005 Apr 15;191(8):1221-4.
  • Shaklee JF, Talbot TR, Muldowney JA 3rd, Vaughan DE, Butler J, House F, Crowe JE Jr, Smith LH, Edwards KM. Smallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events. J Infect Dis. 2005 Mar 1;191(5):724-30.
  • Williams JV, Tollefson SJ, Heymann PW, Carper HT, Patrie J, Crowe JE. Human metapneumovirus infection in children hospitalized for wheezing. J Allergy Clin Immunol. 2005 Jun;115(6):1311-2.
  • Weitkamp JH, Lafleur BJ, Greenberg HB, Crowe JE Jr. Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. Hum Immunol. 2005 Jun;66(6):666-76.

  • Movie of rotavirus VP6 antibody binding courtesy of Michael Free. View it: [WMV (650 kb),AVI (4 mb)]


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