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Renal specific transgenic database

This database is intended to assist all investigators interested in renal-specific transgene expression, focusing specifically of transgenic lines expressing Cre, reporter mice and "Tetmice" (expressing tetracycline-regulated transactivators). It will be updated as soon as new information becomes available, thereby providing the most timely information on gene targeting in the kidney. The database is also intended to contain valuable information that is not easily found otherwise, including all sites of transgene expression as well as the amount of transgene expression (degree of variegation) within the targeted cell type(s). This information, combined with existing databases on floxed alleles, including the Nagy Lab website and the Jackson Labs website, will allow renal investigators to easily understand what transgenic tools are available and how they might be utilized.




Cre Strains

Common NameRenal Cell TypesCategoryContributor
11-hydroxysteroid dehydrogenase-2-CreConnecting Tubule,Principal cells (collecting duct)creAniko Naray-Fejes-Toth
Aquaporin 2-CrePrincipal cells (collecting duct)creDonald Kohan
Aquaporin 2-CrePrincipal cells (collecting duct)creEdith Hummler
Gamma glutamyl transpeptidase (GGT)-CreProximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Proximal tubulecreEric Neilson
HoxB7-CrePrincipal cells (collecting duct),Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct),Ureteric bud,Ureteric bud tip,Ureteric bud stalkcreAndrew McMahon
Ksp-cadherin-CreConnecting Tubule,Principal cells (collecting duct),Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct),Thick Limb (Loop of Henle),Distal convoluted tubule,Condensing metanephric mesenchyme (early after UB bud),Ureteric budcrePeter Igarashi
Nephrin-CreGlomerular podocytescreSusan Quaggin
Odd-skipped related-2-CreCondensing metanephric mesenchyme (early after UB bud)creYu Lan
Pax8-CreCondensing metanephric mesenchyme (early after UB bud),Ureteric budcreMeinrad Busslinger
Phosphoenolpyruvate carboxykinase (PEPCK)-CreProximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Proximal tubulecreVolker Haase
Podocin-CreGlomerular podocytescreLarry Holzman
Renin-CrecreJurgen Schnermann
Sodium-glucose cotransporter-2-CreProximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Proximal tubulecreMichel Tauc
Tamm Horsfall Protein-CreThick Limb (Loop of Henle)creDonald Kohan
V-ATPase B1-CreConnecting Tubule,Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct)creRaoul Nelson

Cre/ERT Strains

Common NameRenal Cell TypesCategoryContributor
Cited1 CreERT2Cap mesenchymeCre/ERTMark de Caestecker
Gamma glutamyl transpeptidase (GGT)-CreERT2Proximal tubule S3 segment,Proximal tubuleCre/ERTPetra Pennekamp
Ksp-cadherin-CreERT2Connecting Tubule,Principal cells (collecting duct),Proximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Thick Limb (Loop of Henle),Distal convoluted tubule,Proximal tubuleCre/ERTDorien J. M. Peters
Podocin-CreERT2Glomerular podocytesCre/ERTFarhad Danesh

Reporter Strains

Common NameRenal Cell TypesCategoryContributor

Tet Strains

Common NameRenal Cell TypesCategoryContributor
Pax8-rtTAConnecting Tubule,Principal cells (collecting duct),Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct),Proximal tubule S1 segment,Proximal tubule S2 segment,Proximal tubule S3 segment,Thin limb Ascending (Loop of Henle),Thin limb Descending (Loop of Henle),Thick Limb (Loop of Henle),Macula Densa (Thick Ascending Limb),Distal convoluted tubule,Proximal tubuletetRobert Koesters
Podocin-rtTA (Holthofer)Glomerular podocytestetHarry Holthofer
Podocin-rtTA (Kopp)Glomerular podocytestetJeffrey Kopp

Other Strains

Common NameRenal Cell TypesCategoryContributor