| Patient Care Specialty |
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PET Radiopharmaceutical / Blood metabolite studies etc. |
| Research
Specialty |
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Preparation of PET radiopharmaceuticals.
Characterization of PET/ SPECT ligands for modeling of imaging studies
Autoradiography of postmortem brain of human, monkey and rats. |
| Research
Description |
Neuroscience/ Radiochemistry.
Preparation of high specific activity radioligands such as [18F] Fallypride, [18F] DT2B (Avid 133), [18F] FLT, [18F] FMIZO, [18F] Setoperone, [18F] FECENT, [18F] FPEB, [11C] Acetate, etc. for PET imaging of human, animal, and in vivo and in vitro studies.
Characterization of PET ligands for brain receptor studies.
Optimization of preparative HPLC for isolation and separation of PET radioisotopes.
Application and modification of novel techniques for radio ligand synthesis module. Along with hybridization of conventional and microwave synthesis. |
| Publications
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Riccardi, P, Baldwin, R, Salomon, R, Anderson, S, Ansari, MS, Li, R, Dawant, B, Bauernfeind, A, Schmidt, D, Kessler, R. Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride. Biol Psychiatry, 63(2), 241-4, 2008 Kessler, RM, Ansari, MS, Riccardi, P, Li, R, Jayathilake, K, Dawant, B, Meltzer, HY. Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine. Neuropsychopharmacology, 31(9), 1991-2001, 2006 Riccardi, P, Li, R, Ansari, MS, Zald, D, Park, S, Dawant, B, Anderson, S, Doop, M, Woodward, N, Schoenberg, E, Schmidt, D, Baldwin, R, Kessler, R. Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans. Neuropsychopharmacology, 31(5), 1016-26, 2006 Riccardi, P, Zald, D, Li, R, Park, S, Ansari, MS, Dawant, B, Anderson, S, Woodward, N, Schmidt, D, Baldwin, R, Kessler, R. Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study. Am J Psychiatry, 163(9), 1639-41, 2006 Kessler, RM, Ansari, MS, Riccardi, P, Li, R, Jayathilake, K, Dawant, B, Meltzer, HY. Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol. Neuropsychopharmacology, 30(12), 2283-9, 2005 Rieck, Richard W, Ansari, M S, Whetsell, William O, Deutch, Ariel Y, Kessler, Robert M. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology, 29(2), 362-72, 2004 Hewlett, W A, Trevedi, B L, Zhang, Z J, de Paulis, T, Schmidt, D E, Lovinger, D M, Ansari, M S, Ebert, M J. Characterization of (S)-des-4-amino-3-[125I]iodozacopride ([125I]DAIZAC), a selective high-affinity radioligand for 5-hydroxytryptamine3 receptors. J Pharmacol Exp Ther, 288(1), 221-31, 1999 Kessler RM, Whetsell WO, Ansari MS, Taminga CA, Mason NS. [125I] epidepride binding in post mortem human brain. Schizophr Res, 15(1-2), 62, 1995 Votaw, J R, Ansari, M S, Mason, N S, Schmidt, D, de Paulis, T, Holburn, G, Clanton, J A, Votaw, D B, Manning, R G, Kessler, R M. Dosimetry of iodine-123-epidepride: a dopamine D2 receptor ligand. J Nucl Med, 36(7), 1316-21, 1995 Kessler, R M, Votaw, J R, Schmidt, D E, Ansari, M S, Holdeman, K P, de Paulis, T, Clanton, J A, Pfeffer, R, Manning, R G, Ebert, M H. High affinity dopamine D2 receptor radioligands. 3. [123I] and [125I]epidepride: in vivo studies in rhesus monkey brain and comparison with in vitro pharmacokinetics in rat brain. Life Sci, 53(3), 241-50, 1993 Kessler, R M, Votaw, J R, de Paulis, T, Bingham, D R, Ansari, M S, Mason, N S, Holburn, G, Schmidt, D E, Votaw, D B, Manning, R G. Evaluation of 5-[18F]fluoropropylepidepride as a potential PET radioligand for imaging dopamine D2 receptors. Synapse, 15(3), 169-76, 1993 Kessler, R M, Whetsell, W O, Ansari, M S, Votaw, J R, de Paulis, T, Clanton, J A, Schmidt, D E, Mason, N S, Manning, R G. Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride. Brain Res, 609(1-2), 237-43, 1993 Hoff, S J, Stewart, J R, Frist, W H, Kessler, R M, Sandler, M P, Atkinson, J B, Votaw, J, Carey, J A, Ansari, M S, Merrill, W H. Noninvasive detection of heart transplant rejection with positron emission scintigraphy. Ann Thorac Surg, 53(4), 572-7, 1992 Kessler, R M, Mason, N S, Votaw, J R, De Paulis, T, Clanton, J A, Ansari, M S, Schmidt, D E, Manning, R G, Bell, R L. Visualization of extrastriatal dopamine D2 receptors in the human brain. Eur J Pharmacol, 223(1), 105-7, 1992 Clanton JA, de Paulis T, Schmidt DE, Ansari MS, Manning RG, Baldwin RM, Kessler RM. Radiolabelling of (S)-N-[(1-ethyl-2-pyrrolidinyl)]-5-iodo-2,3-dimethoxylbenzamide, preparation of [123I] and [125I]epidepride. J Label. Comp. Radiopharm, 29, 745-751, 1991 Kessler, R M, Ansari, M S, Schmidt, D E, de Paulis, T, Clanton, J A, Innis, R, al-Tikriti, M, Manning, R G, Gillespie, D. High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors. Life Sci, 49(8), 617-28, 1991 Kessler, R M, Ansari, M S, de Paulis, T, Schmidt, D E, Clanton, J A, Smith, H E, Manning, R G, Gillespie, D, Ebert, M H. High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides. J Nucl Med, 32(8), 1593-600, 1991 |
| Postdoctoral
Position Available |
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N/A |
| Postdoctoral
Position Details |
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N/A |
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