Bruce M. Damon, Ph.D.

Position: Assistant Professor

Department: Radiology and Radiological Sciences

Lab Url: N/A

Email: bruce.damon@vanderbilt.edu

Office Address: 1161 21st Avenue South
Office Address2: MCN AA-1105
Nashville , TN 37232-2310
Phone :(615) 322-8355
Fax: 615-322-3764

Lab Address: AA-3105 Medical Center North/VUIIS


Bruce M. Damon's picture
  Bruce M. Damon, Ph.D.
Patient Care Specialty
NMR imaging, NMR spectroscopy, NMR relaxometry, Muscle structure-function relationships, Diffusion-tensor MRI muscle fiber tracking, NIR spectroscopy and tomography, electromyography, muscle fatigue,NMR,Spectroscopy

Research Specialty
Development and application of novel imaging and spectroscopic approaches to studying muscle function.

Research Description
Proper neuromuscular function requires the coordination of multiple body systems, including those for motor command and coordination, energy delivery and utilization, and the generation and expression of force and other mechanical variables. We are using various imaging and spectroscopic approaches to study this integration, in both human and animal studies. These approaches include structural and physiological magnetic resonance imaging (MRI), biochemical studies using magnetic resonance spectroscopy (MRS), tissue oxygenation and blood flow measurements using near-infrared spectroscopy (NIRS), and assessments of motor unit activation using electromyography (EMG). Specific projects include:

Non-invasive Assessment of Muscle Microvascular Function: We have developed an MRI method for assessing changes in blood volume and oxygenation following brief isometric contractions in vivo. We are applying this technique to the study of microvascular dysfunction in persons with Type 2 Diabetes Mellitus.

Biophysical Basis of Muscle Functional MRI: Exercising muscles appear with increased signal intensity in certain types of MR images. These signal intensity changes result indirectly from the metabolic and hemodynamic responses of muscles to exercise. This approach has become known as muscle functional MRI (mfMRI). The objective of this project is to develop a comprehensive and quantitative description of the biophysical and physiological basis of mfMRI, in order to accelerate its application in physiological studies.

Structure-Function Relationships in Skeletal Muscle: The objective of this project is to develop and apply methods for non-invasive study of the relationship between skeletal muscle fibers? architectural properties and mechanical behavior during isometric contraction. In this project, we are combining diffusion-tensor MRI muscle fiber tracking methods, strain imaging, and mfMRI methods.

Publications
Heemskerk, AM, Sinha, TK, Wilson, KJ, Ding, Z, Damon, BM. Quantitative assessment of DTI-based muscle fiber tracking and optimal tracking parameters. Magn Reson Med, 61(2), 467-72, 2009

Kan, JH, Heemskerk, AM, Ding, Z, Gregory, A, Mencio, G, Spindler, K, Damon, BM. DTI-based muscle fiber tracking of the quadriceps mechanism in lateral patellar dislocation. J Magn Reson Imaging, 29(3), 663-70, 2009

Louie, EA, Gochberg, DF, Does, MD, Damon, BM. Transverse relaxation and magnetization transfer in skeletal muscle: effect of pH. Magn Reson Med, 61(3), 560-9, 2009

Sanchez OA, Louie EA, Copenhaver EA, Damon BM. Repeatability of a dual gradient-recalled echo MRI method for monitoring post-isometric contraction blood volume and oxygenation changes. NMR in Biomedicine, in press, , 2009

Damon, BM. Effects of image noise in muscle diffusion tensor (DT)-MRI assessed using numerical simulations. Magn Reson Med, 60(4), 934-44, 2008

Damon, BM, Wadington, MC, Lansdown, DA, Hornberger, JL. Spatial heterogeneity in the muscle functional MRI signal intensity time course: effect of exercise intensity. Magn Reson Imaging, 26, 1114-1121, 2008

Kan, JH, Hernanz-Schulman, M, Damon, BM, Yu, C, Connolly, SA. MRI features of three paediatric intra-articular synovial lesions: a comparative study. Clin Radiol, 63(7), 805-12, 2008

Lee DJ, Mencio GA, Hernanz-Schulman M, Nealy BJ, Damon BM, Kan JH. Comparison of acute and subacute treatment of buckle fractures in the pediatric population. Journal of Family Practice, in press, , 2008

