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Leslie S. Gewin, M.D.

Assistant Professor
Dept. of Medicine

Research keywords

Internal Medicine, Nephrology

Research description

The Gewin laboratory is interested in studying how growth factors modulate the kidney’s response to injury with a focus on the TGF-beta signaling pathway. TGF-beta is a pleiotropic growth factor that alters many cellular responses (e.g. matrix production, inflammation, apoptosis, proliferation), but the specific response depends upon the target cell type and microenvironment. We use mouse models with the TGF-beta type II receptor deleted in a conditional and inducible manner to investigate how TGF-beta signaling affects the response to injury in a cell-specific fashion. We have a particular interest in how TGF-beta signaling affects the response of proximal tubule epithelium, a key target in human disease, to both acute and chronic injuries. We have generated proximal tubules in vitro which we use to better understand how TGF-beta affects epithelial cell function and the response of cells to other growth factors relevant to injury and repair. Fibroblasts are thought to be the primary cell type responsible for the matrix production comprising fibrosis, the common pathway to end-stage renal disease. We are also investigating fibroblasts’ role in tubulointerstitial fibrosis, how their function is altered by growth factors like TGF-beta, and how to better characterize this population of interstitial cells.

Last updated on 2013-10-29

Zhang, M.

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