Microbiology & Immunology Departmental Seminar Series Tuesday, March 22, 3 p.m.
Nan-ping Weng, M.D., Ph.D.
Chief, Lymphocyte Differentiation Section
Laboratory of Molecular Biology and Immunology
National Institute on Aging, NIH
"Assessing the epigenetic basis of memory T cell response and the size of TCR repertoire by high-throughput sequencing"
Immunological memory and antigen-specific recognition are two defining features of the adaptive immunity. We are interested in the epigenetic mechanism that controls CD8 memory T cell response to antigen, and the size the antigen receptor diversity of T cells in human and its change with aging.
Using the high-throughtput sequencing method, we are able to assess 1) the genome-wide epigenetic changes and their consequence in differential gene expression in memory T cells, and 2) the size of T cell antigen receptor and its age-associated changes.
Tuesday, March 22,
Room 1220 MRB III
Host: Mark Boothby, M.D., Ph.D.