Jimmy Hao, M.B., Ph..D.
Department of Medicine, Division of Nephrology and Hypertension
renal medullary interstitila cell, prostanoids, hypertension, diabetic nephropathy
Our research interests include (1) the role of renal medullary interstitial cells in modulating renal function and systemic blood pressure. Renal medullary interstital cells, characterized by abundant lipid droplets in the cytosol, are special fibroblast-like cells residing in renal medulla between tubules and vessels (vasa recta). During the past several years, we have identified several molecules in these cells, such as COX2, GSK3ß, which have been shown to play important role in regulating cell death/survival following hypertonic stress, and modulating renal sodium excretion and medullary blood flow. We have also generated a transgenic renal medullary interstitial cell reporter mouse and a renal medullary interstitial cell specific Cre mouse, which will serve as great animal models for further exploring the role of these cells in blood pressure regulation, diabetic kidney damage and fibrotic reactions. (2) The role of prostanoids and their receptors in the physiology and pathophysiology of the kidney. Currently our interest is focused on the potential role of PGE2/EP4 and PGI2 in the pathogenesis of diabetic nephropathy. Conditional tissue specific deletion of these molecules is being developed using Cre-loxp technology.
Last updated on 2010-05-10
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