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In Vivo Imaging to Assess Single Kidney Function

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There is considerable interest and potential value in the development of in vivo imaging methods that can non-invasively assess renal function. The overall goal of the Vanderbilt Mouse Kidney Imaging Core is to develop, implement, optimize, validate, and apply quantitative non-invasive in vivo imaging methods for the assessment of renal function and injury in vivo. The Imaging Core will be dedicated to providing scientific, technical, and educational resources for non-invasive imaging of mouse models of kidney disease in vivo and support for each pilot project. The Imaging Core will employ conventional as well as novel imaging methods across a wide range of modalities including MRI, PET, SPECT, ultrasound and optical. The imaging efforts will complement the physiological information obtained from conventional assays of kidney function and facilitate the understanding of pathological mechanisms of kidney disease.

In addition to providing the methods required by VKDC projects, the Imaging Core will develop techniques that can augment these studies as well as support developmental pilot projects. The equipment and personnel needed to support research by investigators within the VKDC will be provided by the Center for Small Animal Imaging (CSAI) at Vanderbilt University Institute of Imaging Science (VUIIS). Funds obtained through the MKPDC will support collaborations with expert imaging science faculty for the development and implementation of cutting edge imaging protocols; support for imaging system operators and technical staff who will handle animal preparation and monitoring as well as operate the instruments; support for data analysis and for quantitative image analysis customized to specific applications, including the co-registration and integration of multiple imaging modalities, histology and proteomics. Thus, the overall aims of the imaging core are:

  • Provide non-invasive imaging metrics of kidney physiology and treatment response to investigators in the Vanderbilt VKDC.
  • Provide collaborations with expert imaging science faculty for the implementation of cutting edge imaging protocols to address each investigators goals. The Imaging Core will support experts in nuclear, optical, MRI, CT, and ultrasound imaging.
  • Provide support for data analysis and for quantitative image analysis customized to specific applications, including the co-registration and integration of multiple imaging modalities.

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Last updated on 2013-11-06 Moderated by: Takamune Takahashi

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