December 7, 2010

The Departments of Microbiology and Immunology Research In Progress Seminar Thursday, Dec. 9, 9:30 a.m.

 The Departments Of
Microbiology and Immunology
 

Research In Progress Seminar

Christopher Cummings, Graduate Student, Biochemistry
From the Laboratory of Billy Hudson, Ph.D.

”Building Basement Membranes: Detailing the Synthesis of Sulfilimine Bonds in Collagen IV Networks”

Basement membranes are present throughout the body, being repeatedly traversed during physiologic and disease circumstances such as regular immune surveillance and cancer metastasis.

These membranes provide dual structural and molecular signaling cues for nearby cells, and collagen IV molecules are critical components of proper membrane function. Within the extracellular environment, collagen IV molecules are assembled into networks that are structurally reinforced by novel sulfilimine bonds extending between lysine and methionine residues of adjoining collagen IV molecules.

Current evidence strongly indicates that the mechanism of bond formation is enzymatically catalyzed, and provides insight into the details of this process.
 

Thursday, Dec. 9
9:30 a.m.
MCN, Room A5305