Microbiology and Immunology Seminar Series, Tuesday, March 1, 3 p.m.
The Department of Microbiology and Immunology and Digestive Disease Research Center Seminar
Karen Guillemin, Ph.D.
Associate Professor of Biology
Institute of Molecular Biology
University of Oregon
“Bacterial regulation of epithelial cell proliferation in the zebrafish intestine”
Rates of cell proliferation in the intestinal epithelium are regulated by host genetic programs and modulated by both beneficial and pathogenic bacteria. Using the model vertebrate, zebrafish, we have shown that resident bacteria can influence the rates of intestinal epithelial cell proliferation in part by regulating the Wnt signaling pathway.
We have also explored how the CagA bacterial effector protein from the gastric pathogen, Helicobacter pylori, influences cell proliferation and Wnt signaling in the zebrafish intestine. Our results suggest that both bacterial associations and host genotype interact to influence rates of intestinal cell proliferation in health and disease.
Tuesday, March 1
Room 1220 MRB III
Host: Timothy Cover, M.D.
Sponsored by: Cellular and Molecular Microbiology Training Grant
and Digestive Disease Research Center