RESEARCH SUMMARY
The area of intensive
care medicine offers tremendous opportunity for patient-oriented research.
The opportunity to derive important clinical data non-invasively, or minimally
invasively, in a way that is safe, reliable, affordable, and reproducible,
and that will impact patient care ‘on the spot’ is a pivotal part
of my research and educational interests.
In particular, I am interested in
developing ultrasound as a tool in the intensive care unit, operating room,
and emergency room. Ultrasound is aptly suited for hemodynamic monitoring,
procedure guidance, and organ perfusion determination. Muscle weakness is
a common and important complication of critical illness. Ultrasound can be
used to assess muscle and nerve characteristics, and their evolution during
and after critical illness. In addition, ultrasound is the most compact health
diagnostic modality for use during space travel, which is an application I
look forward to optimizing.
Research on endovascular ultrasound neuromonitoring of intracranial anatomy
and hemodynamics at the bedside is one of the areas in which I am most active
at the moment. The opportunity to assess at the bedside, the development of
cerebral mass effect — as in stroke, brain trauma, etc. — and
its effects on the local and global cerebral perfusion allows for earlier
diagnosis and therapeutic intervention that may improve neurological outcome
for a patient. Another of my research interests is sono-delivery of drugs.
It may be possible to deliver drugs packed in microbubbles — into a
tumor, for example — that can then be burst with ultrasound to release
their contents, thereby decreasing systemic toxicity. Such localized delivery
would open the field to a new branch of medicine: neurotherapeutics.
SELECTED PUBLICATIONS
Pubmed Link
Jarquin-Valdivia AA, Buchhalter.
Delayed diagnosis of pediatric Langerhans’ cell histiocytosis: case
report and retrospective review of pediatric cases at Mayo Clinic. J. Child
Neurol 16(7): 535-8, Jul 2001.
Jarquin-Valdivia AA, Wijdicks
EF, McGregor C. Neurologic complications following heart transplantation in
the modern era: decreased incidence, but postoperative stroke remains prevalent.
Transplantation Proceedings 31(5): 2161-2, Aug 1999.
Book chapters:
Jarquin-Valdivia AA, Bonovich
D, Hemphill JC. The Role of the Neurointensivist in the Management of Traumatic
Brain Injury. Contemporary Neurosurgery (ed.Paul Matz). 4(2): 131-8, 2003.
Jarquin-Valdivia AA, Bonovich
D. Brain Death. In Critical Care Secrets, 3rd edition (ed. PE Parsons and
J Weiner-Kronish), pp. 330-34, 2003.
Jarquin-Valdivia AA, Bonovich
D. Coma. In Critical Care Secrets, 3rd edition (ed. PE Parsons and J Weiner-Kronish),
pp. 327-329, 2003.
CONTACT INFORMATION
Adrian A. Jarquin-Valdivia, M.D., R.D.M.S.
Assistant Professor of
Neurology Anesthesiology and Internal Medicine Neurocritical Care, Neurosonology
Director Neurology Clerkship
Master Clinical Teacher
Vanderbilt Stroke Center
A-0118 Medical Center North
Nashville, TN 37232-2551
Phone: 615-936-0060
Fax: 615-936-1286
Education: 615-936-1567