Damon, BM, Hornberger, JL, Wadington, MC, Lansdown, DA, Kent-Braun, JA. Dual gradient-echo MRI of post-contraction changes in skeletal muscle blood volume and oxygenation. Magn Reson Med, 57(4), 670-9, 2007

Damon, BM, Louie, EA, Sanchez, OA. Physiological basis of muscle functional MRI. J Gravit Physiol, 14(1), P85-8, 2007

Damon, BM, Wadington, MC, Hornberger, JL, Lansdown, DA. Absolute and relative contributions of BOLD effects to the muscle functional MRI signal intensity time course: effect of exercise intensity. Magn Reson Med, 58(2), 335-45, 2007

Heemskerk AM and Damon BM. Diffusion Tensor MRI Assessment of Skeletal Muscle Architecture. Current Medical Imaging Reviews, 3( ), 152-160, 2007

Lansdown, DA, Ding, Z, Wadington, M, Hornberger, JL, Damon, BM. Quantitative Diffusion Tensor MRI-Based Fiber Tracking of Human Skeletal Muscle. J Appl Physiol, 103, 673-681, 2007

Maguire, MA, Weaver, TW, Damon, BM. Delayed Blood Reoxygenation following Maximum Voluntary Contraction. Med Sci Sports Exerc, 39(2), 257-67, 2007

Damon, BM, Gore, JC. Physiological basis of muscle functional MRI: predictions using a computer model. J Appl Physiol, 98(1), 264-73, 2005

Damon BM, Gore JC. Biophysical basis of magnetic resonance imaging of small animals. Methods in Enzymology, 385(), 19-40, 2004

Damon, BM, Gore, JC. Biophysical basis of magnetic resonance imaging of small animals. Methods Enzymol, 385, 19-40, 2004

Wigmore DM, Damon BM, Pober DM, Kent-Braun JA.. MRI Measures of Perfusion-Related Changes in Human Skeletal Muscle During Progressive Contractions. Journal of Applied Physiology, 97(), 2385-2394, 2004

Damon, BM, Hsu, AC, Stark, HJ, Dawson, MJ. The carnosine C-2 proton''s chemical shift reports intracellular pH in oxidative and glycolytic muscle fibers. Magn Reson Med, 49(2), 233-40, 2003

Damon, BM, Wigmore, DM, Ding, Z, Gore, JC, Kent-Braun, JA. Cluster analysis of muscle functional MRI data. J Appl Physiol, 95(3), 1287-96, 2003

Price TB, Kamen G, Damon BM, Knight CA, Applegate B, Gore JC, Eward K, Signorile JF. Comparison of MRI and EMG to study muscle activation by dynamic plantar flexion. Magnetic Resonance Imaging, 21(8), 853-861, 2003

Sacristan E, Baheza RA, Rodriguez AO, Does MD, Damon BM, Gore JC. Dual frequency coil and MRIS method for the characterization of ischemic injury in the intestinal wall. Annual International Conference of the IEEE Engineering in Medicine and Biology ? Proceedings, 1, 474-477, 2003

Damon BM, Ding Z, Anderson AW, Freyer AS, Gore JC. Validation of diffusion tensor MRI-based muscle fiber tracking. Magnetic Resonance in Medicine, 48, 97-104, 2002

Damon BM, Gregory CD, Hall KL, Stark HJ, Gulani V, Dawson MJ. Intracellular acidification and volume increases explain 1H R2 decreases during exercise. Magnetic Resonance in Medicine, 47, 14-23, 2002

Ivy JL, Goforth HW, Damon BM, McCauley TR, Parsons EC, Price TB. Early post-exercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement. Journal of Applied Physiology, 93, 1337-1344, 2002

Bruce BC, Carragher BO, Damon BM, Dawson MJ, Eurell JA, Gregory CD, Lauterbur PC, Marjanovic MM, Mason-Fossum B, Morris HD, Potter CS, Thakkar U. Chickscope: an interactive MRI classroom curriculum innovation for K-12. Computers and Education Special Issue on Multimedia, 29, 73-87, 1997

Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
03/23/2009

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