Glomerular filtration > Background Section
Glomerular filtration rate (GFR) is a key indicator of renal function (10). Abnormalities in GFR occur in many primary renal diseases, as well as being a secondary result of systemic diseases including diabetes mellitus. In the early stages of diabetic nephropathy in most species including man GFR increases (i.e. hyperfiltration) (11). This early increase is a harbinger of proteinuria and subsequent renal failure that characterize diabetic nephropathy. Thus, evaluation of GFR is a mainstay for evaluating renal function and monitoring the progression of kidney disease.
In our center, the following methods are offered to assess glomerular filtration function: serum creatinine (Scr), creatinine clearance and inulin clearance.
Publications for Glomerular filtration (1)
Meneton P, Ichikawa I, Inagami T, Schnermann J. Renal physiology of the mouse. Am J Physiol Renal Physiol (2000) 278:F339-51
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As the transgenic and gene-targeting technology has become an invaluable
experimental approach to study the function of gene products, the need has
been expanded to assess the physiology in the mouse, which is virtually
the only animal species to which that new genetic technology can apply. In
this regard, renal physiologists have also received fruits of success from
modern technology in several key areas, and areas are expanding in both
depth and scope.
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