September 15, 2011

Federal Limited Submission Funding Opportunities Guidelines and Announcement

 General guidelines

All applicants for federal limited submission funding opportunities should notify the Office of Research of their intention to apply. An internal proposal should be submitted; if necessary a faculty review committee will select the institutional applicant(s). Unless otherwise specified, internal proposals should include the following:

• Faculty PI/PD(s)
• Tentative title of the intended proposal
• Names of other key faculty, departments expected to participate
• A brief (one page maximum) summary of the scope and content of the program.

Additional information may be requested.

Questions? Contact Susan Meyn in the Office of Research for more information, or to submit an internal proposal, at s.meyn@vanderbilt.edu or 322-0470.

 Recent Funding Opportunity Announcements

NIGMS Center for HIV/AIDS-Related Structural Biology (P50)
RFA-GM-12-003: http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-12-003.html

Vanderbilt is limited to a single application to this program.

Internal Proposal Deadline: Dec. 27
Application Due Date: Jan. 6, 2012

The National Institute of General Medical Sciences invites applications for Centers that will support the determination of the structures of macromolecular complexes among and between components of the human immunodeficiency virus (HIV) and the components of host cells.

As for any virus, the life-cycle of HIV is comprised of a progression of assembly and disassembly of multiple macromolecular complexes among components of both the virus and the host cell. From the interplay of viral proteins among themselves and with the cellular machinery, to the activity of viral enzymes and the usurpation of host factors to achieve infection, such complexes are the fundamental effectors of viral reproduction and proliferation.

These complexes range from binary protein-protein and protein-nucleic acid complexes to much larger multicomponent complexes. A number of these interactions are documented in the HIV-1, Human Protein Interaction Database. These complexes offer the potential to provide intervention strategies for the treatment and prevention of AIDS.

Although the first step towards the exploitation of these targets, the determination of their high resolution structures, has been accomplished in several cases, much more remains to be done, including the identification and characterization of additional host factors. Thus the goal of this Funding Opportunity Announcement (FOA) is the continuation and/or creation of centers dedicated to the determination of the high-resolution structures of these complexes.

In order to succeed, these centers must collaborate among themselves and must reach out to the biological community doing research aimed at identifying and validating the presence of these complexes, including sharing of data by timely submission of structural information to appropriate databases.