The Department of Microbiology and Immunology Seminar Series, Tuesday, March 29, 3 p.m.
Timothy Blackwell, M.D.
Professor of Medicine, Cell and Developmental Biology, and Cancer Biology
"Promotion of lung cancer by NF-κB pathway signaling"
In smokers, the primary risk factors for developing lung cancer are age and the presence of chronic obstructive pulmonary disease (COPD).
Although inflammation appears to be involved in the pathogenesis of both lung cancer and COPD, we have only recently begun to elucidate specific mechanisms tying COPD and lung cancer together through immune cells and pathways.
Our data support the concept that chronic Nuclear Factor-κB (NF-κB) pathway activation mediates persistent airway inflammation in COPD and increases lung cancer risk. In transgenic mice engineered to inducibly activate NF-κB only in airway epithelium, chronic NF-κB signaling drives a COPD-like pattern of chronic airway inflammation, resulting in significant emphysema. We have used this model to identify specific roles for individual inflammatory cell types during different stages of inflammation-associated tumorigenesis.
Tuesday, March 29
Room 1220 MRB III
Host: Andrew Link, Ph.D.